Nitric Oxide (Nitrogen monoxide)Endothelial Relaxing Factor (EDRF).

* 組員B9902080 廖佩炫B9902095 盧翰生

How nitric oxide is produced? L-arginine + 3/2 NADPH + H+ + 2 O2

citrulline + nitric oxide + 3/2 NADP+

How nitric oxide is produced?

• Reduction of inorganic nitrate

• By Nitroglycerin and amyl nitrite

• Nitric oxide is generated by phagocytes

• Nitric oxide is released by neurons

1.Unrelated to body

2.related to body

Effects of nitric oxide to the human body; Vasodilation.(Penile Erection)

Mechanisms of NO Action NO is formed

diffuses into the blood

diffuses into the muscle cells

activates guanylyl cyclase

dephosphorylation of GTP

signalling smooth muscle relaxation

Effects of nitric oxide to the human body; Neurotransmission

Modifying electrical activity of neurons

Carbon monoxide Carbonous oxide

How is carbon monoxide produced• Generated by the enzyme heme oxygenase

(HO) (where it is found in the neurons in the brain or PNS ) - first example

• Vertebrate body produces small amount of CO

• During heme metabolism

Production of the Carbon Monoxide

Effects of Carbon monoxide Vasodilation Carbon Monoxide produced

activation of calcium-activated potassium channels

inducing hyperpolarizing outward currents called STOCs

smooth muscle hyper-polarization

Vasodilation

參考資料http://www.google.com.tw/images?um=1&hl=zh-TW&biw=1076&bih=412&tbs=isch%3A1&sa=1&q=MUSCLE+CELL&aq=f&aqi=g1&aql=&oq=http://en.wikipedia.org/wiki/Carbon_monoxidehttp://en.wikipedia.org/wiki/Hemehttp://nitricoxidewarning.com/nitric-oxide-supplements-find-the-best-nitric-oxide-supplement/http://www.bewellbuzz.com/general/amazing-benefits-nitric-oxide/http://blog.udn.com/jnwu/3958716http://www.forcefactorsuccess.com/best-nitric-oxide-supplementshttp://www.phagocytes.net/groups/erwig.htmlhttp://www.boatingsidekicks.com/cobro/cobrochure.htmhttp://www.cdc.gov/co/faqs.htmhttp://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/learning-center/plasma-blood-protein/hemoglobin-heme-products.htmlhttp://psychology.kenyon.edu/psy_111/week5.htmhttp://jap.physiology.org/content/100/3/1065.fullhttp://jap.physiology.org/content/100/3/1065/F1.expansion.htmlhttp://ajrccm.atsjournals.org/cgi/content/full/171/4/354http://en.wikipedia.org/wiki/Myosin_light_chain_phosphatase