fdt eval.pdf

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Sci Pharm  www.scipharm.at  Review Open Access Mouth Dissolving Tablets II: An Overview of Evaluation Techniques Dali SHUKLA, Subhashis CHAKRABORTY, Sanjay SINGH, Brahmeshwar MISHRA * Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221005, India. * Corresponding author. E-mail: [email protected]  (B. Mishra) Sci Pharm. 2009; 77: 327–341 doi:10.3797/s cipharm.0811- 09-01 Published: March 6 th  2009 Received: November 6 th  2008  Accepted: March 5 th  2009 This article is available from: http://dx.doi.org /10.3797/scip harm.0811-09-02 © Shukla et al.; licensee Österreichische Apotheker-Verlag sgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Mouth dissolving tablets are well established dosage forms available in the market. The numerous advantages that they offer to the patients in terms of compliance as well as to the manufacturers in terms of huge revenues by line extension of products are well known. In spite of such popularity, there seems to be lack of a standardized system to characterize these dosage forms. Enormous work has been done in this field, wherein some of the researchers have developed their own methods of evaluation. This article attempts to present a detailed review regarding technological advances made so far in the area of evaluation of mouth dissolving tablets with respect to special characteristics of these unique dosage forms. In the absence of any available standardized method, the author’s recommendation on critical issues in the field may be considered. Keywords Mouth dissolving • Evaluation technique • Disintegration test • Taste masking • E-tongue Introduction Mouth dissolving drug delivery systems (MDDDS) are a new generation of formulations which combine the advantages of both liquid and conventional tablet formulations, and at the same time, offer added advantages over both the traditional dosage forms. They provide the convenience of a tablet formulation and also allow the ease of swallowing provided by a liquid formulation. MDDDS offer the luxury of much more accurate dosing than the primary alternative, oral liquids. This segment of formulation is especially

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