laboratory investigation advance online publication 8 january 2007; doi:10.1038/labinvest.3700509 no...

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Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509 No Wnt signaling

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Page 1: Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509 No Wnt signaling

Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509

No Wnt signaling

Page 2: Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509 No Wnt signaling

Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509

ß-catenin recruitment and phosphorylation

Page 3: Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509 No Wnt signaling

Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509

ß-Trcp binding and ß-catenin degradation

Page 4: Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509 No Wnt signaling

Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509

Downstream gene expression inhibited

Page 5: Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509 No Wnt signaling

Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509

Wnt signaling

Page 6: Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509 No Wnt signaling

Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509

Activation of Disheveled and inhibition of ß-catenin degradation

Page 7: Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509 No Wnt signaling

Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509

Formation of LEF/TCF transcriptional complex

Page 8: Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509 No Wnt signaling

Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509

Downstream gene expression activated

Page 9: Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509 No Wnt signaling

Laboratory Investigation advance online publication 8 January 2007; doi:10.1038/labinvest.3700509

Crosstalk between Wnts and other pathways