1- (Quality Control)2- (Calibration)3- (Normal Range)4- (Diagnostic Accuracy Studies)

( ) :

1- : Randox ..._ _ _ _ 2- Pooled Serum:_ _ _ 3- (Average of Normal, Normal Range):_ _ ( ) 4- (Patient Mean):_ _ ( )

_

_ ( Inaccuracy) %Bias :

%Bias = [(test value control value) / control value] * 100

_ Bias ( ) ( )

_

_

_ :_ ( )_

:1- _ _ %CV

2- Paired T-test:_ _ (Paired) (Case ) _ P value 0.05 _ Cell Counter

3- Control Chart (Levey-Jenning):_ (Random or Systematic)

_

Total Error = |%Bias| + %CV

_ :1- :10% 5% 2- : 3- : ) ) :

{[(Normal Range) / 4] / Mean of Normal Range} * 100

: FBS 60 110Normal Range = 110-60 = 50Mean = (110+60)/2 = 85{[50/4]/85} * 100 = 14.7%

: Medcalc:Control Mean = 13%Bias = [(13 13.36) / 13] * 100 = - 4.61%%CV = 8.08%Total Error = 4.61 + 8.08 = 12.69%

Cell Counter Paired T-test Medcalc:

Cell Counter Paired T-test Medcalc:

Control Chart Medcalc

Control Chart Medcalc

Correction Factor = 1 - Bias

)

)

) : MCV

. .

1- Hct ( )2- RBC1- RBC = Hct * (116/1000) 2- RBC (Mil/l) = [Hct (%) / MCV (fl)] * 10 MCV3- Using Hemocytometer chambers3- Hct 6-2 4- Hb Hct = Hb * 35- WBC PLT

:1- 3% 97%2- Mean 2SD

_ :1- 2- Cutoff Point

_ Gold Standard (GS)

_ GS:1- 2-

1- (Sensitivity):_ _ Sensitivity = TP / (TP + FN)2- (Specificity):_ _ Specificity = TN / (TN + FP)3- (Positive Predictive Value, PPV):_ PPV = TP / (TP + FP)3- (Negative Predictive Value, NPV):_ NPV = TN / (TN + FN)

_ :1: Perfect test> 0.9: High Accuracy0.7 0.9: Moderate Accuracy0.5 0.7: Low Accuracy< 0.5: not Accurate

_ (Screening):_ _ FP

_ (Diagnosis):_ _ FN