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영 남 대 학 교YE
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Medical Materials Medical Materials for the Next Millenniumfor the Next Millennium
Sukyoung KimSukyoung Kim
Yeungnam UniversityYeungnam University
Metallurgy & Materials EngineeringMetallurgy & Materials Engineering
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What Happen During the 21th Century ?
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Death
OldOld
IllnessIllness
InjuryInjury
LifeLife
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영 남 대 학 교YE
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The Aged = Needs of Biomaterials
15.9
69.4
14.5
14.7
68.1
17.2
14.3
66.1
19.6
14.3
65
20.7
14.3
63.6
22
14.2
60.6
25.2
13.7
59.5
26.9
13.1
59.5
27.4
0%
20%
40%
60%
80%
100%
1995 2000 2005 2010 2015 2020 2025 2030
< 일본의 향후 인구비율 >
고령인구의 증가율 (7%->14%)스웨덴 85 년영 국 45 년일 본 24 년한 국 ? 년
65 세 이상 ( 노년인구 )
15∼65 세
0∼14 세 ( 소년인구 )
( 일본 국세도회 2000/2001)
고령인구증가
질병발생빈도증가
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Life Span & Quality by Medical Treatment
Life Span50 80
LifeQuality
과거 현재 21 세기
치료의학
예방의학 재활의학 산업적효과
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0
10
20
30
40
50
60
1995 1997 1999 2001 2003 2005 2007 2009
Year
Market Size(billion $)
World Market Size of Biomaterials
• 연평균 성장률 15% • 2000 년도부터는 예측한 값 ( 미국 , DATAMONITOR, Inc., 조사자료 )
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Applications of Biomaterials
재건장치 50%
기타 10%척추 이식재 6%
외상 관련 14%
연 조직 관련 10% 관절내시경 및 스포츠약품 10%
☞ 최근 아시아를 중심으로 수요의 급증으로 세계시장이 15% 안팎의 성장을 보임 (2000 년 2 분기 , Biomet Inc. 조사 )
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Current Trend of Bio R&D
• Gene Theraphy - Congenital Deformity/Disease
• Biomaterials - Congenital Deformity/Disease- Postnatal Deformity/Disease
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BiomaterialsBiomaterials
Tissue Tissue Engineering Engineering
Grafting
Current R&D Trend of Biomaterials
Natural & Artificial Biomaterials
Tissue/Organ
Scaffold
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Organization of Human Body
Organism
Molecule
Organelle
Cell
Tissue
System
Organ
Atom
Macromolecule
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Structure of Human bodyStructure of Human body
BodyBody
SystemSystem
Organ
Tissue
Cell Cell ++ MatrixMatrix
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Nervous System 신경 계통
Body Systems
Integumentary System 피부 계통
Skeletal System 골격 계통
Urinary System 비뇨기 계통
Digestive System 소화기 계통
Lymphatic System 림프 계통 / 면역 (Immunity)
Endocrine System 내분비 계통
Respiratory System 호흡기 계통
Cardiovascular System 심장 계통
Reproductive System 생식 계통
Muscular System 근육 계통
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Throx & Sternum 흉과과 흉골
Pelvis 골반Vertibra (lumbar part) 헉추 ( 요추 )
Head 두부
Femur 대퇴골
Neck 경부Temporomandibular joint 악관절
Shoulder joint 견관절
Ankle joint 거퇴관절
Elbow joint 주관절
Tibia & Fibula 경골과 비골
Hand (manus) 손Forearm 전완 (antibrachium) Hip joint 고관절
Elbow joint 주관절
Radiocarpal joint 요골수근관절
Foot 발
Arm (brachium) 상완
Shoulder girdle 상지대
Vertibra 척추 ( 경추 )(cervical part)
Intervertibral discs추간원판
Skeletons & Joints (articulations)
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영 남 대 학 교YE
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Functions of Bones
• Support : internal framework
• Protection : soft body organs
• Blood cell formation in marrow cavities
• Movement : body with muscle, tendon, ligament
• Storage : fat in cavities of bones Ca, P in bone self
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ImplantImplant
Surgical ProcedureSurgical Procedure
InflammationInflammation
Normal Wound HealingNormal Wound Healing Chronic IrritationChronic Irritation
HealingHealing Implant RemovalImplant Removalor Destructionor Destruction
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Why Increase the Use of Biomaterials ?
• Increase old ages• Increase of the wounded by war/accident• Health insurance • Pursuit of better quality of life• Development of new biomaterials
& medical technology
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Why Use the Artificial Biomaterials ?
(problems of the use of natural materials)
• Shortage of natural biomaterials• High cost• Immunologic reactions• Possible viral transmission
• Social and ethical problems
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Hyroxyapatite, CaHyroxyapatite, Ca1010(PO(PO44))66(OH)(OH)22
Main component of bone Main component of bone and tooth mineralsand tooth minerals Ca/P ratio : 1.67Ca/P ratio : 1.67
Excellent biocompatibilityExcellent biocompatibility
Chemically similar to bonChemically similar to bon
ee ~ 97 wt % of enamel~ 97 wt % of enamel ~ 69 wt % of cortical bon~ 69 wt % of cortical bonee
InorganicInorganic69 % (HA)69 % (HA)
waterwater 9 %9 %
organicorganic(collage(collagen)n) 22 %22 %
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Structure of Long Bone
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Various Forms of HA for Various Forms of HA for ApplicationsApplications
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Dental Implants by
Branemark System
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Various Porous Coating for ImplantsVarious Porous Coating for Implants
(ref) The biomedical engineering handbook, 683 (1995)
plasma sprayed sintered wire mesh sintered beads
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Metallic Bead Coating for ImplantsMetallic Bead Coating for Implants
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HA Coating for ImplantsHA Coating for Implants
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Comparison Between Comparison Between HA Un-coated & Coated ImplantsHA Un-coated & Coated Implants
S.S.Fibrous tissue Bone
BoneHA Coated S.S.
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Bone Bonding to HA-ImplantsBone Bonding to HA-Implants
HA
BM
150 μm
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BoneTiimplant
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Ear Prosthesis using Branemark System
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Nasal Prosthesis using Branemark System
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Tissue Regeneration Therapy
MonoclonalMonoclonal AntibodiesAntibodies (MAb)(MAb)
Isolation andIsolation andPurificationPurification
Harvest boneHarvest bonemarrowmarrow
MSCsMSCs
MarrowMarrowMesenchymalMesenchymal
Stem Cells (MSCs)Stem Cells (MSCs)
Cryo-PreserveCryo-Preservefor future use Culture-Expanded MSCsCulture-Expanded MSCs
Repopulate marrowRepopulate marrow Push to OsteoblastPush to Osteoblast Push to ChondrocytePush to Chondrocyte
HemapoiesisHemapoiesisSupportSupport
Normal boneNormal boneHomeostasisHomeostasis(Anti-aging)(Anti-aging) MassiveMassive
bone repairbone repair
Repair cartilage Repair cartilage defectdefect
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Porous Ceramic Assay
DispersedDispersedMarrowMarrow
DisectDisectPeriosteumPeriosteum
PorousPorousCeramicsCeramics
MSCsMSCs
PassagePassage
SubcutaneousSubcutaneous
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Porous CMP block
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Tissue Engineering
• Generation of new tissue substitutes for the replacement & repair
of lost or damaged tissue
Cell + Scaffold = Tissue natural ECM synthetic ECM
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Goal of Tissue Regeneration
(Man-made) (God-made)
by tissue engineering
CellCellSynthetic ECMSynthetic ECM
CellCellNatural ECMNatural ECM
CellCellNatural ECMNatural ECM
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Autogenic Autogenic MaterialsMaterials
Tissue EngineeredTissue EngineeredMaterialsMaterials
Osteoconductive MaterialsOsteoconductive Materials - allogenic - allogenic - synthetic - synthetic
++Osteoinductive MaterialsOsteoinductive Materials - - DBMDBM - - BMPBMP
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Porous Ceramic Assay
DispersedDispersedMarrowMarrow
DisectDisectPeriosteumPeriosteum
PorousPorousCeramicsCeramics
MSCsMSCs
PassagePassage
SubcutaneousSubcutaneous
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인간유전자 구조
염기체
유전자
염색체
세포핵
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Genome 관련 용어(Gene + Chromosome)
• 염색체- 유전자를 담고있는 그릇으로 세포의 핵속에 위치- 부계 및 모계로부터 각각 23 개씩 모두 46 개의 염색체
• 유전자- 단백질 합성 등 생체기능을 주관하는 유전정보의 최소단위- 염기체 수천 - 수만개가 하나의 유전자를 형성- 인간에게 모두 약 10 만개의 유전자가 있다
• DNA 염기서열- 인간유전자는 약 30 억개로 네 종류의 염기체가 일정한 순서로 배열 - 유전자를 구성하는 염기체는 아데닌 (A), 구아닌 (G), 시토신 ©, 티민 (T)- 염기서열에 따랄 키와 피부색깔 등 생물학적 특성이 결정 .
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• 신약개발 - 백혈병 / 빈혈치료제
• 맞춤 의약품 - 개인유전자 특성에 따른 질병치료약
• 유전자 진단 및 치료 - 잘못된 유전자를 정상유전자로 대체 - 암유전자 4 만개 발견 - 각종 유전질환인자 약 8 – 10 만개
유전자 정보의 상품화
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유전자 지도
책 ( 지식 ) 유전자 ( 생명의 비밀 )
한글 자음모음 DNA 염기서열단어 유전자문장 단백질의 기능
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Thank You 감사합니다