生物化學(ii) 脂肪酸合成

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(II)

1907 2 1930 1940 3 A (malonyl-CoA)

A

A A A

A

A A A A (acetyl CoA carboxylase) A (biotin) ATP

7

A (fatty acid synthase) A A A (acetyl-CoA transacylase) A (malonylCoA transacylase) (acyl carrier protein; ACP)

(fatty acid synthase)

(acyl carrier protein; ACP)

7

ACP 3- -ACP (3ketoacyl-CoA synthase) -SH 3- ACP(3-ketoacyl-ACP) CO2

7

4 6 3- ACP (3-ketoacyl-ACP-reductase) 3- -ACP- (3-hydroxyacylACP dehydrase) 2,3- ACP (2,3-transenoyl-ACP-drhydrase)

7

(palmitoyl thioesterase) 16 A A (CoASH) ACP

7

16 (4-7 ) ACP

9 9 12 15 A (fattyacyl-CoA desaturase) (Stearic acid; 18:0) (Oleic acid; 18:19)

(essential fatty acid)

(linoleate 18:29 12 ) (linolenate 18:3 9 12 15 ) (spinolipida)

- A -

A A A A I