FAST DISSOLVING ORAL FILMS

PRESENTED BY B.JAGADEESH BABUM.Pharm

OVER VIEWINTRODUCTIONSPECIAL FEATURESGENERAL PROPERTIESFORMULATIONMETHOD OF PREPARATIONEVALUATION TESTSADVANTAGES & DISADVANTAGESCONCLUSION

INTRODUCTION These are the drug delivery systems

which fastly disintegrate in mouth with H2O.

It was first developed in 1970’s alternative to tablets & capsules.

It consists of very thin oral strip which is placed on tongue & upon hydration it fastly releases drug into oral cavity.

Thin elegant film Available in various sizes & shapes Unobstrusive Excellent mucoadhesion Rapid release

GENERAL PROPERTIES

Thickness ranges from 1-10mm & it’s surface area is 1-20 cm².

Its low dry tack allows for ease of handling & application.

Its rapid hydration rate facilitates fast softening & absorption.

2mm thickness of film will take 5-10sec to start its disintegration.

FORMULATIONFORMULATIONDRUGWATER SOLUBLE POLYMERSUPER DISINTEGRANTSPLASTISIZERSURFACTANTSFLAVOURSCOLOURSSWEETENING AGENTSSALIVA STIMIULATING AGENTS

SOLVENT CASTING* SEMI-SOLID CASTING HOT MELT EXTRUSION SOLID DISPERSION EXTRUSION ROLLING METHOD

EVALUATION TESTSMORPHOLOGY STUDYSWELLING PROPERTYCONTACT ANGLEDISINTEGRATIONMECHANICAL PROPERTIES 1. Tensile strength 2.Elastic modulus 3.% Elongation 4. Folding endurance

Convenient dosing

No water needed

No risk of chocking

Taste masking

Enhanced stability

First pass metabolism can be avoided

Easily fragile & brittle.

Special package for protection during storage

& transportation.

These are having several advantages over conventional dosage forms like

ODT, TABLETS, CAPSULES ,IV etc., so they are of great importance during the emergency cases such as allergic reations & asthamatic attacks.