ozonioterapia - basics - maria emilia gadelha serra
TRANSCRIPT
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Ozonioterapia
Vice-Presidente
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+ =
Oxigênio (molécula)
O que é Ozônio ?
Oxigênio (átomo) Ozônio
0 ºC ≈ 140min
20ºC ≈ 40min
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O que é Ozônio ?
É o terceiro oxidante mais potente na
natureza
10 vezes mais solúvel na água que o
oxigênio
Altamente instável, logo se recompõe
como oxigênio
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Mutação
Catarata
Retinite
Cegueira
Queimadura
Vegetação
Sistema Imune
Câncer
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Ozônio forma-se na natureza durante
tempestades elétricas (descargas
elétricas de alta potência)
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O ozônio recebeu do FDA, em 1982, a classificação “GRAS”
(Generally Recognized As Safety) para
tratamento e conservação de água e alimentos.
Ozônio “bom”
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Tratamento de Água
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Estações de Tratamento de Água
com Ozônio
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Tratamento de Piscinas
com Ozônio
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Formação de Ozônio
por Poluição
NOx = NO + NO2, metano, monóxido de carbono e compostos sulfúricos
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Ozônio “mau”
Poluente secundário
Ao nível da troposfera onde vivemos, pode ser tóxico para o trato respiratório, irritante da mucosa dos olhos e do nariz, e com alguma toxicidade para a
pele (oxidante).
Efeito inflamatório do ozônio na árvore
respiratória.
Outros gases tóxicos
presentes nas reações.
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TOXICIDADE NO AR CONCENTRAÇÃO EFEITOS
0,1 ppmv (0,2 mg/m3) Lacrimejamento e irritação no trato respiratório superior.
0,1 ppmv (0,2 mg/m3) Rinite, tosse, cefaléia, náuseas. Pessoas
predispostas podem desenvolver asma.
2 a 5 ppmv (4 a 10 mg/ m3)
10 a 20 min
Aumento progressivo de dispneia.
5 ppmv (10 mg/ m3)
60 min
Edema agudo de pulmão e ocasionalmente
paralisia respiratória.
10 ppmv ( 20 mg/ m3) Morte dentro de 4 horas.
50 ppmv ( 100 mg/m3) Morte em minutos.
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Um pouco de história...
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1840 – Basiléia, Suiça
Christian Frederick Schönbein
1785 -Martinus Van Marum
1801 -Cruikschank
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1857 – Primeiro gerador de Ozônio
Werner Von Siemens
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Alemanha 1890
Demonstração da atividade
bactericida contra diversas
bactérias : Cólera, Salmonella,
Shigela e outras
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“Therefore it qualifies ozone
therapy to be grandfathered
into acceptance.”
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Alemanha
Tratamento de feridas e gangrenas
com Ozônio
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1915 Dr. Albert Wolff,
cirurgião-chefe do
exército alemão,
amplia a utilização do
ozônio para o
tratamento tópico de
feridas infectadas, pés
congelados, gangrena
e úlceras de decúbito.
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Lancet 1916 Lancet 1917
21 casos 79 casos
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40 autores, chefes de medicina
de hospitais importantes nos
Estados Unidos, listaram 114
doenças que podem ser
tratadas com ozônio.
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Eliminou todos
os tratamentos médicos
competitivos aos
medicamentos sintéticos.
American Medical Association
(Morris Fishbein - 1933)
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Israel
Japão
México
Polônia
Rússia
Ucrânia
EUA: Alaska, California, Colorado, Florida, Georgia,
Minnesota, Nevada, New Mexico, New York, North
Carolina, Ohio, Oklahoma, Texas, Washington
Alemanha
Argentina
Brasil
Bulgária
Canadá
Cuba
Egito
Espanha
EUA
França
Hungria
Itália
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• 7 milhões de tratamentos com Ozonioterapia
todos os anos
• Os seguros-saúde na Alemanha remuneram
procedimentos variados de Ozonioterapia
desde a década de 1980
• Cerca de 10 milhões de pacientes utilizaram a
Ozonioterapia nos últimos 40 anos.
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• A Ozonioterapia é utilizada em todos os
hospitais governamentais
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Ozônio Medicinal
no Brasil
1975 - 2013
38 anos
DR. HEINZ KONRAD São Paulo
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Federação Internacional Médica de Ozônio (IMEOF) - www.imeof.org
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Ozonioterapia
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Ozonioterapia
Ozônio utilizado em Medicina
é uma
mistura de
oxigênio puro e ozônio puro.
0,05 % O 3 5 % O3 (Vol.)
99,95 % O2 95 % O2
1 µg /ml O3 100 µg/ml O3
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Dose = Concentração x Volume
“Janela Terapêutica”
1 a 100 gamas (miligramas por litro da mistura O2 e O3)
Ozonioterapia
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ULTRAVIOLETA
ELETRÓLISE
CORONA PLASMA
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Gerador de Ozônio
para Uso Médico
“ Um bom ozonioterapeuta com um gerador de
ozônio ineficiente produz má Ozonioterapia.”
Velio Bocci
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Ozonioterapia Intraperitonial
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Hidrozonoterapia
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Gás ozônio
Vidro
Teflon
Aço inox (série 300)
Ozônio diluído (em solução)
Aço inox (série 300)
PVC
Polietileno
Concreto
Plexiglass (vidro)
Teflon
Vidro
Materiais selantes
Aço inox (série 300)
Kalrez ®
Kynar ®
Teflon
Viton ®
LDPE
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Concentração Aplicação Indicação Eficácia
100 µg/ml
90
80
70
Tópica Feridas
superinfectadas
Colite
Germicida
Limpeza das
feridas
60
50
Tópica + sistêmica
Limite para o
tratamento
sistêmico
Retardo de
cicatrização
Feridas
Proctite
Germicida
Ativação do
metabolismo
celular
40
30
20
10
Sistêmica Desordens
circulatórias
arteriais
Desequiíibrio
imunológico
Revitalização
Melhora da
cicatrização
Ativação do
metabolismo das
hemácias
Imunomodulação
Aumento de anti-
oxidantes e de
varredores de
radicais livres
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644 especialistas em ozônio 384.775 pacientes 5.579.238 tratamentos 40 casos com efeitos colaterais
A mais segura das terapias médicas ( 0,0007%)
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Ozonioterapia Formas de aplicação
Aplicação de óleo ozonizado
Água (bi)destilada ozonizada
(compressa, spray, bochecho,
irrigação ou banho)
Inalação de óleo ozonizado
(triozonides de trioleínas)
Bolsa (bag)
“Ventosa“
Sauna
Banho de vapor ozonizado
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Local / Tópico
Injeção intramuscular
Injeção paravertebral
Injeção subcutânea
analgesia
drenagem linfática
fins estéticos
Injeção intra/periarticular
Injeção intradiscal
Injeção plexo pterigoideo
Injeção tonsilar
Insuflação retal, vaginal,
bexiga, orelha
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Patologias
vasculares
Infecções
Modulação Imunológica
& Inflamatória
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Patologias
vasculares
Infecções
Modulação Imunológica
& Inflamatória
Dçs Ortopédicas / Reumatológicas: artroses,
osteoartrites, fibromialgia, AR, sínd. miofascial,
dores articulares, lombalgias
Isquemia Crônica (DM,
aterosclerose, Buerger,
úlceras venosas e arteriais,
patologias cerebrais e
coronarianas)
Abscessos e fístulas anais,
escaras de decúbito,
furunculoses,
osteomielites,
vulvovaginites, fasciítes
necrotizantes, úlceras
infectadas
Dçs Neurodegenerativas
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Patologias
vasculares
(úlceras de
extremidades,
AVC, olho, orelha
interna)
Infecções
Modulação Imunológica &
Inflamatória
(alergias. doenças auto-imunes, dor
crônica)
GAHT ou
Insuflação retal,
Bolsa
GAHT ou Insuflação retal, PAHT, Injeção
subcutânea, Injeção intramuscular,
Injeção intra/periarticular
GAHT ou Insuflação
retal, Bolsa
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Reinfusão de
sangue
ozonizado
Grande
Auto-Hemoterapia
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Indicações
Desordens circulatórias arteriais
Imunomodulação e imunoativação
Inflamações crônicas
Doenças reumáticas - AR
Infeções
Cicatrização de feridas
Terapia de readaptação
Terapia adjuvante em câncer
Patologias geriátricas
Grande Auto-hemoterapia
Indicações
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INSUFLAÇÃO RETAL
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Ozônio e Mucosa Intestinal
Dissolve rapidamente em água
Reação imediata com qualquer biomolécula (ppt. PUFAs), produzindo ROS e LOPs
Mucosa intestinal com cobertura abundante pelo glicocálix e espessa camada de água contendo mucoproteínas e outros produtos com capacidade antioxidante
Conteúdo fecal interfere na ação (insuflação após defecar ou enema)
Ação do ozônio pelas LOPs (atividade local e/ou sistêmica), que entram na circulação via capilares linfáticos e venosos
Concentração máxima: 40 mcg/ml
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O sistema MALT Da orofaringe ao intestino encontram-se estruturas linfáticas (gânglios linfáticos solitários, placas de Peyer) afins às de outros âmbitos mucosos (vias respiratórias, urogenitais, etc.)
O MALT é um sistema funcional
caracterizado pela troca integrada
de células e moléculas entre todas as
superfícies mucosas do organismo.
Mucosa
Associated
Lymphoid
Tissue
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MALT
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Knoch, H.G., Roschke, W., Klug, W.
"Die Sauerstoff-Ozontherapie in der
Proktologie“
Aktuelle Koloproktologie 4: 161-173 (1987)
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INSUFLAÇÃO RETAL DE OZÔNIO
(COLITE – MÉTODO DE KNOCH)
1ª. Semana (3 dias): 20 mcg/mL, 300 mL de gás
2ª. Semana (3 dias): 25 mcg/mL, 300 mL de gás
3ª. Semana (3 dias): 30 mcg/mL, 400 mL de gás
4ª. Semana (3 dias): 30 mcg/mL, 500 mL de gás
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Estágio florido de retocolite
• destruição do epitélio
• abscessos de cripta
• infiltração leucocitária maciça
Biópsia de controle após 4
semanas:
• epitélio intacto
• reversão da inflamação
RETOCOLITE ULCERATIVA
Insuflação retal
20-30 µg/ml
300-500 ml
Fem, 45a (Knoch et al. „Aktuelle Koloproktologie“)
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Estágio florido de colite
• destruição do epitélio
• abscessos de cripta
• inflamação crônica com
infiltração leucocitária maciça
Biópsia de controle após 4
semanas:
• epitélio intacto
• aspecto normal das criptas
• reversão da inflamação
• infiltração leucocitária
moderada
COLITE ULCERATIVA
Insuflação retal
8,5-27 µg/ml
300 ml /dia,
3x/semana
Masc, 62 a (Knoch et al. „Aktuelle Koloproktologie“)
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Ozônio e Mucosa Intestinal
Bocci
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Insuflação Retal - Cuba
5 dias 5 dias 5 dias 5 dias
Concentração
(mcg/ml) 20-25
30 35 40
Volume
(ml) 100 100 150 200
Função Pré-
condiciona-
mento
Imunomodula-
ção
Imuno-
estimulação
Imuno-
estimulação
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Ozonioterapia
Insuflação Retal
PRÉ
PÓS
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Minor Auto Hemo Therapy Ozonioterapia
Pequena Auto-hemoterapia
Indicações Alergias
Acne
Furunculose
Terapia adjuvante
de câncer
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• Sistêmicas: PAHT
• Indicações:
Acne
Alergias
Imunomodulação
Pequena Auto-Hemoterapia
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Pequena Auto-hemoterapia com Ozônio
www.thelancet.com
Vol 371 January 19, 2008
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Indicações
Síndrome
miotraumática
Miogelose
Hérnia de disco
Em combinação com
tratamento
fisioterápico
Injeção Subcutânea
e Intramuscular
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Injeção Intra-articular
e Periarticular
Indicações
Artrite reumatóide
Artrose do joelho,
ombro, quadril
Distúrbios traumáticos
do joelho
Síndrome do ombro
doloroso
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Bolsa Plástica (Bag)
Indicações
Úlceras (venosas,
arteriais e diabéticos)
Dermatoses
Infecção fúngica
Feridas de
queimaduras
localizadas e extensas
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DR. HEINZ KONRAD
Ozônio entra
Ozônio sai
Garroteamento
leve
Saco plástico comum,
transparente
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Hidrozonoterapia
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Como age
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A: neutrófilo em repouso AMP: polipeptideos
antimicrobianos
MPO: mieloperoxidase
Phox: complexo oxidase do
fagócito
Rac : Phox associado a membrana
B: neutrófilo ativado
C: reação catalisada por anticorpo
Science 298, Dez. 2002
OZÔNIO -
BIOMOLÉCULA
produzida por neutrófilos ativados e catalisada por anticorpos específicos
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Reação com água
Reação com ligações duplas de carbono – fosfolipídeos de
membranas celulares
Produção de “ozonides” (peróxidos, hidroxiperóxidos, aldeídos)
Sinalização celular
Desencadeia efeito anti-oxidante secundário
Mecanismos de ação
da ozonioterapia
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Ativação do metabolismo das hemácias - ↑ 2,3 difosfoglicerato e G6PDH » ↑ oxigenação tissular
Melhora das condições hemorreológicas
Ativação de células
imunocompetentes e
plaquetas – moléculas de
sinalização – IF, IL, fatores
de crescimento
Reação com
anti-oxidantes plasmáticos
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Em ordem de preferência, ozônio reage com:
Dependendo da dose, ozônio reage com carboidratos e enzimas. DNA e RNA podem também ser afetados.
Todos estes compostos agem como doadores de elétron e são submetidos à oxidação.
1 • ácidos graxos poliinsaturados (PUFA)
2 • antioxidantes como ácido ascórbico e ácido úrico
3
• compostos c/grupos – SH, como cisteína, glutationa reduzida (GSH)
4 • albumina
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LOPs
Coração SNC
TGI
Ossos
Músculos
Glândulas
Pulmões
Baço
Pele
MALT
Sangue
ozonizado
Fígado Bile Rins Urina
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Os efeitos biológicos imediatos do Ozônio Medicinal
podem ser resumidos...
3- Regulação do sistema
antioxidante e radicais
livres
1- Ativação do metabolismo
das hemácias
2 - Ativação das células
imunocompetentes
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Reação de peroxidação sobre os fosfolipídios de membrana, determinando um aumento da carga elétrica negativa na membrana eritrocitária, evitando um empilhamento ou roleaux e de outra forma promovendo um relaxamento sobre a membrana, tornando o eritrócito mais deformável
Melhora liberação de oxigênio tecidual
Flexibilidade de membrana
Fenômeno antisludging (sedimentação)
1- Ativação do metabolismo das hemácias
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● Formação de peróxidos ● Ativação do metabolismo das hemácias -
↑ 2,3 difosfoglicerato e G6PDH » ↑ oxigenação tecidual
● Melhora das condições reológicas
O 2,3-DPG, encontrado em grande quantidade nos eritrócitos e em pequenas quantidades nos tecidos, desvia a curva para a direita, diminuindo a afinidade da hemoglobina pelo oxigênio.
1- Ativação do metabolismo das hemácias
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Estudo com amostra de 78 pessoas Barkhotkina T., et al. National Polytechnic University, Medical Center. Ukraine, Kharkov
ESQUEMA DE DETERMINAÇÃO DO COEFICIENTE DE ESFERICIDADE
TIPOS BÁSICOS DE ERITRÓCITOS
DEMONSTRADOS NA MICROSCOPÍA
HOLOGRÁFICA INTERFERENCIAL
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ERITRÓCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA
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CARACTERÍSTICA MORFOLÓGICA DOS ERITRÓCITOS
Tipo de eritrócito
Voluntários saudáveis Pacientes com inflamação
Pacientes com
hipóxia
Antes O3 Depois O3 Antes O3
Depois O3
Antes O3
Depois O3
Discóide biconcavo
96,78% 97,6% 13% 81% 17% 79%
Eritrócito plano 2,7% 1,9% 75% 17% 69% 20%
Esferócito 0,5% 0,4% 12% 2% 14% 1%
Coeficiente de esfericidade médio
0,46 0,46 1,0 0,51 0,98 0,69
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Pré-ozônio Pós-ozônio
Efeitos da Ozonioterapia
10 minutos
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Ozonioterapia em Doenças
Vasculares Isquêmicas Vasodilatação pós-aplicação subcutânea
Indução da Óxido Nítrico sintetase
Aumento do Óxido Nítrico
Vasodilatação
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Ativação de células imunocompetentes com indução de citocinas como interferons, interleucinas e fatores de crescimento (moléculas sinalizadoras)
Interferons (IFN-, IFN-, and IFN-)
Interleucinas ( IL-1b, 2, 4, 6, 8, 10, 12)
Fator de necrose tumoral (TNF - )
Fator estimulador da formação de colônias
de granulócitos / Macrófagos (GM-CSF)
Fator de crescimento transformador ( TGF-β1)
2 - Ativação das células imunocompetentes
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Indução de Citocinas pelo O3 (Bocci 1996)
:
Hidroxiperóxidos de cadeia curta entram no núcleo das células e ativam o fator nuclear NF-kB (Haddad et al 1996)
Através da ativação do mRNA, transcrição e correspondente síntese proteica, ocorre liberação de citocinas (Paulesu et al 1991, Dee Forge et al 1992,
Andreson et al 1994, Schenk et al 1996, Sen and Packer 1996, Bocci 1996, Flohe et al 1997, Ginn-Pease and Whisler 1998, Hack et al 1998, Arrigo 1999, Tatla et al 1999, Allen & Tresini 2000, Larini et al 2001)
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Bioquímica do Ozônio
0
50
100
150
200
250
300
350
400
450
IFN-g IL-6 TNF-a
oxygen
11 µg
25 µg
42 µg
78 µg
Indução de citocinas: interferons, interleucinas e fatores de crescimento (Bocci et al., 1990)
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Indução de Citocina concentração de ozônio de 42µg/ml (Bocci 1998) - em (iu/ml)
Bioquímica do Ozônio
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Th0
IL-12
IL-4
IL-2
IFN-
TNF-
TGF-
IL-4
IL-5
IL-10
IL-13
Resposta
predominante
IgG2a
IgG3
DTH
Mac
IgE
IgG1
Eos
Patógenos
intracelulares
(Micobactérias e
Virus), Protozoários,
Células tumorais,
Hipersensibilidade
tardia
Patógenos
extracelulares,
Parasitas, Alergia IgE,
Auto-imunidade por
Ac/Imunocomplexos
Th1
Th2
Ozonioterapia
Citocinas
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Ação da Ozonioterapia no
Tecido Adiposo
Modulação de enzimas e citocinas inflamatórias
Lipólise
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2 GSH + H2O2 GSSH
+ 2 H2O GLUTATIONA
PEROXIDASE
H2O2 + H2O2 2H2O + O2 CATALASE
O2 + O2 + 2 H H2O2 + O2 -
S.O.D.
- +
As enzimas anti-oxidantes SUPERÓXIDO DISMUTASE (SOD), CATALASE (CAT) e GLUTATIONA PEROXIDASE (GPx) servem como linha primária de defesa na destruição dos radicais livres.
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O Homem “radical livre”
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O +
O - O -
O ozônio não é uma molécula
radicálica porque possui um
número par de elétrons na órbita
mais externa (BOCCI, 2000),
porém é muito oxidante e por isso
reage instantaneamente com
outras moléculas podendo
transformá-las em radicais livres
(RL): ROIs, LOPs, nutrientes....
Ozônio é um radical livre ?
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León, Bocci et al., 1998
Peralta et al., 1999
Ativação de enzimas anti-
oxidantes e varredores de
radicais livres - nas células
saudáveis 0
10
20
30
40
50
60
70
SOD GSH
Kontrolle Ischaemia/Reperfusion Ozone+I/R
H2O2
Protective effect of ozone in
Hepatic Ischaemia - Reperfusion
3- Regulação do sistema antioxidante e radicais livres
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Ozonioterapia
- dentro da janela terapêutica -
induz stress oxidativo
leve, controlado e transitório.
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Proteção contra dano celular hepático induzido por tetracloreto de carbono
em modelo animal 10 Insuflações retais antes aplicação de CCl4 (León et al. 1998)
SOD (u/g)
CCl4 O3+CCl4 O2+CCl4
Bioquímica do Ozônio
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Potente ação microbicida do ozônio a nível local.
Ozônio e Ação Antimicrobiana
Efeitos sistêmicos antivirais e antimicrobianos:
bactericida, fungicida e inativação viral (virustático).
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Glacus de Brito
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Oxigênio - 30 minutos
Glacus de Brito
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Ozônio a 5 mcg/ml Ozônio a 2,5 mcg/ml Ozônio a 1,2 mcg/ml
Glacus de Brito
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Eletronic Photomicrography of
Bacterial Membrane Lesion by
Ozone
By WENTWORTH ET AL
Science, November 2003.
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Unifenas (1999)
200 Cadeiras Odontológicas
Cláudia Cardoso
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Remoção de Biofilme
com Ozônio
Cláudia Cardoso
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Ozônio pode alterar diretamente estruturas no envelope viral (peplômeros – protuberâncias glicoproteicas que se ligam aos receptores das células hospedeiras)
Ozônio e Ação Antiviral
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Ozônio e Mucosa Oral/Labial
Herpes labial
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Modula o estresse
oxidativo biológico
Incrementa o
metabolismo
do oxigênio
Influi na síntese e
liberação de
eicosanóides
Poder
Germicida
Modulador Imunológico
Regulador
Metabólico
e da
Reologia
Efeitos Biológicos do Ozônio
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Patologias
vasculares
Infecções
Modulação Imunológica
& Inflamatória
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Ozonioterapia Tópica
Água Ozonizada Óleo Ozonizado Ozônio/Oxigênio
Ozonoterapia tópica
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Efeito microbicida (bactericida,
fungicida e virustático)
Limpeza da ferida
Cicatrização da ferida
Imunoativação tópica
Ozonioterapia
Aplicações Tópicas
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15 dias depois...
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15 dias depois...
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25 dias depois...
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25 dias depois...
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Água Ozonizada
em Queimaduras
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Hidrozonoterapia
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Hidrozonoterapia
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Hidrozonoterapia
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Pré-ozônio Pós-ozônio
Hidrozonoterapia
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Hidrozonoterapia e
Úlcera Venosa
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Hidrozonoterapia e
Úlcera Venosa
Após 25 dias de tratamento
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Hidrozonoterapia e
Úlcera Venosa
Após 37 dias de tratamento
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Hidrozonoterapia e
Úlcera Venosa
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Hidrozonoterapia e
Úlcera Venosa
Após 25 dias de tratamento
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Hidrozonoterapia e
Úlcera Venosa
Após 30 dias de tratamento
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Queimadura de 1º, 2º e 3º graus
(Álcool)
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Queimadura de 1º, 2º e 3º graus
(Álcool)
Após 07 dias de implante de Matriz de Regeneração Dérmica
+ Hidrozonoterapia
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Queimadura de 1º, 2º e 3º graus
(Álcool)
Após 21 dias de Hidrozonoterapia
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Hidrozonoterapia e
Dermatite pós-trombótica (9 anos)
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OZONE THERAPY IN
DIABETES MELLITUS
Silvia Menéndez, Olga S. León1, Saied M. Al-Dalien1,
Gregorio Martínez1, Eduardo J. Candelario1, Héctor
Alvarez2 and José I. Fernández-Montequín2
Ozone Research Center, 1Center of Studies for Research and
Biological Evaluation, 2Institute of Angiology and Vascular Surgery
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Local ozone treatment using
plastic bags
OLEOZON
application
Ozone treatment by rectal
insufflation
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A-Before B-After 20 days of
ozone treatment
C- Before D- After 20 days of ozone
treatment
Representative photos of the area and perimeter reduction of the lesions,
before (A, C) and after 20 days of ozone treatment (B, D), in 2 patients selected
at random.
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Amputations present in both treatments
5,7
14
0
2
4
6
8
10
12
14
Amputations
Ozone
Antibiotic
%
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Preliminary economic evaluation
Ozone therapy
(O)
Antibiotic
therapy (A)
Ratio between
both
treatments:A/O
Daily expenses in medication/patient
(MN) 1.35 26.54
19.65
Expenses in medication/patient
(MN) * 35.85 883.25
24.63
Hospitalization Expenses/patient
(MN) * 1687.0 2159.7
1.28
Total Expenses/patient
(MN) * 1723.1 2997.2
1.74
MN, Cuban pesos; (*), calculated for a mean time of hospitalization (34 days for Antibiotic, 26 days for Ozone).
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Combinação de Técnicas
Pequena auto-hemoterapia +
Infiltração subcutânea de ozônio nas bordas da lesão +
Bolsa plástica +
Aplicação de óleo ozonizado
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SWEET, F.
Ozone selectively inhibits growth of
human cancer cells.
SCIENCE Vol. 209, August 22, 1980.
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Silvia Menendez
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Os protocolos de ozonioterapia utilizados na
prevenção e tratamento de tumores
incluem combinações variadas de:
grande auto-hemoterapia (GAHT)
pequena auto-hemoterapia (PAHT)
insuflação retal
ozonioterapia intraperitoneal (resultados
preliminares muito promissores no
controle e até mesmo erradicação de
tumores agressivos)
infiltração local da mistura gasosa no
tumor
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Radioterapia
A RXT age por lesão no DNA e é sabido
que a lesão ao DNA é menor na ausência
de oxigênio, ou seja, o oxigênio sensibiliza
as células à ação da RXT. Clinical trials
com tumores de cabeça e pescoço têm
demonstrado que os tumores mais
hipóxicos (com pO2 médio menor que 10
mmHg) são mais radioresistentes que os
menos hipóxicos.
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A Ozonioterapia melhora o desempenho nos esportes
• Facilita a recuperação de lesões decorrentes de traumas frequentes
(hematomas, tendinites, lesões articulares, ciática)
• Reduz a necessidade de cirurgias, em função da sua atividade
moduladora da inflamação
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Ozonioterapia em Estética
Academia Médica de Moscou
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Protocolo Kosheleva Ultrassom de Alta Freqüência
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PRÉ PÓS
Protocolo Kosheleva Ultrassom de Alta Freqüência
Derme e Hipoderme
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PRÉ PÓS
Protocolo Kosheleva Ultrassom de Alta Freqüência
Derme e Hipoderme
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Protocolo Kosheleva
Monitoramento com Vídeo da
Superfície Cutânea
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PARÂMETROS ASPEREZA RUGOSIDADE SUAVIDADE RUGAS
LINHA DE
BASE 2.7 ± 0.31 0.83 ± 0.12 38.75 ± 8.33
43.13 ±
6.0
DEPOIS DO
TRATAMENTO 2.08 ± 0.37 0.61 ± 0.50 47.57 ± 6.98
32.73 ±
5.20
% - 23% - 26% + 18% - 31%
PARÂMETROS SELS
IMAGEM 3D DA SUPERFÍCE CUTÂNEA
PRÉ PÓS
Protocolo Kosheleva
Monitoramento com Vídeo da Superfície Cutânea
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Kosheleva
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Kosheleva
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PRÉ PÓS
Protocolo Kosheleva
Celulite
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Hemograma com VHS
Glicose 6-fosfato desidrogenase
Glicemia (e insulina)
Ferro sérico livre e ferritina
Função tireoidiana
Função hepática
Função renal
Perfil lipídico
Avaliação do estresse oxidativo
Microscopia
MDA
Avaliação Laboratorial
Pré-Ozonioterapia
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Rota da Hexose Monosfosfato: além das enzimas antioxidantes, a
G6PD dá início ao sistema de proteção oxidativo.
Deficiência ou ausência de NADPH e glutationa: responsáveis pela eliminação do grupo sulfidrila formado na oxihemoglobina,levando à sua precipitação dentro do eritrócito, causando hemólise intravascular.
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Esta reação ocorre em todas as células do indivíduo afetado, mas é mais severa nos eritrócitos, onde a G6PD é o único meio de formar NADPH.
O3
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Intoxicação por Ozônio
• Decúbito
• Inalação de oxigênio umidificado
• EV lento: Ac Ascórbico+ GSH reduzida
em SG 5%.
• VO: Ac. Ascórbico + Vit E + NAC
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Ozonioterapia Contra-Indicações
CONTRA-INDICAÇÕES ABSOLUTAS
1. Deficiência de glicose 6-fosfato desidrogenase (Favismo)
2. Hipertireoidismo descompensado
3. Anemia grave
CONTRA-INDICAÇÕES RELATIVAS
Início da gravidez
Trombocitopenia
Ferro sérico livre alto
HIV – tardio
Patologias com alto stress oxidativo (compensar primeiro)
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Ozonioterapia em Odontologia
Acervo fotográfico Dra. Sonia Lia
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Ozonioterapia em Veterinária
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http://www.ozonosan.de/images/upload/File/Diabetic%20feet%20badly%20healing%20wounds%20Fathi,%20Mawsouf%20%2011.2008.pdf
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HIPERBÁRICA
OZÔNIO
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Cadillac 1953
Cadillac 1953
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Tel: 21 3565-6831 - Cel: 21 8151-3139 Fax: 21 2431-0920
Avenida das Américas, 2250 – Cj. 212 – Barra da Tijuca
Rio de Janeiro – RJ – CEP 22640-101 [email protected] – www.aboz.org.br
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Dr. Alexandre Padilha
Ministro da Saúde do Brasil
19 de maio de 2011
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4 de outubro de 2011
Dr. Roberto d´Ávila
Presidente do Conselho Federal de
Medicina
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Dr. Dirceu Barbano
Presidente da ANVISA
18 de janeiro de 2012
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Uso secular
Técnica segura
Baixo custo
Otimiza os resultados de outras
técnicas de tratamento
Útil como tratamento complementar ou
isolado
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The Fountain of Eternal Youth
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D 021-0002 11.11.2004
Obrigada pela atenção !
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Tel: 11 3165-6777 www.institutoalpha.com.br [email protected]