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    Is your impression ofbiology limited to the dissection of frogs? It seemed like every Hollywood

    movie depicts biology lessons as one which involves dissection of frogs and mice. Well, it is not

    entirely wrong, but it does not show the whole picture. Biology encompasses more than that and it

    focuses on the natural science with regards to the study of life and living organism. So, for new SPM

    biology students in Form 4, Berry Berry Easy would like to share with you some teasers on the

    subject of biology.

    SPM Biology Form 4 Notes Terminology and Concepts: Introduction to Biology

    Light Microscope

    Biology and Its Importance

    Biology - earlier study as Botany (study of plant) and Zoology (study of animals) but now ModernBiology has many fields such as Genetic Engineering, Biotechnology and Bacteriology.

    Biology - the scientific study of life.

    Its Importance:

    1. Education.

    2. Knowledge

    3. Control

    4. Research

    5. Economy

    6. Quality of life

    7. Diseases

    8. Problem solving

    9. Careers

    Scientific Investigation

    The following are steps involved in a scientific investigation:

    1. Define the problem

    2. Form a hypothesis

    3. Plan the investigation

    4. Control the variables

    5. Collect the data6. Analyse the data

    7. Interpret the data

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    8. Make a conclusion

    9. Write a report

    Berry Berry Teacher would like to recommend young berries to follow these rules in writing their

    report:

    1. Aim / Objective

    2. Statement of problem (must be in the form of question)3. Hypothesis

    4. Variables (Manipulated, Responding and Fixed)

    5. Materials

    6. Apparatus

    7. Technique

    8. Procedure / Method of the experiment

    9. Results / Record of data

    10.Discussion / Presentation of data

    11.Conclusion (accept of not accept the hypothesis)

    So there you go, a teaser on biology. Now, does that make you wanting for more? Biology is really a

    genuinely fun and interesting subject, once you appreciate the beauty of life. Check back for more

    notes on the subsequent topics of SPM biology.

    SPM Biology Form 4 Notes Terminology and

    Concepts: Cell Structure and Cell Organisation

    (Part I)by BerryBerryTeacher on 09/02/2010

    in Berry Reference (Notes)

    Still not put off by the introduction to biology? Well, then continue on to appreciate the beauty of life

    starting with the basic structural and functional unit of all living organism, cells. This post by the

    Berry Berry Teacher will be very useful for the understanding of cells, inclusive of structure and

    organisation. This is also part 1 of the series involving cells. Be sure to compare and contrast the

    animal and plant cells if you want to understand cells.

    SPM Form 4 Terminology and Concepts: Cell Structure and Cell Organisation

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    Neuron cell

    Cell Structure and Function

    Comparison between Animal Cell (AC) and Plant Cell (PC)

    1. Mitochondrion (pl: Mitochondria): AC and PC

    spherical / rod-shaped organelles

    two membranes : Inner membrane form cristae & Outer membrane regular and smooth

    an energy source

    site of cellular aerobic respiration

    produces ATP (adenosine triphosphate)2. Nucleus (pl: Nuclei): AC and PC

    contains the genetic material

    regulates and controls the activities of the cell

    an organelle bounded by double (2) layers of nuclear membrane with pores and selectively

    permeable

    responsible for all cellular structure, chemical functions, growth and reproduction

    separates the genetic materials (chromatin) from cytoplasm

    3. Nucleolus: AC and PC

    spherical structure within the nucleus consists of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid) and proteins

    visible when the cell is not dividing

    synthesis RNA which is needed to make ribosomes

    4. Nucleoplasm: AC and PC

    fluid contained within the nucleus

    highly viscous solid

    made up of the chromatin and the nucleolus

    5. Chromosomes

    thread-like structures (consists of genetic material)

    appears as chromatin spread throughout the nucleus in the form of tiny granules

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    chromatin condenses into chromosomes (during cell division)

    carry genetic information in its DNA

    6. Ribosomes: Ac and PC

    small dot-like organelles

    protein synthesis

    consist of RNA (ribonucleic acids) smallest cellular organelles

    attached on the surface of ER and occur freely in cytoplasm

    7. Endoplasmic reticulum (ER): AC and PC

    connected to the nuclear membrane

    synthesises proteins, steroids and lipids

    collects , stores and distributes protein, steroids and lipids

    exists as rough ER and smooth ER

    Rough ER: covered with ribosomes, flat sealed sac which continued from the nuclear

    membrane, transports protein, and have a large surface area for chemical reactions. Smooth ER: does not have ribosomes, transports lipids and presents in large amounts of cells.

    8. Plasma membrane: AC and PC

    cell membrane

    thin membrane surround the cytoplasm of a cell

    selectively permeable / semi permeable

    a protective and selective outer barrier

    consists of phospholipids and protein molecules

    To be continued.. Upcoming post involves Golgi apparatus/body, Cytoplasm, Lysosome, Centriole,

    Vacuole, Cell wall, Chloroplast.

    Keys:

    AC and PC = similarities

    AC or PC = differences (Carbohydrates storage: AC = Glycogen / PC = Starch)

    SPM Biology Form 4 Notes Terminology and

    Concepts: Cell Structure and Cell Organisation

    (Part II)by BerryBerryTeacher on 12/02/2010

    in Berry Reference (Notes)

    Continuing from Part 1 of Cell Structure and Organisation, Berry Berry Easy will like to present you

    with part 2 of the same topic. The previous part involved Mitochondrion, Nucleus, Neucleolus,

    Neucleoplasm, Chromosomes, Ribosomes, Endoplasmic reticulum and Plasma membrane. So be sure

    to check out the previous post.

    SPM Form 4 Terminology and Concepts: Cell Structure and Cell Organisation

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    Neuron cell

    Cell Structure and Function

    Comparison between Animal Cell (AC) and Plant Cell (PC)

    9. Golgi apparatus / Golgi body: AC and PC

    bound sacs

    processes , packages and transport molecules synthesised in the cell

    forms lysosomes

    transports and stores lipids

    synthesis of carbohydrate from hormone changes protein into glycoprotein

    excretes waste products out of the cell

    10. Cytoplasm: AC and PC

    aqueous solution (except nucleus)

    stores water, enzymes, nutrient, salts and dissolved gases

    provided support, shape and protects the cell organelles

    medium for metabolic reactions

    provides substances

    11. Lysosome: AC sac-like organelle with one membrane

    digest proteins, lipids and carbohydrates

    removes undigested materials

    releases enzymes to digest external materials

    12. Centriole: AC

    are paired cylindrical organelles

    nine tubes with three tubules each

    produces spindle during cell division (mitosis and meiosis)

    migrate to the opposite poles of the cell (during cell division will be discussed in Chapter 5Cell Division)

    13. Vacuole: AC (temporary / lower class species) and PC

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    small cavity in the cytoplasm

    bound by a single membrane

    filled with cell sap

    storage of food (protein, oil and water)

    some vacuoles remove metabolic waste

    functions as cell expansion

    Amoeba: food vacuoles (phagocytosis)

    Paramecium: contractile vacuoles (expel water)

    14. Cell Wall: PC

    rigid and tough cellulose layer surrounding the plasma membrane (cell membrane)

    protects and supports the cell

    maintains the shape

    prevents the cell from busting (excessive intake of water)

    allows substances to move freely through the cell wall

    15. Chloroplast: PC

    disc / lens-shaped organelle

    have two membranes: inner and outer membrane

    contains chlorophyll in the grana to trap sunlight energy

    carry out photosynthesis in the chlorophyll

    storage of food and pigments

    Keys:

    AC and PC = similarities

    AC or PC = differences (Carbohydrates storage: AC = Glycogen / PC = Starch)

    The notes for this topic is not yet complete, so check out for Part III. Log on frequently to BerryBerry Easy for more notes.

    SPM Biology Form 4 Notes Terminology and

    Concepts: Cell Structure and Cell Organisation

    (Part III)by BerryBerryTeacher on 04/03/2010

    in Berry Reference (Notes)

    This is the penultimate post from Berry Berry Easy (3rd of 4) in the series of notes in Cell Structure

    and Cell Organisation. Before you all forget what is from the previous two posts, let us do a recap on

    part 2 which involvedorganelles, mitochondria for animals, chloroplast for plants and the uniqueness

    of cells. Do check out also the first post that contained Mitochondrion, Nucleus, Neucleolus,

    Neucleoplasm, Chromosomes, Ribosomes, Endoplasmic reticulum and Plasma membrane. So, do

    distinguish the difference between animal and plant cells.

    SPM Form 4 Terminology and Concepts: Cell Structure and Cell Organisation (Part III)

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    Neuron cell

    Organelles (little organ) tiny structures inside a cell that perform specific functions for a cell.

    Example: mitochondria, lysosome and chloroplast.

    Mitochondria

    Animal: High density at sperm cells (at middle piece to provide sufficient energy for motive

    power), flight muscle cells (bird / avian), liver cells, meristematic / meristemic cells (involve

    with cell division), kidney cells, heart muscle cells, brain cells.

    Chloroplasts

    Plant: High density at palisade mesophyll (leaf: below upper epidermis). It functions to trapsunlight to synthesise sugar during photosynthesis.

    The Uniqueness of The Cell

    A cell is unique:

    1. Specialisation

    2. Division of labour

    3. Coordination and integration

    Example of specialisation of cells :

    Animal smooth muscle cell, neuron (nerve cell), white blood cell, red blood cell

    (erythrocyte), cheek cell (lining epithelial cell), sperm, ovum cell (the biggest cell in human)

    Plant palisade mesophyll cell, xylem, phloem, guard cell.

    Do check out the final post in the series forSPM Form 4 Biology notes on Cell Structure and Cell

    Organisation.

    SPM Biology Form 4 Notes Terminology and

    Concepts: Cell Structure and Cell Organisation

    (Part IV)by BerryBerryTeacher on 06/03/2010

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    in Berry Reference (Notes)

    Finally, the 4th orconcluding post in the series for SPM Biology Form 4 notes on Cell Structure and

    Cell Organisation.(Do check out the previous three post on the same topic, easiest to find by clicking

    on related posts) To close this chapter, Berry Berry Easy would like to focus on cell organisation

    and their differences in various organisms. Be sure to read all four posts as a whole to understand the

    whole picture.

    SPM Form 4 Terminology and Concepts: Cell Structure and Cell Organisation (Part IV)

    Neuron cell

    Cell Organisation

    Unicellular A single cell performs all the basic life process. Example:Amoeba sp.,Paramecium sp.,

    Chlamydomonas, Bacteria and Euglena.

    Multicellular An organism consists of more than one cell. Each group of cell specialized to carry

    our life processes. Example:Homo sapien (human), animals and plants. It has five levels of

    organisation

    1. Cells: basic units of structure and function.

    Example: Red blood cells and xylem vessel cells.

    2. Tissues: made up of cells with similar in structure and function.

    Example: Epithelial tissues and vascular tissues.

    3. Organs: made up of tissues that perform a specific function.

    Example: Heart and flower.

    4. System: two of more organs that perform a specific function.

    Example: Digestive system and root system.

    5. Organisms: whole living thing that carry out all the basic life processes.

    Example: Human and durian tree.

    Cell Organisation (Unicellular) inAmoeba sp. (lives in freshwater ponds) andParamecium sp.

    (lives in soil and moist area)

    1. Cell structure

    Amoeba sp.: plasma membrane, food vacuole, contractile vacuole, pseudopodium, nucleus,

    ectoplasma, endoplasm. Paramecium sp.: food vacuole, posterior contractile vacuole, cytostome, gullet, oral groove,

    cilia, macronucleus, micronucleus, anterior contractile vacuole.

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    2. Locomotion

    Amoeba sp.: Pseudopodium (false foot) helps it to move forward slowly and it is known as

    amoeboid movement.

    Paramecium sp.: Hair-like cilia to beat against water. It beats its cilia backwards diagonally

    (swim forward) and it rotates on its axis. It beats its cilia forward (swim backwards).

    3. Feeding

    Amoeba sp.: Omnivore. Eat bacteria, plant cells, algae and other microscopic organisms.

    1. Entrapment extend pseudopodium.

    2. Engulfment engulf tiny food (phagocytosis) with its pseudopodia.

    3. Digestion food enclosed in food vacuole

    4. Absorption enzyme digests the bacteria

    5. Egesting expel indigestible material.

    Paramecium sp.: Eat bacteria, organic material and other microscopic organisms.

    1. Sweeping movement of cilia. Food moves along the oral groove into the gullet and

    cytostome.2. Digestion food vacuole circulates round the cell.

    3. Elimination undigested food is eliminated at the anal pore.

    4. Reproduction

    Amoeba sp.: two types of reproduction.

    1. Binary Fission nucleus divides (favourable condition) and then follows by division of

    cytoplasm. Two daughter cells are formed (mitotic division).

    2. Spore Formation spores form (bad condition) and germinate into new amoeba under

    favourable condition.

    Paramecium sp.: two types of reproduction.

    1. Binary Fission micronucleus undergoes mitosis (favourable condition). Macronucleus

    begins to elongation and form two. Cell content divide and two daughter cells are formed.

    2. Conjugation (Sexual reproduction) two same species parent paramecia exchange genetic

    material of their micronuclei. Each parent divides and forms four daughter cells.

    5. Osmoregulation

    Amoeba sp.: water moves into the cell by osmosis and prevention of bursting, it has a

    contractile vacuole.

    Paramecium sp.: water moves into the cell by osmosis and prevention of bursting, it has two

    contractile vacuoles.

    6. Respiration

    Amoeba sp. andParamecium sp. (both): exchange gases throughout the whole cell membrane

    7. Excretion

    Amoeba sp. andParamecium sp. (both): waste products are ammonia and carbon dioxide by

    diffusion. Solid waste in paramecium is expelled through its anal pore.

    Cell Organisation (Multicellular) in Human

    1. Cells: Epithelial cells, muscle cells, white blood cells, red blood cells, sperm, nerve cells.

    2. Tissues: Epithelial tissue, smooth muscle tissue, connective tissue, skeletal tissue, nervetissue.

    3. Organs: Stomach, heart, kidney, lung, liver.

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    4. Systems: Circulatory system, respiratory system, digestive system, excretory system,

    muscular system, lymphatic system, integumentary system, skeletal system, nervous system,

    endocrine system, reproductive system.

    5. Organisms: Human.

    Cell Organisation in Plant

    1. Cells: Parenchyma cells, collenchyma cells, sclerenchyma cells, epidermal cells.2. Tissues: Epidermal tissue, meristem tissue, vascular tissue.

    3. Organs: Leaf organ, flower organ, stem organ, root organ.

    4. Systems: Shoot system, root system.

    5. Organisms: Plant.

    So do revise on all four posts in the series if you want to understand the gist of Cell Structure and Cell

    Organisation. Especially useful forForm 4 students who are new to SPM Biology.

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    SPM Biology Form 4 Notes Terminology and

    Concepts: Movement of Substances Across the

    Plasma Membrane (Part I)by BerryBerryTeacher on 15/06/2010

    in Berry Reference (Notes)

    Berry Berry Easy is back with SPM Form 4 Biology notes for Movement of substances across

    the plasma membrane. The plasma membrane is a membrane of biological nature which forms thebarrier between the interior of a cell against external environment. However, do not just think of it as

    a layer which do not have any function. Typically, movement of substances to and from cells to outer

    environment is controlled (due to its permeability) by the plasma membrane. The key concept here for

    this topic is to understand the selective-permeability nature of a plasma membrane. The rest of the

    topic are rather easy and intuitive. Do note that plasma membrane is also known as cell membrane

    and plasmalemma.

    SPM Biology Form 4 Terminology and Concepts: Movement of Substances Across the Plasma

    Membrane (Part 1)

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    Permeability of the fruit skin

    1. Uniqueness of PlasmaMembrane (also known as cell membrane):

    it is a semi-permeable cell membrane

    it allows water and certain substances to move in and out of the cell.

    2. Importance ofPlasma Membrane:

    - cells obtain nutrients and gases

    cells excrete metabolic wastes

    cells can maintain pH for enzyme activity

    cells can maintain ionic concentration of the cells for enzyme activity control the types and the amount of substances

    allow useful substance (hormones/enzymes) to secrete from cells

    protect cells

    a boundary between the inside and outside of cell.

    3. Structure of the basic unit of plasma membrane

    Phospholipid molecule:

    Head hydrophilic: a polar phosphate molecule (philic~loves water / attracted to water)

    Tail hydrophobic: two non-polar fatty acids (phobic~hates water / repelled to water)

    Formation:

    Hydrophilic heads pointing outwardsHydrophobic tails pointing inwards

    (Bilayer phospolipid)

    Fluid Mosaic Model (Protein embedded in the bilayer)

    Carrier protein

    carrier for some molecules (glucose, amino acids, proteins and nucleic acids)

    controls the movement of ions and particles (Na+, Ca2+ and K+)

    Glycoprotein

    Glycolipid combination of lipids and polysaccharides

    4. Permeability

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    Permeability of the fruit skin

    Materials must be able to move through the plasma membrane in order for the cell cytoplasma to

    interact with the external environment. Therefore, the movement of soluble substances can occur in

    several mechanisms:

    A. Process of Passive Transport

    B. Process of Active Transport

    A. Passive Transport

    i) Simple Diffusion

    not selective: lipid-soluble molecules, gases and water.

    not control by cell.

    movement of the molecules from a region of higher concentration to a region of lower

    concentration.

    Factors affecting the rate of diffusion are temperature, size of molecules/ions, diffusion

    gradient, surface area and diffusion medium.

    example: diffusion of oxygen and carbon dioxide at the alveolus.

    ii) Osmosis:

    only water molecules.

    not control by cell.

    movement of water from a region of higher concentration to one of lower concentration and

    often occurs across a semipermeable membrane.

    strong sucrose solution = less water molecule = low water potential.

    weak sucrose solution = more water molecule = high water potential.

    example: absorption of water by root hairs.

    iii) Facilitated Diffusion:

    very specific: glucose, nucleic aicds, amino acids, protein and mineral ions.

    control by cell.

    transport of molecules (only certain molecules) across the outer membrane of living cell by a

    process of carrier protein (hydrophilic group) / channel protein (Ions: Na+, Ca2+, K+) withinthe cell membrane.

    normally take place from a region with higher concentration of molecules to a region of lower

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    concentration.

    example: absorption of digested food in the villus.

    B. Process of Active Transport

    very specific: minerals ions and amino acids.

    control by cell.

    This process needs carrier proteins and energy (due to against concentration gradient) from aregion of lower concentration to a region of higher concentration).

    Cell must expend energy that derived from ATP (adenosine triphosphate)

    example: human nerve cells (sodium ions are constantly transport out of the cell) / ions intake

    by root hairs of a plant.

    Finally, the end of this part. Stay tune for the final part (Part 3) of SPM Biology Form 4 notes on

    Movement of substances across the plasma membrane.

    SPM Biology Form 4 Notes Terminology and

    Concepts: Movement of Substances Across the

    Plasma Membrane (Part III Final)by BerryBerryTeacher on 02/07/2010

    in Berry Reference (Notes)

    Ever wondered why you need to drink isotonic drinks (100 Plus as an example) after doing sports?

    Okay, mainly because it tastes good as any sweetish cold drink after much exercise is appreciated.

    However, isotonic drinks does more than that as it replenish fluids after you lose some fluid through

    sports. Well, Berry Berry Teacher thinks that most of our knowledgeable Berry Readers knowsabout the isotonic part, but how about hypotonic and hypertonic? Hypertonic do not make you any

    more hyper, while hypotonic do not have anything to do with hippopotamus. So let us ride through

    the journey of substances across plasma membrane with Part 3 (final part) of this series.

    SPM Form 4 Terminology and Concepts: Movement of Substances Across the Plasma

    Membrane (Part 3 Final)

    Permeability of the fruit skin

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    Type of Solution

    1. Hypotonic

    2. Isotonic

    3. Hypertonic

    1) Hypotonic

    Solute concentration in the external solution is lesser than solute concentration inside the cell.

    Water concentration outside the cell is higher than the water concentration inside the cell.

    2) Isotonic

    Solute concentration in the external solution is equal to the solute concentration inside the cell.

    Water concentration inside and outside of the cell is the same.

    3) Hypertonic

    Solute concentration in the external solution is greater than solute concentration inside the

    cell.

    Water concentration outside the cell is lower than the water concentration inside the cell.Types of solutions:

    Type of

    Solution

    Hypotonic Isotonic Hypertonic

    Animal

    Cell

    The cell inflates due to

    the water molecules enter

    the cell. Eventually it

    bursts (thin plama

    membrane). Example: red

    blood cell in distilled

    water.

    No change in the

    size of cell. Net

    movement of

    water is

    zero. Example:

    red blood cell in

    0.85% sucrosesolution.

    The cell shrinks and

    becomes soft and

    dehydrated due to the

    water molecule leave the

    cell. Example: red blood

    cell in 5% sodium

    chloride solution.

    Plant Cell The cell expands and

    becomes firm / turgid due

    to the water molecules

    enter the cell. The rigid

    cellulose cell wall

    expands slightly and

    prevents cell from

    bursting. Example: strip

    of potato in distilledwater.

    No change in the

    size of cell. Net

    movement of

    water is

    zero. Example:

    strip of potato in

    5% sucrose

    solution.

    The cell becomes flaccid

    (plasmolysis occurs),

    vacuole and cytoplasma

    shrink due to the water

    molecules leave the

    cell. Example: strip of

    potato in 30% sucrose

    solution.

    Application

    1. Food is soaked in a concentrated salt solution to prevent bacteria and fungus to survive.

    2. Chemical fertiliser (dissolved ions) increases solute concentration (decrease water molecules)

    in soil. Therefore, water leaves from the cell sap of the plant which result the plant wither.

    Finally, the end of the interesting substance movement over plasma membrane. Do keep note that this

    might be a popular essay question. Easy to answer but hard to score, so take note of the terminologies

    and concepts shown above.