nicotin replacement therapy
DESCRIPTION
prevent withdrawal symptoms of TOBACOTRANSCRIPT
Introduction smoking
Smoke contents- 4000 chemicals
- 400 toxic - 43 known cancer
causing
Contents of cigarette smoke
Acetone Cyanide Aluminum DDT/Dieldrin Ammonia Ethenol Arsenic Formaldehyde Benzene Hydrogen cyanide Butane Lead Cadmium Methanol Carbon monoxide Nicotine Carbon dioxide Tar Chloroform Vinyl Chloride
Nicotine withdrawal Symptoms
• Tension
• Drowsiness
• Lack of concentration
• Irritability
Nicotine addiction Nicotine increases several neurotransmitters like dopamine These neurotransmitters cause the euphoria & relaxation to brain
Types of NRT
Nicotine Medications - Nicotine patches
- Nicotine gum
- Nicotine lozenge
- Nicotine oral inhalers
- Nicotine nasal spray
By nicotine agonists
- acetyl choline - choline - epibatidine
- lobeline - varenicline
By nicotine antagonists
- Bupropion -
mecamylamine - 18-methoxy coronaridie
Non-Nicotine Medications
Nicotine medicationNicotine medication
Nicotine patchesNicotine patches
Use: -Apply to clean skin area (upper trunk/ arms)-24 or 16 hour dosing
Dosing:
14-21mg/patch
Length of Treatment: -Up to 12 weeks
side effects
Drowsiness, hallucination Skin irritation Allergic reaction
Nicotine gum Use: Chew and park Slow, buccal
absorption Dosing: 2-4mg/dayLength of Treatment 8-10 weeks
Side effects
High amount nicotine produce irritation
Prolonged usage may cause ediction
Nicotine Lozenge
These are nicotine sublingual tablets
Nicotine is absorbed through lining of mouth
Nicotine Nasal spray/inhaler
This are aerosols contain nicotine
They are absorbed through lining of the nose and through lungs
They show quick onset of action
Side effect
Nose and throat irritation
Varenicline Partial agonist Action at 42 nicotine receptor Blocks nicotine from binding to
receptor Releases lower amounts of
dopamine
Non –nicotine medication
Dose
Treatment with Varenicline begins one week before the quit date.
0.5-1mg every day
Adverse effects Nausea Head ache Difficulty to sleep Vomiting Constipation
Bupropion
It is an α3β4 nicotinic antagonist Bupropion is a dopamine and
norepinephrine reuptake inhibitor
Start 7-10 days prior to quit dateDose150-300mg every dayContinue 7-12 weeks or longer
17
Dose
Adverse effects hypertension
Insomnia
Dryness of mouth
Seizures
CONCLUSION NRT is being provided to assist tobacco
users to become tobacco free.
NRT is not a treatment in itself, but is intended to complement the other assessments and treatments provided.
Pharmacotherapy works and is relatively safe and more effective.
Thank youThank you