Download - Vesicular transport
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VESICULAR
TRANSPORT
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INTRODUCTION
bubble-like membranous structure that stores and transports cellular products, and digests metabolic wastes within the cell;
an intracellular membranous sac that is separated from the cytosol by at least one lipid bilayer.
Secretory Vesicles
Transport Vesicles
Storage Vesicles
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INTRODUCTION Transport across but not through the
membrane
Mode of transport of macromolecules
Requires metabolic energy but is independent of concentration gradient
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CATEGORIES ENDOCYTOSIS
EXOCYTOSIS
TRANSCYTOSIS
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ENDOCYTOSIS TYPES Phagocytosis- cell eating
Pinocytosis- cell drinking Receptor-mediated
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ENDOCYTOSIS
Mechanisms : Constitutive Pathway
Clathrin-mediated Pathway internalization of many receptors
and the ligands bound to them—including, for example, nerve growth factor and low-density lipoproteins
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Clathrin-mediated endocytosis
Clathrin coated vesicles – COP I & COP II
Clathrin
Adaptor Proteins
Dynamin Pinchase
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Clathrin-mediated endocytosis
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EXOCYTOSIS Non-Constitutive / Regulated
Pathway
Constitutive Pathway
Exocytosis-Endocytosis coupling maintains the surface area of the cell at its normal size.
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INTRA CELLULAR VESICULAR TRAFFIC
Biosynthetic- Secretory pathway
Endocytotic pathway
Retrieval pathways
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Vesicular traffic occurs in an orderly fashion
Selective & Specific
Rab proteins
SNARE proteins
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Rab Proteins
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SNARE Proteins – mediate vescile fusion
V-SNAREs – Docking proteins T-SNAREs – Latch proteins
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APPLIED ASPECTSBotulism & Tetanus
AUTOPHAGY or AUTOPHAGOCYTOSIS
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APPLIED ASPECTS
FAMILIAL HYPERCHOLESTEROLEMIA
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THANK YOU
A colorized scanning electron microscope picture of a nerve ending that has been broken open to reveal the synaptic vesicles (orange and blue) beneath the cell membrane.