funny neuron regeneration
DESCRIPTION
刘恋 2013.5.27. Funny Neuron regeneration. Outline. 1. What is neuron like?. 2. What is neuron damage?. 3. Why we cannot recover ourselves?. 4. Remaining questions. 5. Colorful world in our CNS. What is neuron damage. Spinal cord injury-- 2,0000 people per year in USA - PowerPoint PPT PresentationTRANSCRIPT
刘恋2013.5.27
Funny Neuron regeneration
Outline
4
What is neuron like?1
2
3
5
What is neuron damage?
Why we cannot recover ourselves?
Remaining questions
Colorful world in our CNS
What is neuron damage
Spinal cord injury--2,0000 people per year in USA Stroke ---700,000 people per year in USA third most common cause of death in USA
Why we cannot recover ourselveses ?
What is the main barriers for neuron regeneration
Main barriers for neuron regeneration
After injury ……what happens?
When the neuron is cut…
In the (Peripheral neuron system)PNS…
Nogo protein
Martin E. SchwabNature Reviews Neuroscience (December 2010)
Structure of nogo protein
Postmetamorphic frogs
Nogo protein
Martin E. SchwabNature Reviews Neuroscience (December 2010)
Intrinsic regeneration capacity
How did neuron know…?
” I’m injured!!”
Different neuron response differently
DRGs conditioning lesion paradigm
Namiko Abe, Valeria Cavalli.Current Opinion in Neurobiology (June 2008)
Lens injury promote RGCs regeneration
Injury signal pathway
Fang Sun, Zhigang He.Current Opinion in Neurobiology (August 2010)
NLS systems
NLS=nuclear localization signal
[importins] [RanGTP] [JIP]=JNK-interacting protein
MAPKs pathway MAKPKs mitogen-activated protein kinase family= (MAP) kinases
[JNK] c-Jun N-terminal kinase [Erk] extracellular signal-regulated kinase
Cargo that transport MAKPs vimentin: scaffolding protein for Erk 1 (steric hindrance) importin-activated Erk-vementin complex axonal vesicles: JNK
Local activation & retrograde
MAPKs pathway
Erk & JNK
ERK 2JNK
ERK2 & JNK
Main Cytokines signal pathway
IL-6 interleukin-6 LIF leukemia inhibitory factor CNTF cilliary neurotrophic factor
STAT3 signal pathway
Content 03Content 02Content 01socs3
Fang Sun, Zhigang He. Current Opinion in Neurobiology (August 2010)
mTOR signal pathway
Content 03Content 02socs3
Fang Sun, Zhigang He. Current Opinion in Neurobiology (August 2010)
Injury signal pathway
Fang Sun, Zhigang He.Current Opinion in Neurobiology (August 2010)
summary
Remaining question
Why ??
