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1 Final Scientific Program Time schedule of keynote lectures and symposia List of Poster Sessions List of Participants Program Commi*ee: Tobias Bonhoeffer Nils Brose Alois Saria Stephan Schwarzacher Organizer: brainplatform.net e.U. Conference Chair: Alois Saria, Austria Contributors: Austrian Neuroscience AssociaBon InternaBonal Society for Neurochemistry Das Central AB Sciex Austria GmbH Zeiss AcalBFI HORIBA ScienBfic Peqlab TSE Systems GmbH Exhibitors: Sigma Aldrich Novus Biologicals NEUROSCIENCE WINTER CONFERENCE Sölden Austria April 9 -April 13 2013 Das Central 15th International

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1

Final Scientific Program

Time schedule of keynote lectures and symposiaList of Poster SessionsList of Participants

Program  Commi*ee:

Tobias  BonhoefferNils  BroseAlois  SariaStephan  Schwarzacher

Organizer:brainplatform.net e.U.  

Conference  Chair:Alois  Saria,  Austria

Contributors:

-­‐  Austrian  Neuroscience      AssociaBon-­‐  InternaBonal  Society        for  Neurochemistry  -­‐  Das  Central-­‐ AB  Sciex  Austria  GmbH-­‐ Zeiss-­‐ Acal-­‐BFI-­‐ HORIBA  ScienBfic-­‐ Peqlab-­‐ TSE  Systems  GmbH

Exhibitors:

-­‐ Sigma  Aldrich-­‐ Novus  Biologicals

NEUROSCIENCE WINTER CONFERENCE

Sölden AustriaApril 9 -April 13 2013

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April 9

15:00  –  16:30  RegistraBon

16:30  -­‐  17:00  Welcome  Cocktail

17:00  -­‐  19:00    Symposium  1MulBple  facets  of  serotonin  receptors  in  regulaBon  of  brain  funcBonsChair:  Evgeni  Ponimaskin  (Germany)

Vera  Niederkofler  (USA)  Decoding  the  brain  serotonergic  system:  Intersec4onal  gene4cs  and  func4onal  probingValerie  Compan  (France)  Toggling  the  serotonin  5-­‐HT4  receptors  between  acDve  and  silencing  state  switches  moDvaDon  from  restricDve  diet  towards  overeaDngAlexandre  Dayer  (Switzerland)  RegulaDon  of  neuronal  migraDon  by  the  5-­‐HT6  receptorEvgeni  Ponimaskin  (Germany)  Development-­‐dependent  regulaDon  of  synaptogenesis  and  synapDc  plasDcity  via  serotonin  receptors

WednesdayApril 10 Morning

08:15  –  09:00  Keynote  Lecture  1Peter  Scheiffele  (Switzerland)  Molecular  diversity,  recogniDon,  and  synapDc  differenDaDon

09:00  –  11:00  Symposium  2Cell  signaling  in  chronic  diseasesChair:  Gregor  Wenning  (Austria)

Poul  Henning  Jensen  (Denmark)  Oligodendroglial  degeneraDon  in  mulDple  systems  atrophy  –  FAS  and  NF-­‐kB  related  signalingTimothy  Bredy  (Australia)  NeocorDcal  Tet3-­‐mediated  DNA  hydroxymethylaDon  promotes  rapid  behavioural  adaptaDonNicolas  Singewald  (Austria)  Vulnerability  to  emoDonal  trauma:  Novel  treatment  strategies  Jörg  Striessnig  (Austria)  Voltage  gated  L-­‐type  calcium  channels  as  drug  targets  in  brain  disorders

11:00  -­‐  11:30  Coffee  Break

11:30  -­‐  13:30  Symposium  3RegulaBon  of  growth  factor  signals  during  neuronal  development  and  regeneraBonChair:  Lars  Klimaschewski  (Austria)

Georg  Dechant  (Austria)  Role  of  the  chromaDn  organizer  Satb2  in  growth  factor  driven  neuronal  plasDcityPeter  Claus  (Germany)  FGF  signaling  in  neuronal  developmentLars  Klimaschewski  (Austria)  Novel  approaches  to  accelerate  axon  elongaDon  by  enhancing  FGF  signalingKarel  Dorey  (UK)  Molecular  and  cellular  mechanisms  regulaDng  axonal  branching

WednesdayApril 10 Afternoon16:00  –  16:45  Keynote  Lecture  2Pierre-­‐Marie  Lledo  (France)  Impact  of  adult  neurogenesis  on  olfacDon

16:45  –  17:15  Coffee  Break

17:15  –  19:15  Symposium  4Stem  cells  and  adult  neurogenesisChairs:  SebasDan  Jessberger  (Switzerland)  Stephan  Schwarzacher  (Germany)  Dieter  Chichung  Lie  (Germany)  SoxC  transcripDon  factors:  BifuncDonal  regulators  of  adult  neurogenesisVerdon  Taylor  (Switzerland)  Heterogeneous  neural  stem  cells  in  health  and  regeneraDonSebasBan  Jessberger  (Germany)  Metabolic  control  of  adult  neural  stem  cell  acDvityBenedikt  Berninger  (Germany)  Oligodendrogliogenic  and  neurogenic  adult  subependymal  zone  neural  stem  cells  consDtute  disDnct  lineages  and  exhibit  differenDal  responsiveness  to  Wnt  signaling

19:30  Gala  Dinner  (free  for  Das  Central  residents,  others  book  at  registraDon  desk  for  50,-­‐  €)

ThursdayApril 11 Morning08:15  –  09:00  Keynote  Lecture  3Michael  Brecht  (Germany)  Social  neural  constructs  in  the  rat  barrel  cortex

09:00  –  11:00  Symposium  5ISN  Symposium:  OptogeneBc  control  of  moBon  and  moBvaBonChair:  Ilka  Diester  (Germany)

IIka  Diester  (Germany)  OptogeneDcs  in  the  motor  systemOfer  Yizhar  (Israel)  OptogeneDc  tool  design  and  applicaDon  in  corDcal  microcircuitsClaire  Wyart  (France)  OptogeneDc  dissecDon  of  spinal  circuits  underlying  locomoDon  in  vertebratesChrisBan  Lüscher  (Switzerland)  OptogeneDcs  and  addicDon

11:00  -­‐  11:30  Coffee  Break

ThursdayApril 11 Afternoon16:00  –  18:00  Symposium  6Mouse  models  for  auBsm  spectrum  disordersChairs:  Yuri  Bozzi  (Italy)  Michela  Fagiolini  (USA)

Michael  Saxe  (Switzerland)  Rodent  models  of  auDsm  in  drug  discoveryYuri  Bozzi  (Italy)  GABAergic  dysfuncDon  in  engrailed-­‐2  mutant  miceJennifer  Brielmaier  (USA)  Pharmacological  reversal  of  depression-­‐related  and  social  deficits  in  engrailed-­‐2  knockout  miceMichela  Fagiolini  (USA)  Circuit  dissecDon  in  neurodevelopmental  disorders

18:00  –  18:30  Coffee  Break

18:30  –  20:30  Symposium  7Altered  synapBc  funcBon  in  mouse  models  for  auBsm  spectrum  disordersChairs:  Tobias  Böckers  (Germany)Carlo  Sala  (Italy)

Stephan  Schwarzacher  (Germany)  Neuroligins  as  candidate  genes  for  auDsm  spectrum  disorders:  RegulaDon  of  synapDc  acDvity  and  plasDcity  in  vivoMarkus  Missler  (Germany)  Towards  a  pathomechanism  of  auDsm:  RegulaDon  of  synapDc  funcDon  through  Neurexophilin-­‐1/a-­‐Neurexin  complex  formaDonTobias  Böckers  (Germany)  ProSAP/Shanks  at  the  synapse:  FuncDon,  dynamics  and  their  role  in  auDsm  spectrum  disordersCarlo  Sala  (Italy)  The  funcDon  of  the  X-­‐linked  intellectual  disability  IL1RAPL1    protein  complex  at  synapses

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FridayApril 12 Morning

08:15  –  09:00  Keynote  Lecture  4Botond  Roska  (Switzerland)  Cell  type  specific  computaDons  in  reDna  and  cortex

09:00  –  11:00  Symposium  8Reinforcement  and  decision  making  in  the  developing  brainChair:  Gunter  Schumann  (UK)

Georgy  Bakalkin  (Sweden)  Shid  in  epigeneDc  regulaDon  of  opioid  genes  in  brain  of  human  alcoholicsSylvane  Desrivieres  (UK)  IdenDficaDon  and  funcDonal  characterisaDon  of  neurodevelopmental  genes  involved  in  human  cogniDonGunter  Schumann  (UK)  A  genome-­‐wide  associaDon  study  of  co-­‐expression  networks  of  brain  acDvaDon  during  reward  anDcipaDon

11:00  -­‐  11:30  Coffee  Break

11:30  -­‐  13:30  Symposium  9FuncBon  of  the  auditory  system  -­‐  From  the  cochlea  to  auditory  brainstemChair:  Josef  Syka  (Czech  Republic)

Pavel  Mistrík  and  Jonathan  Ashmore  (UK)  Molecular  motor  presDn  in  a  cellular  network  and  its  role  in  sound  amplificaDonWei  Liu  (Sweden)  The  structure  of  human  cochleaMarlies  Knipper  (Germany)  Learning  about  hearing  from  cell  specific  deleDon  of  genesJosef  Syka  (Czech  Republic)  Influence  of  postnatal  acousDc  sDmulaDon  on  neuronal  responsiveness  in  the  adult  auditory  midbrain  in  rat

FridayApril 12 Afternoon

16:00  –  18:00  Symposium  10Physiology  of  oxytocin  and  vasopressin  in  the  central  and  peripheral  systemChair:  Eva  Sykova  (Czech  Republic)Govindan  Dayanithi  (France)

Govindan  Dayanithi  (France)  Calcium  homeostasis  in  the  hypothalamic  vasopressin  and  oxytocin  neurons  and  terminalsEva  Sykova  (Czech  Republic)  ExtrasynapDc  volume  transmission  and  diffusion  parameters  of  the  extracellular  spaceHana  Zemkova  (Czech  Republic)  PotenDaDon  of  neurotransmifer  release  in  neurons  of  supraopDc  nuclus  by  presynapDc  P2X  receptorsIzumi  Shibuya  (Japan)  AcDons  of  vasopressin  in  dorsal  root  ganglion

18:00  –  19:30  Coffee  and  Poster  Session

Saturday April 13

08:15  –  09:00  Keynote  Lecture  5Karl  Deisseroth  (USA)  OpDcal  deconstrucDon  of  fully-­‐assembled  biological  systems

09:00  –  09:30  Coffee  Break  

09:30  –  11:30  Symposium  11Signal  integraBon  by  astroglia:  new  insightsChair:  Dmitri  Rusakov  (UK)

ChrisBan  Steinhaeuser  (Germany)  DisDnct  astrocyte  network  communicaDon  in  the  thalamus  Alfonso  Araque  (Spain)  SynapDc  funcDon  regulated  by  astroglia  via  endocannabinoid  and  cholinergic  signalingBrian  MacVicar  (Canada)  Neuron-­‐Glia  signaling  to  maintain  a  healthy  brainDmitri  Rusakov  (UK)  Deciphering  key  elements  of  Ca2+  signal  processing  in  astrocytes

11:30  End  of  meeBng  and  departure

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IONS Friday

April 1218:00 - 19:30 Poster Session

1.  Spontaneous  mouse  model  of  aggressive  behavioral:  Using  the  regroup  system  to  study  social  interacBonsMariana  Acquarone,  Frederico  Villas  Bôas,  Gabriel  Oliveira

2.  Intranasal  delivery  to  target  brain  aler  ischemic  brain  injury  in  ratMikko  Airavaara,  Mari  Raki,  Kim  Bergström

3.  AnBdepressant  effect  of  unpolished  Thai  purple  sBcky  rice  (variety  Luem  Phua)  aqueous  extract  in  miceTarinee  Arkaravichien,  Jintana  Safayasai,  Supawadee  Srisuwan,  Sontaya  Simasathiansophon,  Prapawadee  Puapairoj,  Acharaporn  Na  Lampang  Noenplab

4.  Over  claimed  of  dietary  supplements  and  herbal  products  for  DemenBa  and  Alzheimer’s  disease  surveyed  in  drug  store  and  internetWiwat  Arkaravichien,  Piyanoot  Samanchai,  Onnicha  Noinam,  Piyanut  Choengsa-­‐ard,  Tarinee  Arkaravichien

5.  Convergent  pathways  and  synapBc  pathophysiology  in  models  of  auBsm  and  Fragile  XStéphane  J.  Baudouin,  Julien  Gaudias,  Stefan  Gerharz,  LaeDDa  Hatstaf,  Kuikui  Zhou,  Pradeep  Punnakkal,  Kenji  F.  Tanaka,  Will  Spooren,  Rene  Hen,  Chris  I.  De  Zeeuw,  Kaspar  Vogt,  Peter  Scheiffele

6.  Human  Cav1.4  mutaBons  associated  with  congenital  staBonary  night  blindness  type  2:  New  aspects  on  wildtype  and  mutant  channelsVerena  Burtscher,  Klaus  W  Schicker,  Sakine  Korkmaz,  Christof  Kugler,  Anamika  Singh  and  Alexandra  Koschak

7.  GeneraBon  of  novel  culture  methods  for  the  differenBaBon  of  mammalian  pluripotent  stem  cells  into  reBnal  neuronsTania  Incil,  Angela  Bozza,  Andrea  Messina,  Roberta  De  Filippis,  Yuri  Bozzi  &  Simona  Casarosa

8.  Don´t  dream  it´s  over  –  Processing  aversive  experiences  increases  rapid  eye  movement  sleep  chronically  in  miceStephanie  A.  Polta,  Thomas  Fenzl,  Mafhias  Kreuzer,  Carsten  T.  Wotjak

9.  MediaBng  amnesia?  -­‐  The  informaBon  content  of  amygdalo-­‐hippocampal  interacBons  is  reduced  by  volaBle  anestheBcsMafhias  Kreuzer,  Stefan  Kratzer,  Stephanie  Polta,  Eberhard  F.  Kochs,  Thomas  Fenzl

10.  Involvement  of  TLR-­‐2-­‐related  signaling  pathway  in  the  mouse  brain  aler  ischemic  injurySrećko  Gajović,  Ivan  Bohaček,  Dunja  Gorup,  Dinko  Mitrečić,  Jasna  Križ

11.  Monitoring  of  oxygen  in  brain  Bssue  for  paBents  with  severe  brain  injuryR.  Gal,  M.  Slezak,  M.  Smrcka,  A.  Mrlian,  M.  Colonova

12.  The  5-­‐HT6  receptor  regulates  pyramidal  neuron  migraBonM.  Jacobshagen,  M.  Niquille,  A.  Dayer

13.  Gradual  synapBc  integraBon  of  maturing  adult-­‐generated  hippocampal  granule  cellsTassilo  Jungenitz,  Tijana  Radic,  Peter  Jedlicka,  Stephan  W.  Schwarzacher

14.  Fast  network  oscillaBons  in  the  lateral  septum  in  vivoTaDana  Korotkova,  Natalia  Denisova,  Alexey  Ponomarenko

15.  PrevenBon  of  cocaine  condiBoning  relapse  by  social  interacBon:  InvesBgaBng  accumbens  neuronal  network  acBvity  by  mulB-­‐electrode  arrayKummer,  K.,  Prast,  J.,  Kress,  M.,  Saria,  A.  and  Zernig,  G.

16.  Effects  of  simultaneous  use  of  ethanol  and  caffeine  on  neurogenesis  in  the  hippocampus  of  UChB  rats  (voluntary  ethanol  consumers)L.  F.  Takase;  M.  MarDnez;  D.  R.  Baltazar;  F.  S.  N.  Lizarte;  L.  F.  Tirapelli;  G.  Chuffa;  P.  F.  F.  Pinheiro;  F.  E.  MarDnez

17.  CDNF  is  not  protecBve  in  the  rodent  model  of  ischemic  injuryKert  Mätlik,  Urmas  Arumäe  &  Mikko  Airavaara

18.  Erythrina  abyssinica  ameliorates  meningoencephaliBs  and  conserves  proteins  in  trypanosoma  brucei  brucei  chronic  mice  modelNasimolo  J,  Kiama  S,  Makanya  A,  Gathumbi  P  and  Kagira  J

19.  Heat-­‐stabilizing  Bssue  samples  for  maintained  protein  integrityBeatrice  Orback,  Marcus  Söderquist,  Mats  Borén,  Karl  Sköld,  Per  Svenningsson,Per  E.  Andrén

20.  Arginine  level  in  right  inferior  parietal  cortex  and  visuospaBal  memory  declineKozlovskiy  S.A.,  Vartanov  A.V.,  Pyasik  M.M.,  Polikanova  I.S.

21.  Stargazin  (TARP  γ-­‐2)  regulates  presynapBc  AMPA  receptor  funcBon  in  cerebellar  molecular  layer  interneuronsRigby  M.,  Cull-­‐Candy  S.G.  &  Farrant  M.

22.  A  novel  animal  model  to  study  the  in  vivo  role  of  a  C-­‐terminal  regulatory  domain  in  CaV1.3  L-­‐type  calcium  channelsAnja  Scharinger,  Kai  Schönig,  Dusan  Bartsch,  Gurjot  Kaur,  Mathias  Gebhart,  Anupam  Sah,  Nicolas  Singewald,  Amy  Lee,  Alexandra  Koschak,  MarDna  J.  Sinnegger-­‐Brauns,  Joerg  Striessnig

23.  DirecBon  of  a*enBon  indicated  by  brain  direct  current  (DC)  potenBals  and  their  modulaBon  by  noiseKarin  Trimmel  and  Michael  Trimmel

5

LIST

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ANTS List of Participants

Last  Name Name Country

Acquarone Mariana Brazil

Aigner Ludwig Austria

Airavaara Mikko Finland

Alqahtani Mohammed Saudi  Arabia

Araque Alfonso Spain

Arkaravichien Wiwat Thailand

Arkaravichien Tarinee Thailand

Bähr Mathias Germany

Bakalkin Georgy Sweden

Baudouin Stephane Switzerland

Bavassano Carlo Austria

Benedel Bruno Italy

Berninger Benedikt Germany

Bock Gabriella Austria

Böckers Tobias Germany

Bonhoeffer Tobias Germany

Bozzi Yuri Italy

Brecht Michael Germany

Bredy Timothy Australia

Brielmaier Jennifer USA

Burtscher Verena Austria

Casarosa Simona Italy

Claus Peter Germany

Compan Valerie France

Cools Guy BelgiumCouillard-­‐Després SébasDen France

Daschil Nina Austria

Dayanithi Govindan Czech  Rep.

Dayer Alexandre Switzerland

Dechant Georg Austria

Deisseroth Karl USA

Desrivieres Sylvane UK

Diester Ilka Germany

Dorey Karel UK

Ebner Karl Germany

Egger-­‐Büssing Monika Austria

Fagiolini Michaela USA

Fanciulli Alessandra Austria

Fellner Lisa Austria

Fenzl Thomas Austria

Fischer Andre Germany

Flucher Bernhard Austria

Gajovic Srecko CroaDa

Gal Roman Czech  Republic

GsDr Ronald Austria

Hahnloser Richard Switzerland

Haushof Barbara Austria

Humpel ChrisDan Austria

Hüfenhofer Alexander Austria

Illes SebasDan Austria

Irschick Regina Austria

Jacobshagen Moritz Switzerland

Jensen Poul  Henning Denmark

Jessberger SebasDan Switzerland

Jungenitz Tassilo Germany

Kaindldorfer ChrisDne Austria

Keller Georg Switzerland

Kenneth Hovis USA

Klimaschewski Lars Austria

Knipper Marlies Germany

Knoflach Dagmar Austria

Korotkova TaDana Germany

Koschak Alexandra Austria

Kreutmayer Simone Sigma  Aldrich

Krismer Florian Austria

Kummer Kai Austria

Kuzdas Daniela Austria

Lakovleva TaDana Sweden

Lamarcq Laurence UK

Lange Simona Austria

Lehrmann Heike Sigma  Aldrich

Lie Dieter  Chichung Germany

Lieb Andreas Austria

Liss Birgit Germany

Liu Wei Sweden

Lledo Pierre-­‐Marie France

Lüscher ChrisDan Switzerland

Lusser Alexandra Austria

MacVicar Brian Canada

Marksteiner Josef Austria

Marschallinger Julia Austria

MarDnez Marcelo Brazil

Marvaldi LeDzia Austria

Mätlik Kert Finland

Maurer Verena Austria

Missler Markus Germany

Mistrik Pavel Austria

Murphy Connor Austria

Nasimolo Johnson Kenya

Niederkofler Vera USA

Nykjaer Anders Denmark

Obermair Gerald Austria

Orback Beatrice Sweden

Ortner Nadine Austria

Park Hae-­‐Jeong Republic  of  Korea

Pial Paolo Austria

Pinggera Alexandra Austria

Ponimaskin Evgeni Germany

Pyasik Maria Russian  FederaDon

Relg Jens Germany

Riedl ChrisDane Austria

Rigby Mark UK

Rohl Tatjana Sigma  Aldrich

Rohlmann Astrid Germany

Rosenblum Kobi Israel

Roska Botond Switzerland

Rotheneichner Peter Austria

Rusakov Dmitri UK

Russig Holger Germany

Sala Carlo Italy

Saria Alois Austria

Sartori Simone Austria

Saxe Michael Switzerland

Schafferer Simon Austria

Scharinger Anja Austria

Scheiffele Peter Switzerland

Schumann Gunter UK

Schwarzacher Stephan Germany

Shibuya Izumi Japan

Singewald Nicolas Austria

Sinitsyn Dmitry Russian  FederaDon

Stanica Ruslan Austria

Stefanova Nadia Austria

Steinhäuser ChrisDan Germany

SDcher Udo Sigma  Aldrich

Striessnig Jörg Austria

Sturm Edith Austria

Syka Josef Czech  Republic

Sykova Eva Czech  Republic

Taylor Verdon Switzerland

Thongrong Sifhisak Austria

Trimmel Michael Austria

Trimmel Karin Austria

Tuluc Petronel Austria

Vavra Vojtech Czech  Republic

Veit Markus Sigma  Aldrich

Villas  Boas Frederico Brazil

Wenning Gregor Austria

Whisböck Karin AB  Sciex

Whifle Nigel Austria

Wille Alexandra Austria

Wyart Claire France

Yizhar Ofer Israel

Zemkova Hana Czech  Republic

16th  InternaBonal  Neuroscience  Winter  Conference

April  8  -­‐  12,  2014

Das  Central,  Sölden,  Austria

www.winterneuroscience.org/2014