fondazione cnao trattamenti adroterapici e...
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Fondazione CNAO
Trattamenti adroterapici e ricerca
Ph.D. M. M. Necchi
Pavia, 20 Marzo 2019
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www.cnao.it
7 Novembre 2005 CNAO – Pavia
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www.cnao.it
Era il 1991…
ATER-INFN
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www.cnao.it
From 1996 to 1999 at CERN
PIMMS (Proton-Ions Medical Machine Study)
Objective: define the optimal hadrontherapy centre without constraints
CERN-GSI-MedAUSTRON-
Oncology2000-TERA
PL: P. Bryant (CERN+experts)
PAC: G. Brianti chairman
TERA: 25 manyrs
MedA.: 10 manyrs
O2000: 3 manyrs
GSI: experts advices
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www.cnao.it
Le fasi di CNAO
Fase 1: costruzione Anni: 2005 - 2010
Fase 2: sperimentazione Anni: 2010 - 2013
Fase 0: organizzazione Anni: 2002 - 2004
Fase 3: operatività Dal 2014 - …
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www.cnao.it
L’Alta Tecnologia del CNAO
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www.cnao.it
(courtesy of Siemens Medical)
Scansione attiva
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www.cnao.it
Flexible hightech design: compact solution
Linac
Treatment
Rooms
Synchrotron
Ion Sources
High
Energy
Transfer
Lines
Hospital based: safety, efficiency, reliability, maintainability
Commissioning in 2019
New experimental room (in collaboration with INFN)
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www.cnao.it
The synchrotron for protons and Carbon ions
7-250 MeV p
7-400 MeV/u C
I ~ 0.1-6 mA (p)
I ~ 0.03-1.5 mA (C)
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www.cnao.it
Performance CNAO from Nov. 2011 to Dec. 2018
2417 running days
1763 treatment days
161 days preventive maintenance
36 days of downtime
System availability: 92.4%
System reliability (days): 98.5%
System reliability (sessions)
322 days
240 days
32 days
0 days
90.9%
100%
97.0 % (314 vs 10442)
Year2018
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www.cnao.it
CNAO is Manufacturer of Medical Device (directive 93/42/EEC)
CNAO obtained the CE label after clinical experimentation
CE label is a good starting point to obtain FDA clearance
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www.cnao.it
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www.cnao.it
Photons Protons
Radioterapia vs protonterapia: quali vantaggi?
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www.cnao.it
Protons
Protons
X-rays
Pazienti pediatrici: protonterapia
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www.cnao.it
Ocular treatments with active scanning: FIRST TIME EVER !
Non invasive eye tracking system for intraocular tumour localization in
proton therapy treatments (Collaboration with PoliMi, Galliera, INT, Sacco, Krakow, UniPv and INFN)
250 patients/year
in Italy
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www.cnao.it
Il fascio del CNAO per attività clinica
Pazienti trattati all’anno
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www.cnao.it
Da Settembre 2011
Sono stati trattati più di 2100 pazienti, divisi per patologia
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www.cnao.it
Trattamenti, reirradiazioni,
particella
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www.cnao.it
Research is a must to keep CNAO up-to-date
to stay always at the cutting edge
The Centre technology needs to evolve and adapt according to the research
outcome: it is not a static “black box” producing beam, it is an evolving entity
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www.cnao.it
Research: hot topics
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www.cnao.it
Beamtime for research projects in 2018
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www.cnao.it
New projects: cutting edge technology !
Expansion Area 1
Expansion Area 2
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www.cnao.it
Initial work performed in collaboration
with TERA Foundation
Expansion Area 1
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www.cnao.it
Expansion Area 2
Initial work performed in collaboration
with TERA Foundation
Radioisotopes BNCT
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www.cnao.it
Expansion Area 2: BNCT@CNAO
Hadrontherapy+BNCT: clinical complementarity
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www.cnao.it
FORMATION at CNAO Collaboration with many Institutes and Universities
N. 11 visitators from abroad
Mean duration: 225 dd (5 to 1096 dd)
Project full title: MEDICIS-produced
radioisotope beams for medicine
Duration: 4 y; started April 2015.
At CNAO 1 ESR for 3 years: Personalized 11C PET aided hadrontherapy
Profile N. 37
Physicist 1
Medical physicist 3
Engineer 1
Biomedical engineer 1
TSRM 1
Physician 14
Radioterapista 3
Specializzando in Radiologia 5
Specializzando in RT 6
Students 16
Scienze biologiche 1
Ingegneria Fisica 3
Medicina e Chirurgia 7
Neurobiologia II 2
Scuole di II livello 1
TSRM 2
Project full title: Optimization of
Medical Accelerators
Duration: 4 y; started February 2016
At CNAO 2 ESRs for 3 years: Light ion
therapy software for data exchange and
Tumor tracking in particle therapy
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www.cnao.it
Progetto Laurea Magistrale Plus al CNAO
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www.cnao.it
1. Modulazione di intensità
Obiettivi del tirocinio:
Lo scopo primario del tirocinio è sviluppare
una versione sperimentale del Dose Delivery
in grado di comunicare col betatrone (parte
del sistema di estrazione del fascio) per
adattare in tempo reale l’intensità del fascio
estratto al fine di abbreviare i tempi di
trattamento.
Requisiti/ competenze tirocinante
- competenze di programmazione;
- basi di elettronica digitale;
- conoscenza della fisica dei rivelatori.
Potenziale ambito e argomento di tesi
Rivelatori; elettronica di trattamento del
segnale; sistemi di controllo e
programmazione.
Schoemers et Al, NIM A 795 (2015) 92-99
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www.cnao.it
2. Sviluppo, in collaborazione con l’INFN, di un monitor di fascio per calibrazione a basse intensità
Courtesy by Prof. G. Battistoni, INFN-MI
Obiettivi del tirocinio:
Lo scopo primario del tirocinio è sviluppare
l’elettronica di acquisizione e controllo di un
monitor composto presumibilmente da due
scintillatori in coincidenza in grado di contare
le singole particelle e fornire intensità media,
profilo temporale e posizione dei fasci in
condizioni di bassa intensità laddove il
monitor del Dose Delivery non rileva.
Requisiti/ competenze tirocinante
- competenze di elettronica nucleare;
- programmazione;
- buona conoscenza della fisica dei rivelatori;
- fondamenti di analisi dati.
Potenziale ambito e argomento di tesi
Rivelatori; fisica degli acceleratori;
elettronica nucleare; sistemi di controllo e
programmazione.
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www.cnao.it
HADRONTHERAPY MORE PRECISE ON TUMOUR
LESS INVASIVE ON THE PATIENT
@FondazioneCnao
@Fond_CNAO
Fondazione CNAO
Centro Nazionale di
Adroterapia Oncologica (CNAO)
www.fondazionecnao.it
@FondazioneCnao
@Fond_CNAO
Fondazione CNAO
Centro Nazionale di Adroterapia
Oncologica
First contact for medical infos:
+39 0382-078963
International Patients Office:
+39 0382-078306