ibd : storia naturale clinica tra vecchi e nuovi farmaci · fistula bl non-stricturing,...
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Simona PiergalliniU.O.S. Malattie Infiammatorie croniche
intestinali
U.O.C. Gastroenterologia ed Endoscopia Digestiva
Direttore Prof. G. Macarri
IBD : storia naturale clinica tra vecchi e nuovi farmaci
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MICI
CCCCDDDD
RCURCURCURCU
Geni di suscettibilità(NOD2/CARD15)
Fattori ambientaliAgenti infettiviFarmaciTabagismo, dieta
Sistema immunitarioFattori costituzionaliStruttura dell’epitelio
CI
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anti-Tnfalfa
Infliximab Etanercept Adalimumab Golimumab Certolizumab
Indicazioni terapeutiche
Artrite Reumatoide, Spondilite
Anchilosante, Artrite Psoriasica,
Psoriasimalattia Di Crohn,Colitre Ulcerosa
Colitre Ulcerosa e Crohn Pediatrico
Artrite Reumatoide,
Spondilite Anchilosante,
Artrite Psoriasica,Psoriasi
Artrite Idiopatica Giovanile
Artrite Reumatoide
SpondiliteAnchilosante,
Artrite Psoriasica,Psoriasi
malattia Di Crohn,
Artrite Reumatoide, Spondilite
Anchilosante, Artrite Psoriasica,Artrite Reumatoide
Disegno Molecole
Specificità TNFα TNFα/LT α TNFα TNFα
Posologia3-5mg/Kg e.v.
0,2,6 sett.poi ogni 50 mg sc ogni 7 gg8 sett.
80-40 o 160-8040 mg sc
ogni 7-15 giorni
200-10050-100 mg s.c.
ogni 28-30 giorni
TNFα
200 mg s.c. ogni 15 dì
Emivita 8-10 giorni circa 3 giorni circa 14 giorni circa 12 giorni 14 giorni
Colitre Ulcerosa
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OGGI…..OGGI…..OGGI…..OGGI…..
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DOMANI…..
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DOPO DOMANI…..
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….buon lavoro….