Elsevier. Обзор

28 сентября 2016

Москва, Российская Федерация

Марат Фатхуллин

Директор по работе с государственными и образовательными организациями

M.Fatkhoulline@elsevier.com

+7 495 724 4169

www.elsevierscience.ru

От информации к решениям

1665: Первый

рецензируемый журнал

Наши дни: Информационные Решения для науки

Высококачественный научный контент

Инструменты принятия

решений

Услуги

Решения

Поиск, взаимодействие

Аналитика

ScienceDirect – 25% мировой научно-технической и медицинской информации

Количественные и качественные

показатели развития науки в виде

количества опубликованных статей

и количества цитирований (в т.ч. и

по БД Scopus) введены в

государственные регулирующие

документы

Сравнительные данные

Scopus 24,169

БК 12,491

Scopus

7,410 (+78%)

БК

4,188

Scopus

6,740 (+97%)

БК

3,415

Scopus

4,436 (+50%)

БК

2,954

Scopus

7,684 (+90%)

БК

4,016

Физические науки Медицина Науки о жизни Социогум. науки

~12K названий

3,300 издательств

Еженедельное

обновление

~24K названий

>5,000 издательств

Ежедневное

обновление

Источник: Web of Science Real Facts, списки журналов Web of Science и Scopus April 2014)

Ближайший конкурент

6

EMBASE IS AS COMPREHENSIVE AS POSSIBLE

PRESENTER | DATE | NAME OF PRESENTATION

Percentage of relevant articles retrieved

0 % 50 % 100 %

Eff

ort

/ t

ools

requir

ed

GOOGLE

EMBASE

PUBMED

SOURCE

SCOPUS

TEXT MINING

Serving the life sciences space ADDRESSING KEY CHALLENGES ACROSS THE R&D VALUE CHAIN

Characterize & discover

molecules

Identify & confirm lead

compounds

Translate preclinical

data in humans

(Translational)

Characterize

targets & analyze

disease pathways

Monitor drug

adverse events &

real-world evidence

data in literature

Integrate the

world of data &

solutions

Drug Candidate Selection Go-No Go Decision

Preclinical Data Validation Managing risk

Text Mining & Data Integration

Discovery Pre-clinical Clinical Post-launch

Search full-text, peer-

reviewed journal

articles

Largest database for access

to abstract & citation data

Broader full-text

indexing of biomedical

content

7

8

Choosing one wrong target costs time(2½yrs) & money ($3.5M) and has more substantial repercussions ($254M and 13yrs lost) in the long term. Reducing the risk by increasing knowledge around targets from the start is pivotal in drug discovery.

FINDING GOOD TARGETS REMAINS A CHALLENGE

30% of Phase II failures from 2008-2010 were

related to validated targets

“Large numbers of failures are occurring with drugs

that have novel mechanisms of action in areas of high unmet medical need..”

REAXYS

UNFOCUSED RESULTS

BIBLIOGRAPHIC

APPROACH

USE-CASE DRIVEN

ACROSS TIME/LITERATURE

ESSENTIAL TITLES

Structured to help you search

50,000,000 RESULTS RETURNED

FURTHER SEARCH

NEEDED

CATALOGUED AND TAXONMISED BY CHEMISTS FOR CHEMISTS

OTHER DATABASES

9

RELEVANT ANSWERS

Extract title and abstract enabling

researchers to do extended bibliographic

search across all scientific domains.

Providing

access to journals you wouldn’t consider

searching for.

Facts

Facts

Facts

15,973 PERIODICALS COVERING

• AGRICULTURAL AND BIOLOGICAL SCIENCES

• BIOCHEMISTRY, GENETICS AND MOLECULAR BIOLOGY

• CHEMICAL ENGINEERING

• CHEMISTRY

• DENTISTRY

• EARTH AND PLANETARY SCIENCES

• ENERGY

• ENGINEERING

• ENVIRONMENTAL SCIENCE

• IMMUNOLOGY AND MICROBIOLOGY

• MATERIALS SCIENCE

• MEDICINE

• NEUROSCIENCE

• PHARMACOLOGY, TOXICOLOGY AND PHARMACEUTICS

• PHYSICS AND ASTRONOMY

• VETERINARY

REAXYS 2013 NOW REAXYS SOURCES RELEVANT CHEMISTRY INFORMATION FROM ADJACENT SCIENTIFIC

FIELDS, BRINGING THEM WITHIN REACH OF THE CHEMISTRY RESEARCHER

A universe of chemistry information

CHEMISTRY RESEARCHER

CHEMISTRY

• 400 CORE JOURNALS

• RELEVANT CHEMISTRY PATENTS

• HISTORICAL CHEMISTRY DATA (FROM 1771)

10

MANY WAYS TO ASK YOUR QUESTIONS

Reaxys home page:

Data search

form by subject

Perform a

literature

search

Open a

structure

search form

11

Open Reaction

search form

UNDERSTAND

EXPERIMENT REPORT &

COMMUNI-CATE

Search using

chemical

identifiers

Ask Reaxys, a quick

‘concept search’

Browse database via

taxonomies rather

than search

database

Chemistry as the organizing principle

Reaxys design

Physical Data

Bioactivity Data

Spectra

Natural Product

Physical Data

Spectra

Bioactivity Data

Natural Product

Reaxys

With experimental data from journal articles and

patents

Reaxys is built

Chemistry as the Organizing Principle

Chemical Structures

Chemical Syntheses

Physicochemical Properties

Pharmacology

Reaxys excerpts

all relevant data

even from

footnotes and text

PROPERTIES OF COMPOUNDS

15

Reaxys

16

… But it's not that simple, medicinal chemists for instance need to collect, organize and compare information from different sourceS… this is time consuming and error prone

?

? ?

?

… But it's not that simple, medicinal chemists for instance need to collect, organize and compare information from different sourceS… this is time consuming and error prone

17

18

And to Make a decision on which experiment to do, you want to organize your content, normalize and compare, to understand which compound interacts with which target and trigger which biological effect—that's a lot of manual work!

DR. OLIVIER BARBERAN | RMC 2014| ELSEVIER

Искать и анализировать

научную информацию

Читать и обрабатывать

полнотекс-товые статьи

Собирать и хранить статьи

Писать научную работу

Подавать статью в науный журнал

Оценивать и публиковать

Управлять карьерой и сетью

коллег

19

Этапы научно-исследовательской деятельности

Корреляции при осуществлении доступа

к мировому научному контенту

Экономическое развитие региона/отрасли

Публикация статей

Доступ к электронному контенту

Чтение научных статей

Расходы на R&D

Примеры: Южная Корея, Бавария

Спасибо за внимание

www.elsevierscience.ru