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Kuliah NeoplasiaHarliansyah, Ph.D

2016

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General Model of Cell Kinetics

S

G1

G2 Mself-renewal

capacity

growth fraction

PROLIFERAIO!

APOPOSIS

"ifferentiation

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Molecular Basis of Neoplasia:

Proto-oncogene

Oncogene

  V - O n c

 O t  h e r

  H e r e d  i t  y

  R  a d  i a t

  i o n

 C  h e m  i c a

  l

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1

Chromosomal changes in the genome of cancer

cells: tip of the iceberg 

Terminal

Deletion

http://www.tokyo-med.ac.jp/genet/cai-e.htm

Ring

Chromosome

Robertsonian

Translocation

Deletion  Reciprocal

translocation

IsochromosomesInsertion Inversion

Duplication

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16

 Nucleotide changes in the genome of cancer

cells: unseen site of the iceberg  

NucleotideDeletions

NucleotideInsertions

NucleotideSubstitutions

http://www.tokyo-med.ac.jp/genet/cai-e.h

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Type of DNA Mutation

#olor Atlas of Genetics$ 2n" E"$ Passarge% E$ hie&e$ St'ttgart% Ger&any 2((1

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Molecular !asis for ris" factors

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2#

  )MOR S)PPRESSOR GE!ES

Disorders in which gene is affected 

Gene (locus) Function Familial Sporadic  

*## +1,. cell s'rface 'n/nown colorectal

  interactions cancer  

 01 +11p. transcription 0il&s t'&or l'ng cancer  

 R1 +13. transcription retinolasto&a s&all-cell l'ng

  carcino&a

 p43 +15p. transcription Li-Fra'&eni reast% colon%  syn"ro&e 6 l'ng cancer  

7R#A1+15. transcriptional reast cancer reast8o9arian

t'&ors

7R#A2 +13. reg'lator8*!A repair 

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26

arly "rain Tumor 

#$strocytoma %tage II&

$dvance "rain Tumor 

'lioblastoma (ulti)orm #%tage I*&

D+$ ,oss in cancer cells: beyond coincidence ...

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2$

p53

locus

Chromosomal loss:

Mostly, it is a sign

for the loss of atumor suppressor

gene

P!"

locus

C#$"%

locus

R&'

locus

(((

locus

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Tissue Cell #

=

Cell Proliferation Cell Death__

Oncogenes _Tumor

Suppressor

Genes

Pro –

ApoptoticFactors

_Anti –

ApoptoticFactors