lunatic fringe hes7 pi hes7 1 achilles lunatic fringe 2020 1 8 1 9 … · 2020. 11. 6. · pi hes7...
TRANSCRIPT
iCeMS 1 / 5
Hes7 1
Lunatic fringe Hes7
PI
(
)
Hes7
Hes7
Hes7
1
Hes7
Achilles
Hes7
Lunatic fringe
2020 1 8 1 9 3
Nature
iCeMS 2 / 5
1.
(Presomitic mesoderm: PSM)
2 3 5
Hes7 ( ) PSM
iCeMS 3 / 5
Hes7
PSM
PSM Hes7
Notch
Notch Lunatic fringe Lfng
Hes7
Lfng Hes7
Hes7 Lfng
Hes7
2.
(1) Hes7
PSM
Hes7
Hes7
20
Hes7
Venus Achilles
PSM Achilles Hes7
Hes7
iCeMS 4 / 5
(2) Lfng
Lfng PSM Hes7
Lfng PSM
Hes7
Notch
Lfng
(3) Lfng
Lfng
Lfng PSM 1:20
Lfng 1/8
Lfng
20:1 Lfng
Lfng
Hes7
Notch /
Lfng Notch
Lfng Notch
Dll1
Lfng
Lfng Notch
Hes7
(4)
Lfng
ES PSM
Wnt
KY02111 Lfng
Hes7
iCeMS 5 / 5
Lfng PSM Notch
3.
Lfng
4.
1
5.
JST CREST
Brain/MINDS
6.
Coupling delay controls synchronized oscillation in the segmentation clock
( )
Kumiko Yoshioka-Kobayashi, Marina Matsumiya, Yusuke Niino, Akihiro Isomura, Hiroshi
Kori, Atsushi Miyawaki, and Ryoichiro Kageyama
Nature DOI: 10.1038/s41586-019-1882-z