lab. for applied physiology university of tokushima
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Lab. for Applied Physiology University of Tokushima. Application of NIRS to Measure Muscle Metabolism and Vessel Function. H Miura Ph.D. First encounter. ’98 ~ ’99 at BC’s Lab. 1) Brain function 2) Cancer detection 3) Muscle metabolism 4) Cesarean detection 5) Developing device etc. - PowerPoint PPT PresentationTRANSCRIPT
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Lab. for Applied PhysiologyUniversity of Tokushima
Application of NIRS to Measure Muscle Metabolism and Vessel
Function
H Miura Ph.D.
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First encounter
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’98 ~ ’99 at BC’s Lab.
1) Brain function2) Cancer detection3) Muscle metabolism4) Cesarean detection5) Developing device etc
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Diagram for functional NIR imager
AmplifierAmplifier
Sensor ● light source■ photodetector
A/D BoardA/D Board
LampController
LampController
Miura et al. Jpn J Phys Fitness Sports Med 2000
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COGNOSCOPE NIM INCORPORATED
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Measurement of muscle metabolism by functional NIR imaging device
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0.2
0.0
-0.2
Exercise deoxygenation
oxygenation
0.2
0.0
-0.2
Recovery deoxygenation
oxygenation
Right Leg
0.2
0.0
-0.2
Rest deoxygenation
oxygenation
(o.d.)
Oxygen saturation during standing plantar flexion in gastrocnemius muscle
Miura et al. Jpn J Phys Fitness Sports Med 2000
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0.2
0.0
-0.2
Exercise increase
decrease
0.2
0.0
-0.2
Recovery increase
decrease
Right Leg
0.2
0.0
-0.2
Rest increase
decrease
(o.d.)
Blood volume during standing plantar flexion in gastrocnemius muscle
Miura et al. Jpn J Phys Fitness Sports Med 2000
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What’s next?
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Exercise Recovery
Right Leg
Miura et al. Jpn J Physiol 2001
Rest
0.2
0.1
0.0
-0.1
-0.2
deoxygenation
oxygenation
(o.d.)
Oxygen saturation during standing plantar flexion in medial head of gastrocnemius muscle
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Exercise Recovery
Right Leg
Rest
0.2
0.1
0.0
-0.1
-0.2
increase
decrease
(o.d.)
Miura et al. Jpn J Physiol 2001
Blood volume during standing plantar flexion in medial head of gastrocnemius muscle
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What’s next?
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oxy-
Hb
(μm
ol)
●: PVD ● : Healthy
(sec)occlusion recovery
-30
-20
-10
0
10
20
30
0 100 200 300 400 500 600
Miura H, Okumura N Adv Exp Med Biol 2010
Change of oxygeation during thigh occlusion test
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Rec
over
y tim
e (s
ec)
healthy 1 2 3 4 5 60
20
40
60
80
100
The larger number indicates the more severe of PVD
PVD
Recovery time in PVD patients and healthy subjects
Miura et al. Spectroscopy 2002
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0
20
40
60
80
100
Rec
over
y tim
e (s
ec)
healthy 1 2 3 4 5 6
#5’ and #6’ indicate the data after taking medication
5’ 6’PVD
Recovery time in PVD patients and healthy subjects
Miura et al. Spectroscopy 2002
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oxy-
Hb
(o.d
.)
■: Hypertensive group ■ : Healthy group
(sec)
-0.03
-0.02
-0.01
0.00
0.01
0.02
0.03
0 20 40 60 80 100 120 140 Rest Cold Pressor Test
Miura et al. JJCA 2011
Change of oxy-Hb during cold pressor test
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Prospect of NIRS
1) Owing to Chance’s great achievements, improvements in NIRS have matured this technique to be applicable for a wide range of applications2) NIRS is still prospective technology and in the future this kind of tool might play a crucial role in diagnosing, treating some diseases, or defining therapy process
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My BC’s memory
Toward research, Britton Chance was strict and showed no willingness to compromiseBritton Chance will be greatly missed as a great scientist in exercise physiology and clinical medicine
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With deepest regret, Hajime Miura
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