Our product applications

Spread all over the world

股票代码:002326

Contract ManufacturingYongtai provides contract manufacturing service for global pharma&chem innovative industries.

Key strength•Projectmanageapproach•Quickresponsiveness•Flexibility•Confidentiality•StrictlyimplementIntellectualPropertyProtection(IPP)policy

1.1ProjectInquiry

IInquiryResponse

2.1Initialreply2.2 CDA signing2.3 Technical packageevaluation2.4Projectproposal2.5 Visit/pre-audit

IInquiry Projectstart-up

3.1Projectteam/projectmanager3.2Processtransfer3.3 Lab process

01 02 03

Toller qualification

4.1Samplequalification4.2QMSaudit4.3EHSaudit4.4 CMO contract

Commercial Phase

5.1Pre-production activities5.2Production campaign5.3Productrelease5.4Projectshipment5.5Summaryreport

04 05

New Flagship Site

Total area: 120000 square meter.Total investment: USD100 millions .10 comprehensive workshops,Total

reaction volume will be 1500m3

Designed and built to comply with cGMP, will be approved by U.S. FDA later.

Key Technologies

Liquid crystal intermediate

Pharmaceutical intermediate

Agrochemical intermediate

Reaction Type (Example)

Fluorination Halogen exchange, Schiemann reaction

Halogenation Bromination, Chlorination

Photo-Chlorination/Bromination Chlorination/Bromination on aliphatic side-chain

Diazotization Sandmeyer Reaction, Gattermann Diazonium Salt Substitution reaction, Diazonium salt Hydrolysis

Organometallic Grignard, n-BuLi

Coupling Reaction Suzuki Coupling

Acylation Friedel-Crafts,

Ammonolysis Amino substitution

Reduction Catalytic Hydrogenation, Metal Hydride

Nitration Aromatic Compounds

Quality Management SystemLearning, Exploring & Improving,Customer’s satisfaction is what we are seeking for.

Each Yongtai’s site has in place a quality function, independent of production, responsible for assuring that our products are of the quality required for their intended use and that quality management systems are maintained.

Quality System

Facilities & Equipment System Laboratory C

ontrols System Materials System

Packaging & L

abel

ing

Syst

em

P

rodu

ctio

n System

QC support (IPC)

Batch sheet QA approval

Process chemist tech support

QA batch Sheetimplementation monitoring

QA review/execute batchsheet

QA release product

Pre-shipment sample

Customer approval

Shipment&Tracking

QC test

QA release

Raw material

Finished products

R&D

Two R&D centres located at Beijing and Zhejiang respectively-Total 105 hood, including 26 WALK-IN HOODDedicated Kilo labsState-of-art R&D test equipments: HPLC, GC, IR, DSC, LC-MS, GC-MS etc

Effective Project Management- Key to Success

Confidentiality

By choosing Yongtai as your partner, you get a dedicated team working in close partnership with your in-house experts.

Custom manufacturing is a trust-based business. Ensuring strict confidentiality is an aspect of our business principles which we at Yongtai Technology take most seriously.

Dedicated & experienced Project ManagersProject Managers understand the development process and commitment to meeting your timelines and other needsProject Managers enjoy the respect and cooperation of the many functions not under their direct supervisionWe establish direct contacts between your and our specialists in functions like Process Development, Analytics, QA, Regulatory Affairs and EHS.Direct communication channels lead to an efficient and smooth working process.According to your needs you will receive regular updates on your project: In telephone conferences, E-mails (e.g. weekly reports) or visits at Yongtai or at your place.

A. Strict information security regulationsB. CDA included in contract C. Confidentiality agreement with all employees D. Constant focus on Information Security E. Data archive separationF. Restricted physical and logical access management G. Selected e-mail encryption programs H. Encrypted Document Management Software installed on every computerI. Password protected network and workstation accessJ. Anti-Virus, Anti-Spam filter protection

Spread ...all over the world

Except comprehensive fluorination commercialization technology, we also developed special expertise in the following key & challenging technology area:

The largest manufacturer of fluoro-aromatic products

Suzuki CouplingGrignard, n-BuLiCatalytic Hydrogenation, 5bar~60barLow Temperature reaction (-70℃)Carbonylation by CO or CO2

Oxidization

heterocycle compound synthesis technology

Pyrazole

Pyrazine ramification

Pyrimidine

Pyridine ramification Quinazoline ramification

Indole ramification Benzimidazole ramification

NN

R2 R3

R1

NH

OR

NH

N

O

R

HN

NN

N

RN

CN

R1

R2 R3

N

N

OR

N

N

R

New Site Capability-Commercial Production

10 comprehensive workshops with refining, drying, packing and clean roomTotal 1500m3 reaction volumeHydrogenation Capacity: 3000L*4reactors Reaction temperature range: -70℃ - +250℃Pressure up to 60barsPurified water system 2t/hNitrogen gas 2 sets, 300m3/h100, 000 class Finishing Area

Yongtai’s EHS System

Our EHS work focuses on below: Environmental protection Health protection Work and process safety (HAZOP) Meet national and international EHS regulations Operate as a responsible corporate citizen Product stewardship safety Emergency management Transportation safety Continuous improvement

1000m3/d waste water disposal plant in the new site