Introduction to Structural Life Science Data Cloud

Akira R. KINJOInstitute for Protein Research, Osaka University

2015-09-13 (Sun)

本成果は、国立研究開発法人日本医療研究開発機構 創薬等ライフサイエンス研究支援基盤事業（創薬等支援技術基盤プラットフォーム事業）の支援により得られました。

Summary of homologs,structures, motifs, etc.

Compiling various information into one big table.

Human Structurome Today (64340 proteins)

~70% have some 3D information!

5210 (8%)

37994 (59%)

7192 (11%)

13944 (22%)

A. Determined B. 3D Homolog C. <12% ID D. >=12% ID

Determined 3D HomologA. B.

0

10

20

30

40

50

60

70

80 All

w/o ID

Mea

n co

vera

ge o

f seq

uenc

e

±35

±25

Mean coverage of sequence:60~70%

Determined 3D Homolog <12% ID >=12% IDA. B. C. D.

0

5

10

15

20

25

30

26

3.9

2.11.4F

ract

ion

of d

isea

se-r

elat

ed p

rote

ins

(%)

People love diseases (?)

“Structure � Disease” or “Disease � Structure”?

1357 (43%)

1484 (47%)

150 (5%)

190 (6%)

A. Determined B. 3D Homolog C. ID < 12% D. ID >= 12%

Out of 3181 disease-related (OMIM) proteins,90% have some structural information.

Disease-related ID < 12% Rod & Mam MembraneA. B. C. D.

0

50

100

150

200

250

300

350

400

340

150 147

111

Screening possible targets for structure determination

Remaining fruits

Avoid IDP Homologs may helpMembrane!

IDPs are not negligible.

Accession Name # diseases Diseases (e.g.)

P23942 Peripherin-2 6 CHOROIDAL DYSTROPHY, CENTRAL AREOLAR 2, etc

Q8WVP7 Limb region 1 protein homolog

4 SYNDACTYLY, TYPE IV, etc.

P49279 Natural resistance-associated macrophage protein 1

2 MYCOBACTERIUM TUBERCULOSIS, etc

Q8TDI8 Clarin-1 2 USHER SYNDROME, TYPE IIIA, etc.

Q9HCJ1 Progressive ankylosis protein homolog

2 CHONDROCALCINOSIS 2, etc.

Some examples of disease-related membrane proteins with no structure

● Grasping trends.

● Screening potential targets.

● Screening potential drugs.

● and much more.