Dr Kosei Hasegawa (GOTIC)

• T cells: CD8 vs CD4

• APC - DC, macrophages, monocytes

• Regulatory immune cells – Treg, MDSC, M2Mo

• Tumor cells• Tumor cells

•

• NK, NKT, gdT

• B cells

• Stromal cells (CAF, TEC)

Dr Kosei Hasegawa (GOTIC)

TILs in OC - Haminishi 2007

• Ten studies, 1815 OC patients

• significant advantage if TILs present

Neoantigen load - newly formed antigens which Neoantigen load - newly formed antigens which have not been recognised by the immune system

Anti-genome and immunome analysis

Dr Masaki Mandai (JGOG)

Dr Masaki Mandai (JGOG)

Global MTAs

Dr Kosei Hasegawa (GOTIC)Dr Masaki Mandai (JGOG)