kimia farmasi raafqi
TRANSCRIPT
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KISAH ORANG BUTA & GAJAH
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Pengertian Kimia Farmasi (KF)?
Ilmu pengetahuan yg mempelajari penemuan, pengembangan, identifikasi dan interpretasi cara kerja senyawa biologis aktif (obat) pada tingkat molekul. KF melibatkan studi identifikasi, sintesis produk, metabolisme obat dan senyawa yg berhubungan (IUPAC* 1974)
International Union of Pure and Applied Chemistry
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Sejarah Kimia Farmasi: Aspirin (1/4)Sejarah Kimia Farmasi: Aspirin (1/4)
MASA PRE-HISTORIKMesir (2000 SM)
MASA HISTORIKHippocrates (400 SM)
MASA MODERNAbad ke-19 hingga 21
Pohon willow (Salix)
Salisin
Mengunyah willow menurunkan
demam & redakan radang
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Sejarah Kimia Farmasi: Aspirin (2/4)Sejarah Kimia Farmasi: Aspirin (2/4)
Johann BuchnerUniv Munich-1828
Raffaele Piria Univ Sorbonne-1838
Charles F. Gerhardt Perancis-1853
Felix Hoffmann Bayer-1899
Salisin
Asam salisilat
As. asetil salisilat
Perkembangan Abad 19
Aspirin !
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Sejarah Kimia Farmasi: Aspirin (3/4)Sejarah Kimia Farmasi: Aspirin (3/4)
Gambaran 3 dimensi enzim siklooksigenase (COX) 1 dan 2 serta aspirin (abu-abu)
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Sejarah Kimia Farmasi: Aspirin (3/4)Sejarah Kimia Farmasi: Aspirin (3/4)
Gambaran sederhana enzim siklooksigenase (COX) 1 dan 2
Situs aktif aspirin
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http://www.om-pc.com/content/2/1/2/figure/F2?highres=y
Sejarah Kimia Farmasi: Aspirin (3/4)Sejarah Kimia Farmasi: Aspirin (3/4)
Diagram sederhana struktur COX-1 saat tidak ada aspirin (kiri) dan saat aspirin berkerja (kanan)
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Sejarah Kimia Farmasi: Aspirin (3/3)Sejarah Kimia Farmasi: Aspirin (3/3)
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Piper and Vane (1969)
http://journal.nzma.org.nz/journal/119-1242/2170/
Sejarah Kimia Farmasi: Aspirin (3/3)Sejarah Kimia Farmasi: Aspirin (3/3)
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Perkembangan Terbaru: QSAR & (Bio)Informatika
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Hubungan KF & Keilmuan Lain
MK Kimia Farmasi
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Jenis Obat
MK Kimia Farmasi
Artemisin
Quinin
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MK Kimia Farmasi
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Garis Besar Kerja Obat
MK Kimia Farmasi
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Gugus Fungsi Aktivitas Biologis Contoh obat
Sama Sama Gol. SulfonamidaAntibakteri: S.diazin, S.metazin, S.guanidin
Bervariasi Sama Analgesik antipiretik
metampiron, asetosal, asam mefenamat
Sama Bervariasi SulfonamidaDiuretik: asetazolamid &Antidiabetes: klorpropamidAntimalaria: sulfadoksin
Hubugan Struktur dan Aktivitas Obat
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MK Kimia Farmasi
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Referesi Pendukung
MK Kimia Farmasi
• Powerpoint, lecture note dan video youtube dengan kata kunci kimia medisinal, kimia farmasi,
• Kata kunci berbahasa Inggris: Medicinal chemistry, pharmaceutical chemistry, pharmaco chemistry, therapeutical chemistry
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MK Kimia Farmasi
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