pain control and research 2009 in nagasaki japanvi koichi noguchi: molecular mechanism of...

Project leader: Hiroshi Ueda, Ph.D., Professor Nagasaki University Center for Pain Research (NUCPR)

1-14 Bunkyo-machi, Nagasaki 852-8521, Japan +81-95-819-2421 (Phone), +81-95-819-2420 (Fax)

[email protected] (E-mail) http://www.mdp.nagasaki-u.ac.jp/pain/index_e.html

長崎大学重点研究課題

「痛み克服の国際的研究教育拠点の形成」

第 1回国際シンポジウム

Pain Control and Research 2009 in Nagasaki JAPAN

2009 年 3 月 13 日（金）̶14 日（土）

会場：長崎大学医学部良順会館

長崎大学

「痛み克服の国際的研究教育拠点の形成」事務局

プロジェクトリーダー：植田弘師




講演内容 1. Stephen B. McMahon (King’s College London, UK)

Mechanisms of Neuropathic Pain

2. Jon D. Levine (University of California at San Francisco, USA)

Toward a Cell Biology of Pain

3. Eija Kalso (Helsinki University, Finland)

Genetics of Pain and Opioid Analgesia

4. Brigitte L. Kieffer (IGBMC, France)

Delta Opioid Receptor Gene Targeting and Pain

5. 井上和秀 (九州大学)

IFN-γ Receptor-mediated Activation of Spinal Microglia in Neuropathic Pain

6. 伊藤誠二（関西医科大学）

Prostaglandins as Intercellular Messengers in the Spinal Cord

7. 片山容一（日本大学）

Chronic Thalamic Stimulation for Peripheral Neuropathic Pain Control in Humans

8. 野口光一（兵庫医科大学）

Molecular Mechanism of Inflammatory Pain




9. 山本達郎（熊本大学）

Role of N-Acetylaspartylglutamate (NAAG) in the Nociceptive Transmission

10. 鳥巣哲朗（長崎大学）

Chronic Orofacial Pain -Effects of Jaw Exercise-

11. 上園保仁（長崎大学／国立がんセンター研究所）

Visualization, biochemical and functional analyzes of µ-opioid and cannabinoid CB1 receptors: implication of interaction between morphine and cannabinoids at the receptor levels

12. 植田弘師（長崎大学）

Pain and Opioid Research - to overcome opioid-resistant chronic pain and opioid analgesic tolerance ___________________________________________________________________________ Special Lecture 1. 岡村均（京都大学）

Molecular Dissection of Circadian Clock and Diseases

2. 岡野栄之（慶応大学）

Neural Differentiation and Cell Therapy using Pluripotent Stem Cells




The Ist International Symposium

on Pain Control and Research in Nagasaki

March 13(Fri.)- 14(Sat.), 2009

Venue: Ryojun Auditorium, Nagasaki, Japan

Nagasaki University,

Nagasaki University Center for Pain Research (NUCPR)

Leader: Hiroshi Ueda

Speakers

Lecture Eija Kalso (Helsinki Univ.)

Brigitte L. Kieffer (IGBMC)

Jon D. Levine (UCSF)

Stephen B. McMahon

(King’s College London)

Special Lecture Hitoshi Okamura (Kyoto Univ.)

Kazuhide Inoue (Kyushu Univ.)

Seiji Ito (Kansai Medical Univ.)

Yoichi Katayama (Nihon Univ.)

Koichi Noguchi

(Hyogo College of Medicine)

Tatsuo Yamamoto

(Kumamoto Univ.)

Tetsuro Torisu (Nagasaki Univ.)

Yasuhito Uezono (Nagasaki Univ.)

Hiroshi Ueda (Nagasaki Univ.)

Hideyuki Okano (Keio Univ.)




Lectures

I Hiroshi Ueda: Pain and Opioid Research - to overcome

opioid-resistant chronic pain and opioid analgesic tolerance II Stephen B. McMahon: Mechanisms of Neuropathic Pain III Jon D. Levine: Toward a Cell Biology of Pain IV Yoichi Katayama, Takamitsu Yamamoto: Chronic Thalamic

Stimulation for Peripheral Neuropathic Pain Control in Humans

V Tetsuro Torisu: Chronic Orofacial Pain -Effects of Jaw Exercise- VI Koichi Noguchi: Molecular Mechanism of Inflammatory Pain VII Kazuhide Inoue: IFN-γ Receptor-mediated Activation of Spinal

Microglia in Neuropathic Pain VIII Seiji Ito: Prostaglandins as Intercellular Messengers in the Spinal

Cord IX Tatsuo Yamamoto: Role of N-Acetylaspartylglutamate (NAAG)

in the Nociceptive Transmission X Eija Kalso: Genetics of Pain and Opioid Analgesia XI Yasuhito Uezono, Minoru Hojo, Yuka Sudo, Yuko Ando, Takehiro

Matsubara, Koji Sumikawa: Visualization, Biochemical and Functional Analyzes of µ-opioid and Cannabinoid CB1 Receptors: Implication of Interaction between Morphine and Cannabinoids at the Receptor Levels

XII Brigitte L. Kieffer, C. Gavériaux-Ruff: Delta Opioid Receptor

Gene Targeting and Pain




Special Lectures

I Hitoshi Okamura: Molecular Dissection of Circadian Clock and

Diseases

II Hideyuki Okano: Neural Differentiation and Cell Therapy using

pluripotent stem cells




Poster Session Yuko Ando, Minoru Hojo, Masafumi Takada, Yuka Sudo, Koji

Sumikawa, Yasuhito Uezono: Distinct internalization and recycling profiles of µ-opioid and dimerized µ-δ opioid receptors in response to each opioid

Weijiao Xie, Misaki Matsumoto, Makoto Inoue, Jerold Chun, Hiroshi

Ueda: Pharmacological and biochemical characterization of sensory fibers and plasticity in neuropathic pain

Ryo Yano, Yosuke Matsushita, Jun Nagai, Ryousuke Fujita, Junken

Aoki, Jerold Chun and Hiroshi Ueda: LPA1-dependent Dorsal Root Specific Demyelination in Neurophatic Pain Model

Ma Lin, Makoto Inoue, Nobuyuki Fukushima, Junken Aoki and

Hiroshi Ueda: The de novo biosynthesis of LPA, an initiator of neuropathic pain, following intense stimulation of primary afferent fiber

Hitoshi Uchida, Misaki Matsumoto and Hiroshi Ueda: Profiling of

BoNT/C3-reversible gene expression induced by LPA Tomoka Uemura, Ryousuke Fujita and Hiroshi Ueda:

Lysophosphatidic acid-induced membrane ruffling and brain-derived neurotrophic factor gene expression are mediated by ATP release in primary microglia

Michiko Nishiyori, Jun Nagai, Tomoyo Ogawa, Ayumi Mori and

Hiroshi Ueda: Prolonged gabapentin analgesia in an experimental mouse model of fibromyalgia




Program

March 13th, 13:30~ (Bauduin Hall) 13:30~14:20 Opening Ceremony

Shigeru Katamine (President of Nagasaki Univ.) Susumi Hatakeyama (Dean, Sch. Pharmac. Sci)

Introduction of NUCPR Hiroshi Ueda (Nagasaki Univ./Project Leader)

14:20~14:50 Lecture I (Chairman: Yoshihiko Hayashi) Hiroshi Ueda (Nagasaki Univ.) 14:50~15:30 Lecture II (Chairman: Kazuo Toda) Stephen B. McMahon (King’s College London) 15:30~15:50 Coffee Break and Poster Session 15:50~16:30 Lecture III (Chairman: Kumiko Oi) Jon D. Levine (UCSF) 16:30~17:00 Lecture IV (Chairman: Koji Sumikawa) Yoichi Katayama (Nihon Univ.) 17:00~17:10 Break 17:10~17:50 Special Lecture I (Chairman: Hiroshi Ueda) Hitoshi Okamura (Kyoto Univ.)




March 14th, 9:00~ (Bauduin Hall) 9:00 ~ 10:50 Lectures V-IX (Chairman: Hiroshi Ueda)

9:00~ 9:20 Lectures V Tetsuro Torisu (Nagasaki Univ.)

9:20~ 9:50 Lectures VI Koichi Noguchi (Hyogo Col. of Med.)

9:50~10:20 Lectures VII Kazuhide Inoue (Kyushu Univ.)

10:20~10:50 Lectures VIII Seiji Ito (Kansai Med. Univ.)

10:50~11:05 Coffee Break

11:05~12:15 Lectures IX, X (Chairman: Kazuo Toda)

11:05~11:35 Lectures IX Tatsuro Yamamoto (Kumamoto Univ.)

11:35~12:15 Lecture X Eija Kalso (Helsinki Univ. Cent. Hosp.)

12:15~13:40 Lunch

13:40~14:20 Special Lecture II (Chairman: Hiroshi Ueda)

Hideyuki Okano (Keio Univ.)

14:20~15:20 Lecture XI, XII (Chairman: Makoto Inoue)

14:20~14:40 Lecture XI Yasuhito Uezono

(Nagasaki Univ., National Cancer Center)

14:40~15:20 Lecture XII Brigitte L. Kieffer (IGBMC)

15:20 Closing Hiroshi Ueda

pain control and research 2009 in nagasaki japanvi koichi noguchi: molecular mechanism of...

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