enzim 1
DESCRIPTION
untuk memenuhi tugas biokimia dengan judul enzimTRANSCRIPT
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ENZIMOleh :
Vyta Andri S.U (12317244003)
Opik Prasetyo (12317244006)
Fatharani Y. W. (12317244013)
Marbelisa Briliani (12317244020)
Shintya Galuh N.S. (12317244028)
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PENGANTAR
• APA ITU ENZIM ???
1. ENZIM = PROTEIN PROTEIN ENZIM
2. BIOKATALISATOR
![Page 3: ENZIM 1](https://reader036.vdocuments.pub/reader036/viewer/2022062805/55cf93c1550346f57b9e4759/html5/thumbnails/3.jpg)
Tidak Semua Protein = Enzim
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E S
ES
E E
Produk
![Page 5: ENZIM 1](https://reader036.vdocuments.pub/reader036/viewer/2022062805/55cf93c1550346f57b9e4759/html5/thumbnails/5.jpg)
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SIFAT-SIFAT ENZIM
• 1. Mempercepat reaksi dengan menurunkan energi aktivasi
• 2. Memiliki sensitivitas yang tinggi terhadap substrat
• 3. Biokatalisator
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1. Mempercepat reaksi dengan menurunkan energi aktivasi
![Page 8: ENZIM 1](https://reader036.vdocuments.pub/reader036/viewer/2022062805/55cf93c1550346f57b9e4759/html5/thumbnails/8.jpg)
2. Memiliki sensitivitas yang tinggi terhadap substrat
![Page 9: ENZIM 1](https://reader036.vdocuments.pub/reader036/viewer/2022062805/55cf93c1550346f57b9e4759/html5/thumbnails/9.jpg)
3.Biokatalisator
![Page 10: ENZIM 1](https://reader036.vdocuments.pub/reader036/viewer/2022062805/55cf93c1550346f57b9e4759/html5/thumbnails/10.jpg)
KOMPOSISI ENZIM
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Komponen Enzim
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PENGGOLONGAN ENZIM BERDASARKAN IUMB
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NAMA GOLONGAN KODEJENIS REAKSI YANG
DIKATALISISNYA1. Oksido - Reduktase (Reaksi
oksidasi reduksi)
1.1 bekerja pada CH-OH1.2 bekerja pada C=O1.3 bekerja pada C=CH1.4 bekerja pada C-NH21.5 bekerja pada CH-NH
1.6 bekerja pada NADH;NADPH
2. transferase (mentransfer gugus fungsi)
2.1 gugus satru karbon2.2 gugus Aldehid / keton2.3 gugus Asil2.4 gugus glikosil
2.7 gugus fosfat
3. Hidrolase (reaksi hidrolisis)
2.8 gugus yang mengandung –S3.1 Esther 3.2 ikatan glukosidik3.4 ikatan peptide3.5 ikatan C-N lain
4. Liase (adisi pada ikatan rangkap)
4.1 C=C4.2 C=O
4.3 C=N
5. isomerase (reaksi isomerisasi) 5.1 Rasemase6. ligase (pembentukan ikatan
dengan menguraikan ATP)
6.1 C-O6.2 C-S6.3 C-N
6.4 C-C
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TATANAMA ENZIM
• BERDASARKAN SUBSTRAT
• TIDAK BERDASARKAN SUBSTRAT
![Page 15: ENZIM 1](https://reader036.vdocuments.pub/reader036/viewer/2022062805/55cf93c1550346f57b9e4759/html5/thumbnails/15.jpg)
• Berdasarkan substrat
SUBSTRAT + ASE
2(C6H10O5)n + n H2O n C12H22O11
Amilum Maltosa
C12H22O11+ H20 2C6H1206
Maltosa Glukosa
Maltase
Amilase
![Page 16: ENZIM 1](https://reader036.vdocuments.pub/reader036/viewer/2022062805/55cf93c1550346f57b9e4759/html5/thumbnails/16.jpg)
• Tidak berdasar substrat : pepsin
tripsin
papain
bromelin
![Page 17: ENZIM 1](https://reader036.vdocuments.pub/reader036/viewer/2022062805/55cf93c1550346f57b9e4759/html5/thumbnails/17.jpg)
• E + S ES
• ES P + E
•E + I EI E+I
Teori Umun Kerja Enzim
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MEKANISME REAKSI ENZIM
• 1. LOCK AND KEY MODEL
• 2. INDUCED FIT MODEL
• 3. REAKSI ENZIMATIK DENGAN DUA SUBSTRAT
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Gambar sisi aktif enzim
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LOCK AND KEY MODEL
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INDUCED FIT MODEL
![Page 23: ENZIM 1](https://reader036.vdocuments.pub/reader036/viewer/2022062805/55cf93c1550346f57b9e4759/html5/thumbnails/23.jpg)
Reaksi enzimatik dengan dua substrat
E E
EE
E E
E E E
E E E
Reaksi berganti-tunggal Reaksi berganti-ganda (ping-pong)
A + B C + D AX + B A + BXA
A BA
BA
+ C+D
B
AX AX XA
B X BX
BX
A
![Page 24: ENZIM 1](https://reader036.vdocuments.pub/reader036/viewer/2022062805/55cf93c1550346f57b9e4759/html5/thumbnails/24.jpg)
KINETIKA ENZIM Michaelis-Menten
Vo = Vmaks [S] Km + [S]
Jika Km=[ S ], maka
Vo = ½ Vmaks
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TRANSFORMASI PERUBAHAN HUKUM MENTENLineweaver-Burk double reciprocal plot
Y = m x + b
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FAKTOR YANG MEMPENGARUHI KERJA ENZIM
• 1. pH
![Page 27: ENZIM 1](https://reader036.vdocuments.pub/reader036/viewer/2022062805/55cf93c1550346f57b9e4759/html5/thumbnails/27.jpg)
Rate
of
React
ion
2.Suhu
0 20 30 37
5010 40 60
40oC - denatures
5- 40oC Increase in Activity
<5oC - inactive
![Page 28: ENZIM 1](https://reader036.vdocuments.pub/reader036/viewer/2022062805/55cf93c1550346f57b9e4759/html5/thumbnails/28.jpg)
• 3. Konsentrasi substrat
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• 4. Konsentrasi enzim
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5. Aktifator
AKTIFATOR
Koenzim
kofaktor
Molekul anorganikContoh: Fe3+ , Cu2+ , Zn2+ , Mg2+ , Mn2+
Molekul organik
Contoh: Tiamin pirofosfat, Koenzim A, Biositin, Tetrahidrofolat
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6. INHIBITOR
IRREVERSIBLE REVERSIBLE
-Kompetitif
-Non-kompetitif
-Un-kompetitif
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IRREVERSIBLE INHIBITOR
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REVERSIBLE INHIBITOR
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1. Penghambatan competitive
V max = tetapKm = diperbasar
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2. Penghambatan Non-competitive
Vmax = diperkecil Km = tetap
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3. Penghambatan Un-competitive
Vmax & Km = diperkecil