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ZIKA & CHIKUNGUNYA
Valentina Metsavaht Cará
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ZIKA & CHIKUNGUNYAArbovirus: Arthropod-borne viruses.Mosquito Aedes sp. (A. aegypti ou A. albopictus).
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ZIKA VÍRUS ZIKV Isolado de macaco rhesus por acasao, na
floresta Zika (Uganda) em 1947 O primeiro caso humano foi detectado na Nigéria,
em 1954.
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ZIKA VÍRUS
Séc XX
Séc XXI20142007
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ZIKA VÍRUS: classificação Familia Flaviviridae; genus Flavivirus (Febre Amarela,
Dengue, West Nile Virus) RNA fita simples – polaridade positiva Envelopado, icosaédrico
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ZIKA VÍRUS: biossíntese
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ZIKA VÍRUS: biossíntese
Pouco se sabe sobre biossíntese e patogenicidade do ZIKV. Como outros flavivírus, há diferentes receptores que podem mediar a entrada do vírus nas células - DC-SIGN, AXL, Tyro-3, TIM-1 – através de sinalização com a Proteína E do envelope.
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Estudos demonstraram que algumas células são permissivas à entrada do vírus, como fibroblastos da derme, células dendríticas imaturas, queratinócitos epiteliais vacuolização
Autofagossomos replicação viremia
ZIKA VÍRUS: biossíntese
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ZIKA VÍRUS Indução do Estado Antiviral vs. resistência a
tratamento com Interferons Tipo I e II
Fibroblastos infectados com ZIKV produzem IFN-α e IFN-β, além de citocinas inflamatórias como CCL5 e interleucina-1β (inflamassomo)
A esclarecer: relação do vírus com outras células: epitélio urogenital, células neurais em desenvolvimento
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ZIKA VÍRUS: transmissão Picada da fêmea do mosquito Aedes Vertical (Transplacentária) Sexual Transfusão
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RNA de ZIKV identificado no sêmen por muito tempo após infecção: não necessariamente relacionado com infectibilidade
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ZIKA VÍRUS: quadro clínico Assintomático (80%) Duração dos sintomas: até 1 semana
(coincide com a viremia)
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ZIKA VÍRUS Microcefalia
Em 27 de janeiro de 2016 o Brasil reportou 4180 casos suspeitos
demicrocefalia,
contrastando com a média de 163 casos
reportadosnacionalmente por ano.
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ZIKA VÍRUS: Guillain-Barré
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ZIKA VÍRUS - diagnóstico
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ZIKA VÍRUS - diagnóstico
Tratamento
sintomático e
acompanhamento
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CHIKUNGUNYA“Aqueles que se dobram” (dialeto Makonde)
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CHIKUNGUNYA Casos humanos com febre, erupção cutânea e artrite
aparentando ser CHIKV foram relatados no início de 1770.
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CHIKUNGUNYA - transmissão Picada pela fêmea do mosquito Aedes Vertical
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CHIKUNGUNYA - classificação Familia Togaviridae; genus Alphavirus RNA linear fita simples – polaridade positiva Envelopado, esférico
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CHIKUNGUNYA - biossíntese
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CHIKUNGUNYA - patogênese Linf. T CD8+, CD4+,
NK Resposta massiva de
monócitos/macrófagos inflamação crônica tecido sinovial
IF-α, IL-4, IL-10, IL-6, IL-8, CCL2,
Metaloproteinases Resposta imunológica
tipo Th-1 desregulada: processo nocivo por meses
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CHIKUNGUNYA – quadro clínico
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CHIKUNGUNYA – quadro clínico 30% assintomáticas Fase aguda: até 12 dias. Artrites/ artralgias
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CHIKUNGUNYA – quadro clínico Fase crônica: pode durar meses Complicação: Artrite Reumatóide
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CHIKUNGUNYA - diagnóstico Diagnóstico é clínico. Testes laboratoriais
apenas para casos graves/atípicos
Tratamento
sintomático e
acompanhamento
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PREVENÇÃO
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