modelos animais de enfermidades humans … · population ranges from 12% in people over 75 years of...

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Día da Ciencia en Galego MODELOS ANIMAIS DE ENFERMIDADES HUMANS (GI-1845) Envellecemento cerebral no can: un modelo da Enfermidade de Alzheimer

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Page 1: MODELOS ANIMAIS DE ENFERMIDADES HUMANS … · population ranges from 12% in people over 75 years of age to as high as 50% in people older ... V [Dtalrnente en las anlmalanoae facultaa

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MODELOS ANIMAIS DE ENFERMIDADES HUMANS

(GI-1845)

Envellecemento cerebral no can: un modelo da

Enfermidade de Alzheimer

Page 2: MODELOS ANIMAIS DE ENFERMIDADES HUMANS … · population ranges from 12% in people over 75 years of age to as high as 50% in people older ... V [Dtalrnente en las anlmalanoae facultaa
Page 3: MODELOS ANIMAIS DE ENFERMIDADES HUMANS … · population ranges from 12% in people over 75 years of age to as high as 50% in people older ... V [Dtalrnente en las anlmalanoae facultaa

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o CANS E ENFERMIDADE DE

ALZHEIMER

Page 4: MODELOS ANIMAIS DE ENFERMIDADES HUMANS … · population ranges from 12% in people over 75 years of age to as high as 50% in people older ... V [Dtalrnente en las anlmalanoae facultaa

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o SIMILITUDES

CLINICAS: • Trastornos na

orientación. • Trastornos na

interacción social. • Trastornos do ciclo

sono-vixilia. • Trastornos na

conduta de eliminación.

PATOLOXICAS: • Pérdida de neuronas. • Depósitos do péptido β-amiloide.

• Ovillos neurofibrilares constituidos por cúmulos intracelulares de proteína TAU.

Page 5: MODELOS ANIMAIS DE ENFERMIDADES HUMANS … · population ranges from 12% in people over 75 years of age to as high as 50% in people older ... V [Dtalrnente en las anlmalanoae facultaa

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o NOSA CONTRIBUCIÓN

Page 6: MODELOS ANIMAIS DE ENFERMIDADES HUMANS … · population ranges from 12% in people over 75 years of age to as high as 50% in people older ... V [Dtalrnente en las anlmalanoae facultaa

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Page 7: MODELOS ANIMAIS DE ENFERMIDADES HUMANS … · population ranges from 12% in people over 75 years of age to as high as 50% in people older ... V [Dtalrnente en las anlmalanoae facultaa

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Page 8: MODELOS ANIMAIS DE ENFERMIDADES HUMANS … · population ranges from 12% in people over 75 years of age to as high as 50% in people older ... V [Dtalrnente en las anlmalanoae facultaa

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Representative pictures of nucleus basalis magnocellularis p75NTR in a young (A), aged-NCI (B) and aged-CI (C) dogs. Young dogs were characterized by an intense staining of p75NTR neurons. The number of p75NTR neurons in the

basal forebrain was significantly higher in aged-NCI than in aged-CI dogs (B, C).

Page 9: MODELOS ANIMAIS DE ENFERMIDADES HUMANS … · population ranges from 12% in people over 75 years of age to as high as 50% in people older ... V [Dtalrnente en las anlmalanoae facultaa

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o NOSA CONTRIBUCIÓN

Page 10: MODELOS ANIMAIS DE ENFERMIDADES HUMANS … · population ranges from 12% in people over 75 years of age to as high as 50% in people older ... V [Dtalrnente en las anlmalanoae facultaa

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Page 11: MODELOS ANIMAIS DE ENFERMIDADES HUMANS … · population ranges from 12% in people over 75 years of age to as high as 50% in people older ... V [Dtalrnente en las anlmalanoae facultaa
Page 12: MODELOS ANIMAIS DE ENFERMIDADES HUMANS … · population ranges from 12% in people over 75 years of age to as high as 50% in people older ... V [Dtalrnente en las anlmalanoae facultaa

O FUTURO…

Page 13: MODELOS ANIMAIS DE ENFERMIDADES HUMANS … · population ranges from 12% in people over 75 years of age to as high as 50% in people older ... V [Dtalrnente en las anlmalanoae facultaa

GRAZAS