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Fast ConvenienceEfficient Economic Which One Slide 2 Library of CAMS/PUMC Apr. 18, 2012 Slide 3 What is the Literature? How to find ? How to evaluate ? How to read ? How to analysis ? How to manage ? Slide 4 About the Literature Slide 5 Come from Study (evidence) Original Randomized Controlled Trials(RCT) Cohort Study Retrospective Study(case control) Slide 6 Come from Study (evidence) 2nd Systematic Reviews Meta Analysis Clinical Practice Guideline CPG Slide 7 Come from Study (evidence) 3rd News Meeting Bibliography Database Slide 8 Level of Study (evidence) Slide 9 About the Literature Slide 10 About Search -PubMed Slide 11 NCBI National Center for Biotechnology Information General Introduction Established on 1988, as a division of the National Library of Medicine (NLM) at the National Institutes of Health (NIH). Http://www.ncbi.nlm.nih.gov Slide 12 NCBI National Center for Biotechnology Information General Introduction Conducts research on fundamental biomedical problems at the molecular level using mathematical and computational methods Maintains collaborations with several NIH institutes, academia, industry, and other governmental agencies Fosters scientific communication by sponsoring meetings, workshops, and lecture series Supports training on basic and applied research in computational biology for postdoctoral fellows through the NIH Intramural Research Program Slide 13 NCBI National Center for Biotechnology Information General Introduction Engages members of the international scientific community in informatics research and training through the Scientific Visitors Program Develops, distributes, supports, and coordinates access to a variety of databases and software for the scientific and medical communities Develops and promotes standards for databases, data deposition and exchange, and biological nomenclature Slide 14 NCBI National Center for Biotechnology Information Entrez ( Cross-Database Search System ) It is a powerful federated search engine, or web portal that allows users to search many discrete health sciences databases at NCBI website. Slide 15 Slide 16 NCBI National Center for Biotechnology Information Slide 17 General Introduction Over 20 million citations from MEDLINE (1966-) and additional life sciences journals (1865-) MEDLINE + PreMEDLINE + HyperLink Slide 18 General Introduction More than 80 countries,50 languages, 23.7 thousand journals It`s FREE !! HOW to USE Slide 19 Slide 20 Search Fields Text WordsMeSH Title / Abstract Words AuthorAffiliationPublication Date IssueLanguageSubstance Name Page No.EC/RC No.Publication Type Journal TitleSubheadingsUnique Identifiers Volume Slide 21 Boolean Search AND OR NOT Slide 22 How do I search PubMed? Identify the key concepts for your search. Enter the terms (or key concepts) in the search box. Click Search to run this search in PubMed. Slide 23 Sample Stomach Cancer Stomach Tumor Stomach Tumour Stomach Neoplasm(s) Slide 24 Stomach Cancer OR Stomach Tumor OR Stomach Tumour OR Stomach Neoplasm? Slide 25 Slide 26 Journal Title Publication Date Title Words Authors Affilication Abstract Unique Identifiers Search the same topic articles from Title\Abstract\MeSH Slide 27 FullText HyperLink LinkOut Slide 28 Slide 29 Slide 30 Slide 31 WHY there are so many articles not I want? The garbage articles make me boring!! Slide 32 More Exactly? Stomach Cancer Stomach Cancer Stomach Tumor Stomach Tumour Stomach Neoplasm(s) Stomach Neoplasms MeSH Slide 33 MeSH (Medical Subject Headings) Controlled vocabulary of biomedical terms that is used to describe the subject of each journal article in MEDLINE There are 26,142 descriptors in 2011 MeSH Slide 34 Slide 35 Slide 36 Controlled Standardized Slide 37 Slide 38 Stomach Cancer Slide 39 Slide 40 Slide 41 Subheadings Narrow the specific focus of a main topical heading to a particular aspect of the subject. There are 83 topical qualifiers http://www.nlm.nih.gov/mesh/topsu bscope.html Slide 42 Slide 43 Tips OperationSurgery (Subheadings) Drug/adverse effects Therapy Method/adverse effects Disease/complication Slide 44 Sample Therapy or Nursing on Stomach Cancer Slide 45 Slide 46 Slide 47 Slide 48 Slide 49 Slide 50 How to focus on my search? Limits Slide 51 Slide 52 Slide 53 Tips Clinical Queries Single Citation Matcher Slide 54 Slide 55 Slide 56 Slide 57 If I only know the title, how to search the article? Single Citation Matcher Slide 58 Slide 59 Slide 60 Sample 2008;5;387-? Slide 61 2008 5 387 Slide 62 Slide 63 Can I save my results & habits? My NCBI Slide 64 Slide 65 Slide 66 Slide 67 Slide 68 Slide 69 Slide 70 Slide 71 Slide 72 Slide 73 Slide 74 Slide 75 Slide 76 Slide 77 meta Slide 78 Recommend Slide 79 Slide 80 F1000 (Faculty of 1000) Continuously updated selections and evaluations of the most important articles Attributed opinions and expert knowledge from global leaders in biology and medicine Site customization and email alerts based on user interests Recommendations and interpretations based on the article's merits, not the journal's Slide 81 Slide 82 Slide 83 Recommended 6-7 Must Read 8-9 Exceptional 10+ Slide 84 Slide 85 Slide 86 Slide 87 About the Literature About search Slide 88 About Evaluation Slide 89 Evaluation F1000 or F1000m SCIe Jadad Scale Slide 90 Slide 91 Slide 92 Slide 93 Slide 94 Slide 95 About Read Slide 96 Read Title Material & Method Outcome Discussion Slide 97 Jadad Scale 97 Jadad AR, Moore RA, Carrol D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary [J] Control Clin Trials, 1996, 17:112. Slide 98 Jadad Scale Grade Full Mark: 5 High Mark : 3 Low Mark: 2 : easy, abroad : lack of allocation concealment Slide 99 Jadad + Schulz Adequate Inadequate Unclear http://www.cochrane-handbook.org Slide 100 e.g. Title Randomized clinical trial of intravenous soybean oil ( )alone versus soybean oil plus fish oil emulsion ( )after gastrointestinal cancer surgery. Jiang ZM, Wilmore DW, Wang XR, et al. Br J Surg. 2010, 97(6):804-809. Slide 101 e.g. 101 Reference: Jiang ZM, Wilmore DW, Wang XR, et al. Randomized clinical trial of intravenous soybean oil alone versus soybean oil plus fish oil emulsion after gastrointestinal cancer surgery. Br J Surg. 2010, 97(6):804-809. Material & Method R DB Slide 102 Follow-up Slide 103 e.g. Jadad 2 2 1 5 103 Slide 104 e.g. 104 Reference: Jiang ZM, Wilmore DW, Wang XR, et al. Randomized clinical trial of intravenous soybean oil alone versus soybean oil plus fish oil emulsion after gastrointestinal cancer surgery. Br J Surg. 2010, 97(6):804-809. Material & Method Slide 105 e.g. Schulz Adequate 105 Slide 106 About the Literature About search About Evaluation About Read Slide 107 About Analysis Slide 108 How can I analysis the articles? Slide 109 GoPubMed Based on PubMed Database Gene Ontology AND MeSH Analysis It`s FREE!! www.gopubmed.com Slide 110 Slide 111 and 1000000 [maxdocs] Slide 112 Slide 113 Slide 114 Slide 115 Slide 116 Slide 117 Slide 118 Slide 119 Where r u? Slide 120 So Many PDFs, How to Manage them? Management Software Slide 121 About Management Slide 122 Slide 123 Slide 124 Slide 125 www.library.imicams.ac.cn Slide 126 Slide 127 Best Practice Cochrane MICROMEDEX Pier Slide 128 Slide 129 Slide 130 Slide 131 Slide 132 Slide 133 Slide 134 Slide 135 www.library.imicams.ac.cn Slide 136 Slide 137 What is the Literature? How to find ? How to evaluate ? How to read ? How to analysis ? How to manage ? Slide 138 Slide 139