Supplementary Figure 4. Cerebral cortex from mice with EAE at 39 dpi immunostained for claudin-5 (a, c) and occludin (b, d). In mice with clinical score (cs) 1.5, occludin shows a better preserved linear staining pattern than that of claudin-5 (a); in a mice with cs 3, the staining pattern for both is thinner or replaced by fine puncta (c, d). Scale bars, 20 μm.