il-6 ifnγ il-4 tgfβ
TRANSCRIPT
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Recirculação de linfócitos:
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Recirculação de linfócitos:
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Recirculação de linfócitos:
Ativação Celular
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Ativação de linfócitos T CD4 virgens:
- Três sinais são necessários:
Sinal 1: Reconhecimento do complexo peptídeo-MHC;
Sinal 2: Ligação com as moléculas coestimuladoras;
Sinal 3: Sinalização via citocinas.
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Ativação de linfócitos T CD4 virgens:
- Três sinais são necessários:
Sinal 1: Reconhecimento do complexo peptídeo-MHC;
Sinal 2: Ligação com as moléculas coestimuladoras;
Sinal 3: Sinalização via citocinas
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Classe 1
Classe 2
Receptores de citocinas:
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Classe 1
Classe 2
Receptores de citocinas:
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Sinalização via JAK/STAT:
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Sinalização via JAK/STAT:
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Diferenciação de células T helper:
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Diferenciação de células T helper:
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Diferenciação de células Th1:
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Diferenciação de células Th2:
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Diferenciação de células Th17:
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Diferenciação de células Treg:
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Função dos subtipos de T helper:
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Função dos subtipos de T helper:
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Diferenciação de células T helper:
- H3K27me3 (repressivo)
- H3K4me3 (permissivo)
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Doenças autoimunes relacionadas a defeitos na sinalização da via de JAK/STAT:
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Doenças autoimunes relacionadas a defeitos na sinalização da via de JAK/STAT:
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Células terminalmente
diferenciadas
Exceções!?
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- Células Th17 IL-10+
- Células RORγt+Foxp3+
- Células Th9- Células ROR γt+t-bet+
- Células reguladoras Foxp3-
Exceções!?
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Exceções!?
Diferenciação terminal X Flexibilidade e plasticidade celular
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Subtipos de células T CD4+ e a imunidade anti-tumoral:
Cânce
r
http://blogdasbi.blogspot.com
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Subtipos de células T CD4+ e a imunidade anti-tumoral:
Annu. Rev. Immunol. 2011. 29:235–71
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Subtipos de células T CD4+ e a imunidade anti-tumoral:
Cancer Metastasis Rev (2010) 29:309–316