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Ministry for Economics, Labour and Transport of Niedersachsen
Life Sciences
in Niedersachsen
At the Heart of Europe
Biotechnology, Life Sciences
• Niedersachsen is one of the largest bioregions
in Germany: more than 5,000 scientists,
21 universities and colleges and 34
non-academic research institutions
• Strength in pharmaceutical biotechnology,
infection, neurobiology, stem cell biology,
medical engineering, veterinary medicine and
plant biotechnology
• about 160 Life Science companies and 50 medical technology companies
Biotechnology, Life Sciences
BIOTECHNICA Fair 2017
• 16th – 18th of May 2017 (biennial) BIOTECHNICA and LABVOLUTION
• more than 10,000 visitors in 2015
• Life Sciences, Biotechnology and Lab technologies (Smart lab)
• Marketplaces for BioServices, Innovation in Food, Industrial Biotechnology and
Personalized Medicine
• 11th BIOTECHNICA Award
Relevant Networks
• BioRegioN, Network for Healthcare and Life Sciences
Contact: Dr. Maike Rochon
• eHealth Niedersachsen
Contact Dr. Maik Plischke
• Nieke, Agri Food State Initiative
Contact: Dipl.-Ing. agr. Doris Schröder
• 3N Competence Center for Renewable Raw Materials
Contact: Dr. Marie-Luise Rottmann-Meyer
• COALA Competence Center of Applied Agricultural Engineering
Contact: Prof. Ruckelshausen
Clusters of excellence (I)
• Rebirth (Form Regenerative Biology to Reconstructive Therapy)
- focus on blood, liver, heart and lung
- focus on stem cell biology and reprogramming
• Hearing4all
Research: Improving Diagnostics
Better Hearing Devices
Assistive Technology
Promotion of Young Researchers
Translational Research Center (HörtechgGmbH)
Clusters of excellence (II)
• Nanoscale Microscopy and Molecular Physiology of the Brain and
DFG Research Center Molecular Physiology of the Brain (CMPB)
Advanced Microscopy
A1 Microscopy at the Nanometer Range / Cluster of Excellence
A2 Quantitative Molecular Microscopy
Neurodevelopmental Disorders
B1 From Neurogenesis to Synaptogenesis
B2 From Synaptopathies to System Dysfunction
Neurodegenerative Diseases
C1 From Network Dysfuntion to Psychiatric Diseases
C2 Aggregation Disorders - Parkinson's Disease
Technology Platforms
D1 Proteomics
D2 Viral Vectors
D3 Primate Models
D4 Electron Microscopy
Infection
• Hannover Medical School
- transplantation (immunology), gene & cell therapy, hepatology
- more than 3000 students, 80 Mio in funds (2008)
• Helmholtz Centre for Infection Research, Braunschweig
- investigation of medically relevant pathogens (Pseudomonas,
Listeria)
- 700 staff from 40 countries, 45 Mio budget from federal
government
• TWINCORE, Hannover Braunschweig Cooperation
- Centre for Experimental and Clinical Infection Research
- screening of biological compound libraries
- in vivo propagation of hepatitis C virus
- preclinical testing for humanized mouse models
Picture: HZI Staphylococcusaureus
Infection
• Fraunhofer Institute for Toxicology and Experimental Medicine
- focus on respiratory tract as target organ
- preclinical testing toxicology and pharmacology
- clinical studies phase I – IV for the registration of pharmaceuticals
(allergy, COPD, asthma)
• German Collection of Microorganisms and Cell Cultures
- the most comprehensive Biological Resource Centre in Europe
- more than 18000 microorganism, 1200 plant viruses,
600 human and animal cell lines, 770 plant cell cultures
- independent non-profit organisation
• Headquarter of the newly founded German Center for Infection Research (DZIF)
HZI, Streptococci on
mouse collagen
Infection
27 partners will form a tight research network to bundle Germany’s health research with the German Centre for Infection Research. Coordination and administration will be located at the Helmholtz Centre for InfectionResearch (HZI).
Neurobiology
• European Neuroscience Institute
- functioning and diseases of nervous system
- foster treatment of Schizophrenia, Parkinson, Alzheimer
• Bernstein Centre for Computational Neuroscience
- analyse function of the brain
- combine experiments with mathematical models and computer models
• German Primate Centre
- biological and biomedical research on and with primates
- host 1500 primates, S2 and S3 safety labs
- Primate biology, neuroscience (Parkinson, Multiple sclerosis) and infection (HIV)
• International Neuroscience Institute
- high end clinical treatment of neurological diseases
Stem cell and medical engineering
• Leibniz University
- research funds 2010: 80 Mio
- more than 22.000 students 2011/2012
- enabling technologies: biophotonic,
- nanoengineering, cell manipulation, tissue engin.
• Rebirth (Form Regenerative Biology to Reconstructive Therapy)
- focus on blood, liver, heart and lung
- focus on stem cell biology and reprogramming
• Hearing technology: Universities in Oldenburg and Hannover (Research Center Vianna)
• Otto Bock Healthcare GmbH, world market leader in orthopaedics
• NIFE (translation center of implant research, Tiho, LZH, Leibniz University H)
Veterinary medicine
• University of Veterinary Medicine
- founded 1778
- 6 clinics, 18 institutes, 5 centres
- about 2000 students enrolled
- areas of research: infections, clinical research,
neurosciences, animal health and food quality
- future: 18 Mio € funding zoonoses center
- host-pathogen interaction: Campylobacter,
Salmonella
• Federal Research Centre of Animal Health (Institute of Animal Nutrition, Institute of
Animal Welfare and Animal Husbandry, Institute of Farm Animal Genetics)
• European vaccine development research center
of Boehringer Ingelheim vetmedica GmbH
Veterinary medicine
• Lohmann Animal Health
- leading manufacturer and supplier of poultry biologicals
- offer modified live and inactivated vaccines
- address infectious bronchitis, Newcastle disease, REO and infectious bursal disease
- offer Feed Additives: Acid Blends, Amino Acids, Enzymes, Probiotics and Trace Elements
- GMP
• IVD GmbH
- IVD performs serological and molecular biology-based diagnostics of infectious
diseases in pigs, ruminants, horses, dogs, cats and exotic animals (reptiles and
amphibians).
• Fassisi GmbH
- develop on-sites diagnostics and for laboratory applications in small and large animal
practice or clinic.
Veterinary medicine
• WDT Industrial and Provident Society of German Veterinary Surgeons
- commercial cooperative of veterinarians since 140 years
- shareholders 6300 veterinarians
- sera, bacterial and fungal vaccines, specific diagnostic products e.g. tuberculins
- the only GMP certified facility for the production of tetanus serum in Europe
• Intervet
- 120 employees
- animal vaccines for EU
- products for cattle, horses, swine, sheep, dogs and cats
- 5 production units
Translation Alliance in Niedersachsen - TRAIN
Helmholtz-Centre for
Infection Research (HZI)
University of Veterinary
Medicine, Hannover (TiHO)
Zoonoses, Animal Models,
Veterinary Medicine
Infection mechanism, Pharmaceutical Sciences, Vaccines, Natural
Products
Synthesis of new chemical entities and
natural products
Chemistry-Mathematics-Biology Biology-Medical Research From Bench to Bedside
Translational
Centre
Twincore
Drug
Discovery
Centre
BRICS
Systems
Biology
Zoonosis-
Centre
Clinical Trials Centre
CTC
TRANSLATION
Medical School
Hannover (MHH)
Technical University
Braunschweig (TU BS)Frauenhofer-Institute for Toxikology
and Experimental Medicine (ITEM)
Systems Biology,
Bioinformatics, MicrobiologyInfectious Diseases, Regenerative
Medicine, Tumor Bank, Immunology
Drug Research, Toxicology, Pharmacology,
GMP-Production
Leibniz University
Hannover (LUH)
Plant Biotechnology
• Federal Research Centre for Cultivated Plants
- focus on Protecting Plants, Plant health, Plant
Protection Research, Reduction of Plant
Protection Products (Julius Kühn Institute)
• Federal Research Institutes for Rural Areas,
Forestry and Fisheries (von Thünen Institute)
- Economics of agriculture, forestry, lumber, food
and fish production
- material use of renewable resources, climate
- Biodiversity and organic farming
• Seed Production companies (sugarbeets, corn, crop, rapeseed) for example KWS SAAT AG
(# 4 in the world) (picture: KWS, in vitro sugar beets in culture)
Bioeconomy in Niedersachsen
• Weser Ems region
- Hot spot of Agrar economy in Niedersachsen (279 companies, 43%)
- Knowledge transfer: Networks for Bioeconomy like Nieke (network for agrarindustry)
and 3N (Renewable raw materials), Competence Center COALA (Competence
Center of Applied Agricultural Engineering), and DIL, German Institute for Food
Technology
- Projects: Enhance use of raw materials as chemical feed stock, managment and
quality assurance of dung/farmyard manure, Nutrition of the Future (Nutraceuticals,
functional food)
• DIL, German Institute for Food Technology
Contact Dr. Heinz
Bioenergy in Niedersachsen
• 1546 biogas plants are located in Niedersachsen
(end of 2014)
• Direct jobs: 1944
• Indirect jobs 4000 (plant construction, service and
maintenance, cultivation of energy crops, research and
education, lawyers, tax advicer)
• Installed electric power 885 MW (end of 2014)
• Plants produce about 25% of the renewable electricity in Niedersachsen
Start-up Centres
Jade Innovations-Zentrum, Wilhelmshaven
Medical Park Hannover GmbH, Hannover
SciencePark, Göttingen
• Lab and office space ready for immediate use
• Conference and meeting rooms available
• Access to Life Science networks, universities, institutes (MPIs)
Ministry of Economics, Labour and Transport of Niedersachsen
Friedrichswall 1
D-30159 Hannover
Phone: 0049 511 120 5585
www.nds.de
In Russia
Anna Urumyan
1. Kasatschiy per. 7
119017 Moskau, RF
Tel.: +7 495 730 40 43
Fax: +7 495 730 40 44
Bioinformatics SME in Niedersachsen
• Original world‘s biggest biological
databases: TRANSFAC®,
TRANSPATH (30 years of development)
• Unique aproach for automatic discovery of
drug targets and biomarkers
• 1 mln. lines of code of geneXplain software
platform covering all bioinformatics fields.
• >1200 world-wide users including Big
Pharmas, red and green biotech and
academia.
• 12 employees in Germany and India and
cooperation with Russian software
development company (50 employees).
Drug discovery – like the old Gold Rush
Tools
But - old approach in drug discovery fails
Trovafloxacin - antibiotic
6 death out of 3 millions
Withdrawn from market due to risk of idiosyncratic hepatotoxicity in 2001.
Drug discovery should become a technology
Disease
Patient
Therapy
Bucket dredging
Novel approach – systems medicine!
Systems approaches will transform the way drugs are developed … to target multiple components of networks
and pathways perturbed in diseases.
They will enable medicine to become predictive,personalized, preventive and participatory
Systems medicine: the future ofmedical genomics and healthcare
Charles Auffray1*, Zhu Chen2
and Leroy Hood3
Genome Med 2009, 1:2
geneXplain platform – a tool for drug discovery
using systems medicine approach
geneXplain technology
Genome,TranscriptomeProteome,Metabolome
DNA methylation
Patient,Disease
Drug
NetworksTargets
Success story – new anticancer lead compound
Apoptosis
?RITA – p53 activation compoundFind a new compoundcomplementaryto RITA.
Cancer
geneXplain identified targets (key nodes) in the
network of cancer cell survival mechanism
PI3-kinase subunit
We found a new compound - inhibitor of the
drug targets
… …
ChemNavigator Library
24 million compounds
PASS programfrom Russianpartners
This novel anti-cancer compound was
validated in-vitro and in mouse xenografts.
Vehicle
Compound N23 10mg/kg
Compound N23 50mg/kg
We found TGF-beta1 as a potential off-target
effect of TVX. Promoter of TGFb gene contains SNPs
Trovafloxacin (TVX)
TGF-beta1
SMADsite
A G
STATsite
C T
The carrier of these two mutations is vulnerable !!!
Don’t give TVXto this patient !!
Market volume and trends
Trends: Constant growth• of outsourcing of R&D services in
Pharma companies• of Bioinformatics services in
world-wide drug discovery oursourcing
Volume of bioinformatics service market
Total volume of drug discovery oursourcing: - Search for novel targets. - Sequencing and analysis of “omics” data- Identification of drug mechanisms of action.
Сегмент биологических услуг занимает 26%
0 1 2 3 4 5 6
Russia
India
China
Japan
Italy
Spain
France
Germany
UK
Canada
USA
Market geographical segments
(bln. USD)
2010 г. $3,1 bln.
2011 г. $3,8 bln.
2012 г. $4,9 bln.
2013 г. $6,1 bln.
2014 г. 7,5 bln.
2015 г. $9,5 bln.
2011 year - $9,34 bln2021 year - $31,14 bln
Refernces: 1) Visiongain: Drug discovery outsourcing world market 2011-2021; 2) RNCOS: Bioinformatics market outlook to 2015
EU and German grants