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Hierarchie der Proteinstruktur

Sekundärstruktur: α-Helix

Ausrichtung lokaler Dipolmomente stabilisiert zusätzlich:

Bändermodell(Cartoon)

Page 4: Hierarchie der Proteinstruktur - schroderlab.org · Glycine Alanine Valine Leucine Isoleucine Proline Methionine Phenylalanine Tryptophan Serine Threonine Asparagine Glutamine Cysteine

Sekundärstruktur: β-Faltblatt

Bändermodell(Cartoon)

Page 5: Hierarchie der Proteinstruktur - schroderlab.org · Glycine Alanine Valine Leucine Isoleucine Proline Methionine Phenylalanine Tryptophan Serine Threonine Asparagine Glutamine Cysteine

Ramachandran-Plot

beta-Faltblatt

alpha-Helix

Lalpha

linkshändige Helix: Lalpha

Page 6: Hierarchie der Proteinstruktur - schroderlab.org · Glycine Alanine Valine Leucine Isoleucine Proline Methionine Phenylalanine Tryptophan Serine Threonine Asparagine Glutamine Cysteine

Ramachandran-Plot Statistik: Unterschiede zwischen Aminosäuren

Page 7: Hierarchie der Proteinstruktur - schroderlab.org · Glycine Alanine Valine Leucine Isoleucine Proline Methionine Phenylalanine Tryptophan Serine Threonine Asparagine Glutamine Cysteine

Tertiärstruktur (Folds): Beispiele

α/β Domain, Rossmann fold

PDB 1HDC

Immunoglobulin Domain,

PDB 1AQK

TIM BarrelPDB 1YPI Jellyroll

PDB 2BUK

Page 8: Hierarchie der Proteinstruktur - schroderlab.org · Glycine Alanine Valine Leucine Isoleucine Proline Methionine Phenylalanine Tryptophan Serine Threonine Asparagine Glutamine Cysteine

Quartärstruktur

Actin Filament

Page 9: Hierarchie der Proteinstruktur - schroderlab.org · Glycine Alanine Valine Leucine Isoleucine Proline Methionine Phenylalanine Tryptophan Serine Threonine Asparagine Glutamine Cysteine

from Stryer, Biochemistry

Page 10: Hierarchie der Proteinstruktur - schroderlab.org · Glycine Alanine Valine Leucine Isoleucine Proline Methionine Phenylalanine Tryptophan Serine Threonine Asparagine Glutamine Cysteine

from Stryer, Biochemistry

Page 11: Hierarchie der Proteinstruktur - schroderlab.org · Glycine Alanine Valine Leucine Isoleucine Proline Methionine Phenylalanine Tryptophan Serine Threonine Asparagine Glutamine Cysteine

Glycine

Alanine

Valine

Leucine

Isoleucine

Proline

Methionine

Phenylalanine

Tryptophan

Serine

Threonine

Asparagine

Glutamine

Cysteine

Tyrosine

Aspartic Acid

Glutamic Acid

Lysine

Arginine

Histidine

unpolar polar negativ geladen

positiv geladen

Page 14: Hierarchie der Proteinstruktur - schroderlab.org · Glycine Alanine Valine Leucine Isoleucine Proline Methionine Phenylalanine Tryptophan Serine Threonine Asparagine Glutamine Cysteine

Page 15: Hierarchie der Proteinstruktur - schroderlab.org · Glycine Alanine Valine Leucine Isoleucine Proline Methionine Phenylalanine Tryptophan Serine Threonine Asparagine Glutamine Cysteine

from Stryer, Biochemistry

pKa - Werte

Page 16: Hierarchie der Proteinstruktur - schroderlab.org · Glycine Alanine Valine Leucine Isoleucine Proline Methionine Phenylalanine Tryptophan Serine Threonine Asparagine Glutamine Cysteine

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