experience with large scale plasmapheresis from vnrbd, dr p
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Experience with large scale plasmapheresis from voluntary non-remunerated donors
Ruud van Dongen, Paul Strengers
Sanquin Blood Supply Amsterdam,
The Netherlands
IPFA/BCA Global Symposium 2014 23 September 2014
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Sanquin Blood Supply
• Division Blood Bank • Division Diagnostic Services • Division Research • Division Reagents • Division Plasma products
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Blood Bank division
Blood collection • Recruiting and medically examining donors • Collecting blood and plasma
Products and supply • Production and testing blood and blood products • Stock management • Supplying products and services to hospitals and other customers
Education and advice • Giving advice to customers about products and offering services
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P/I/C region 1
P/I/C region 2
P/I/C region 3
P/I/C region 4
R&D blood transfusion technology
Tissue Bank
QA & RA region 1
QA & RA region 2
QA & RA region 3
QA & RA region 4
KCD / MA region 1
KCD / MA region 2
KCD / MA region 3
KCD / MA region 4
DA region 1
DA region 2
DA region 3
DA region 4
Organization Executive Board/Director
IC-BB Release management
Secretariat Consulting Services
Donor Affairs QA and RA Production DTM/
Medical affairs
IC-BB=Information Centre Blood Bank, P/I/C = Processing/Issue/Customer service, DTM= Department of Transfusion Medicine, QA/RA=quality assurance, regulatory affairs
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Activities of the blood bank
• Responsible for the recruitment of donors and the collection of blood and plasma
• After being collected, the blood is tested and processed into red cell concentrates, platelets and plasma
• The blood compnents are supplied to Dutch hospitals, and plasma to the Sanquin Division of Plasma Products for the manufacturing of plasma derived medicinal products
• Hemovigilance (registration of complications as a result of transfusions of blood products) is taking place together with TRIP (Transfusion Reactions in Patients)
• Advising physicians and foreign organizations with respect to blood supply
• Related activities: Umbilical cord blood bank, Bone marrow bank, Bone bank
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2013
• Blood Bank Division has four main collection locations: Amsterdam, Rotterdam, Nijmegen and Groningen
• 56 permanent collection points and 108 mobile ones
• Number of employees: +/- 1,400
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Key figures blood supply 2013 (1)
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Key figures blood supply 2013 (2)
Blood products
Use of red blood cell concentrates
448,488
Platelets (from whole blood in donor units)
264,906
Fresh frozen plasma 67,071 Kilograms plasma total (incl. apheresis) supplied to Plasma Products division
308,895
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Usage
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Number of donations 2009-2013
Total number of donations
Number of whole blood donations
Number of apheresis donations
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Frequency of donation of whole blood donors
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Frequency of donation of plasma donors
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Donation criteria and frequency
• Age: 18-65 (70)
• Health check (questionnaire, blood pressure, heart rate, Hb, lab tests)
• Donation criteria whole blood: 5 times per year
3 times per year plasmapheresis: 23 times per year, once every
two weeks
• Avarage donation frequency: whole blood 1.7 / year plasmapheresis 5.5 / year
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Plasma donor program
• Information • Donor selection criteria almost equal to whole blood donation (quarantine
plasma only male plasma) • Preference for converting whole blood donors to plasma donors • Plasmapheresis only on appointments made • Either whole blood or plasma donation • Immunization program for hyper immune plasma donors (hepatitis B,
tetanus, Rhesus (D).
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Recruitment plasma donors 400,000 donors (2,3% of the population)
355,000 whole blood donors
45,000 plasma donors
Recruitment from whole blood donors
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The process of annual planning
1. Projection of demand of red cells and FFP, and of PfF
2. Determination of number of donations of WB and of collections of plasma
3. Mobile sites:
Determination of number of WB donors needed per location x 1.3 = collection at mobile sites
5. Fixed sites
Start with the nr of Plasma donors. Plasma donors per location x 5.0 = collection of plasma.
4. Total collection – mobile collection = fixed site collection of WB.
7. WB collection per fixed is nr of donors x 1.5-1.8. The exact collection depends also on the number of sessions per week.
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Fixed blood collection center
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Mobile blood collection center
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Interior of mobile blood collection center
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Plasma collection (apheresis)
Haemonetics PCS2 and MCS+ • Total 239 machines (60% of total) • Collected volume 650 / 630 ml
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Plasma collection (apheresis)
Fresenius (Fenwal) Autopheresis C
• Total 154 machines (40% of total) • Collected volume 650 ml
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We need more plasma donors. Has the donor assistant asked you already to become a plasma donor? Ask him or her for more information.
Will you marry me? Or
Please say yes to a life-changing
proposal?
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Thank you for your attention