2006A1811 BL20XU

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Evaluation of Atherosclerotic Plaque Contents using Phase-contrastX-ray Computed Tomography

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Masakazu Shinohara, Masafumi Takeda, Naoto Sasaki, Tomoya Yamashita

Atsushi Momose*, Mitsuhiro Yokoyama

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Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine,

Kobe University Graduate School of Medicine

*Department of Advanced Materials Science, Graduate School of Frontier Science, The University of Tokyo

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To detect an unstable plaque that causes the acute coronary syndrome, a reliable method to assess the plaqueconfiguration noninvasively is required. Although the multislice computed tomography has been recentlydeveloped, it is still difficult to discriminate the plaque composition due to the small difference in theabsorption coefficient of biological objects. Phase-contrast x-ray imaging has great potential to investigate thestructures inside soft tissues because of its high sensitivity to light elements. To investigate the compositionsin atherosclerotic plaques of atherogenic-modified mice, phase-contrast x-ray CT was performed. Thesamples were also analyzed with the classical immunohistochemistry. The possibility that phase-contrastimage can reveal the compositions of atherosclerotic plaques was suggested.

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Abstract

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(1) Momose A. et al. Nature

Medicine 2, 473-475(1996)

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