mucosal immunity of the intestine: homeostasis and inflammation · 2018. 1. 17. · gut mucosal...
TRANSCRIPT
MAdCAM-1
TACI
IL-12 Rβ2
CRTAM
IL-1RIA2BAR
CD90
IL-17 RB
IL-17 RB
IL-23 R
IL-23 RTSLP R
TSLP R
TSLP R
IL-1RIIL-7 Rα/CD127
CD117/c-Kit
CX3CR1CD14
Siglec-3/CD33FCAR/CD89
IL-2 Rβ
TSLP R
CXCR6
CCR7
CCR6
CCR6
CCR6
pIgA
CCR6
CCR6
IL-1RI
gp130
Common γ chain
IL-12 Rβ1
IL-21 R
IL-6 Rα
IL-23R
CRTAM
TGF-β RI
IGSF4A
IL-1 RAcP
Integrin α4β7
Integrin α4β7
Integrin αE/CD103
Integrin αE/CD103Integrin αE/CD103
Integrin αE/CD103Integrin αE/CD103
Integrin αM/CD11bIntegrin αM/CD11b
CCR7CCR7
Integrin αE/CD103
Integrin αE/CD103Integrin αE/CD103
TLR 2,4,5,7/8,10 sIgA ImmuneComplexes
CLEC9a, DCIR, DC-SIGN, SIGNR1
CCR7
TLR2, TLR4, TLR5TLR2, TLR4, TLR5
CX3CR1
CX3CR1
CX3CR1
CCR10
CXCR5GITR
KLRG1
CD25/IL-2 Rα
CXCR5
CXCR5
ICOS LigandCD84
NTB-A
B7-H1
B7-H2PD-L2
CD40
CD40
CXCL13/BLC/BCA-1IL-10TGF-β
IL-9IL-10IL-35TGF-β
IL-6IL-9IL-17AIL-17F
IL-21IL-22IL-26TNF-α
iNOSTNF-α
IL-6IL-12IL-23Osteopontin
EN-RAGEIL-12IL-23
IL-6IL-7IL-17ERetinoic AcidSecretogranin VTGF-βTSLP
Apolipoprotein A1APRILBAFFCCL9/MIP-1γCCL20/MIP-3αClusterinCXCL7/NAP-2CXCL8/IL-8
Epithelium-Derived Homeostatic Factors
APRILBAFFCCL2/MCP-1CCL5/RANTESCCL20/MIP-3αClusterinCXCL8/IL-8α-Defensins
FABP5IL-15Reg3ARetinoic AcidSecretogranin VSPLA2/PLA2G2ATGF-βTSLP
TRAILCCL5/RANTESCCL11/EotaxinIL-4IL-5IL-13
IL-1IL-6Nitric OxideROSTNF-α
IFN-γPerforinTNF-α
IFN-γPerforinTNF-α
IFN-γIL-17IL-22
GranzymesIFN-γPerforinTNF-α
GranzymesIFN-γPerforinTNF-α
APRILBAFFTGF-β
CXCL13/BLC/BCA-1IL-5IL-6Retinoic Acid
CCL5/RANTESCCL11/EotaxinGM-CSFIL-4Leukotriene C4PAFProtectin D1Resolvin E3
CCL5/RANTESCCL11/EotaxinGM-CSFIL-4Leukotriene C4PAFProtectin D1Resolvin E3
IL-9IL-10IL-21
IL-10IL-13IL-22
IL-17AIL-22
IL-10IL-35TGF-β
GM-CSFIFN-γIL-17AIL-22
IFN-γIL-17IL-22
AmphiregulinIL-4IL-5IL-9IL-13
Granzyme B
IL-10Retinoic AcidTGF-β
BTLA
CD28
CD40
CTLA-4
ICOS
PD-1
CD84, NTB-A, SLAM
CD21
CXCR4
CXCR3
CCR10
CCR7
CD90
CD117/c-kit
IL-1RI
IL-23 R
CD25/IL-2 RαNCAM-1/CD56
IL-7 Rα/CD127
IL-7 Rα/CD127PSGL-1
FCAR/CD89
FCAR/CD89
CCR2
CXCR2
CXCR1
P-Selectin
TfRTfR
ILC1ILC1
CytotoxicNK Cell
CytotoxicNK Cell
CD103+
Dendritic CellCD103+
Dendritic Cell
CD103+
Dendritic CellCD103+
Dendritic Cell
ILC3ILC3
Treg(Suppressed)
Treg(Suppressed)
ILC2(Suppressed)
ILC2(Suppressed)
PlasmaCell
PlasmaCell
PlasmablastPlasmablast
Follicular T Helper
Cell
Follicular T Helper
CellB CellB Cell
FollicularT Regulatory
Cell
FollicularT Regulatory
Cell
Th17Th17
CX3CR1+
DendriticCell
CX3CR1+
DendriticCell
MacrophageMacrophage
PathogenicBacteria
PathogenicBacteria
Lumen of Small IntestineLumen of Small Intestine
HomeostasisHomeostasis InflammationInflammation
BasementMembraneBasementMembrane
TregTreg
Th22Th22
Th9Th9LTiLTi
Plasma CellPlasma Cell
Paneth CellsPaneth Cells
Goblet CellGoblet Cell
Goblet CellGoblet Cell Goblet CellGoblet Cell
MacrophageMacrophage
EnterocytesEnterocytesMucous LayerMucous Layer
M CellM Cell
M CellM Cell
CD103+
DendriticCell
CD103+
DendriticCell
CX3CR1+
DendriticCell
CX3CR1+
DendriticCell
CX3CR1+
DendriticCell
CX3CR1+
DendriticCell
FollicularDendritic
Cell
FollicularDendritic
Cell Peyer’s PatchPeyer’s Patch
SubmucosaSubmucosaMuscularis ExternaMuscularis Externa
EosinophilEosinophil
MonocyteMonocyte
BregBreg
ILC2ILC2
TrmTrm
ILC3ILC3
ImmunoregulatoryNK Cell
ImmunoregulatoryNK Cell
EosinophilEosinophil
CD103+
Dendritic CellCD103+
Dendritic Cell
MonocyteMonocyte
NeutrophilNeutrophil
NeutrophilsNeutrophils
M CellM Cell
CX3CR1+
Dendritic CellCX3CR1+
Dendritic Cell
TLR4TLR4
TLR4TLR4
TLR4TLR4 TLR4TLR4
CD163
sIgA
sIgA
sIgA
sIgA
sIgA
CD68
Fcγ RIII/CD16
CX3CR1CX3CR1
CX3CR1
Connexin 43Connexin 43
DC-SIGNDC-SIGN
SIRPα
CD47
NKp30, 44, 46NKp30, 44, 46CD94
DNAM1
NKG2D
CX3CR1
CXCR1
FCAR/CD89
MAdCAM-1
CCR2,5,7
IL-12 Rβ1
CD19
MAdCAM-1
BCMA
TNF RCCR9
CCR10
IgA
Integrin α4β7
TACIBCMA
BAFF R
Integrin α4β1
Integrin αLβ2
Lymphotoxin α1β2
ICAM-1
VCAM-1TLR5
Fcγ RII/CD32
Fcγ RIII/CD16
BTLA
CD28
CD35
CD35 CD21
CD21
TLR4
TLR4
TLR2
CD36 MAdCAM-1
CTLA-4ICOS
PD-1
Dectin-1Dectin-1
DC-SIGNDC-SIGN
NKG2DNKG2D
CD69CD69
Integrin α4β7Integrin α4β7
CX3CR1CX3CR1
Connexin 43Connexin 43
Connexin 43Connexin 43
Connexin 43Connexin 43
AntigenAntigen
CCR10
TREM2
plgRplgR
CD163
TLR4
Siglec-5Siglec-5TLR4TLR4
TLR4TLR4
TLR4TLR4
DC-SIGNDC-SIGN
CD68 CD64CD64
CCR6IL-17 RB
CCR4
CCR9
CCR4
CCR6CCR10
TLR2
BCMA
TSLP R
ST2
CD25/IL-2 RαCD25
GITR
ICOSDR3 IL-7 Rα/CD127 IL-7 Rα/CD127
CD69
Integrin αE/CD103
CD21
TLR4
Siglec-2/CD22
IL-21 RIL-27 Rα/WSX-1/TCCR
TLR4
TLR2
IL-15 Rβ
sIgA
sIgA
sIgA
sIgA
CommensalBacterium
Innate IELInnate IEL
Adaptive IELAdaptive IEL
Anti-Microbial Peptides
Anti-Microbial PeptidesAnti-Microbial Peptides
EnterocyteEnterocyte
EnterocyteEnterocyte
Drainage to MesentericLymph Nodes
(CCR7-Dependent)
Release toCirculation
Drainage to MesentericLymph Nodes
(CCR7-Dependent)
Drainage to MesentericLymph Nodes
(CCR7-Dependent)
Gut Mucosal Homing From Circulation
(CCR9 and Integrin α4β7-Dependent)
Inflammatory LeukocyteInfiltration
Anti-microbial PeptidesCAMPCRISP-3MMP-9Leukotrienes
Anti-microbial PeptidesCAMPCRISP-3MMP-9LeukotrienesMyeloperoxidaseNeutrophil ElastaseROSProteinase 3
MyeloperoxidaseNeutrophil ElastaseROSProteinase 3
TGF-β RII
IL-10IL-22Retinoic AcidTSLP
IL-10IL-22Retinoic AcidTSLP
Epithelium-Derived Inflammatory Mediators
CXCL13/BLC/BCA-1IL-4IL-21TGF-β
CXCL13/BLC/BCA-1IL-4IL-21TGF-β
Class Switchto IgA
RnDSy-lu-2945
Mucosal Immunity of the Intestine: Homeostasis and Inflammation
Small Intestine
NOTE: This poster conveys a general overview and should be considered neither comprehensive nor definitive. The details of this information are understood to be subject to interpretation. © R&D Systems 2015
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