porfirinas pigmentos biliares y nucleotidos
DESCRIPTION
formacion del grupo hem de la hemoglobinaTRANSCRIPT
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PORFIRIN
AS Y
PIGMENTOS B
ILIARES
L e o n a r d o H o m a r R a m o s
E r i c k S á n c h e z P u e n t e
K e l l y Te h e r á n R o d r í g u e z
K e y l a Va l e n c i a C a s t e l l a r
S i n d r y Ve l á s q u e z E c h a v e z
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IMPORTA
NCIA B
IOM
EDICA
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METALOPORFIRINAS Y HEMOPROTEINAS
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EL HEM SE SINTETIZA A PARTIR DE SUCCINIL- COA Y GLICINA
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EL HEM SE SINTETIZA A TRAVÉS DE LA ENZIMA ALA SINTASA
ALAS1
ALAS2
ALASINTAS
A
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ESPECTROFOTOMETRIA
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Tipos de Porfirias
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BILIRRUBINA
• Poco hidrosoluble.• No polar.• Secretada hacia la Bilis.
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PRODUCCIÓN DE BILIRRUBINA
• Catabolismo del HEM• ENZIMA iniciadora Hem
oxigenasa.• Resultado tetrapirrol lineal.
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TRANSFERENCIA DE BILIRRUBINA HACIA LA BILIS
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ENFERMEDADES POR CANTIDADES ALTAS DE
BILIRRUBINA
ICTERIA FISIOLOGICA NEONATAL
SINDROME DE CRIGLER-NAJJAR
TIPO 1
SINDROME DE CRIGLER-NAJJAR
TIPO II
SINDROME DE GILBERT
HIPERBILIRRUBINEMIA TOXICA
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OBSTRUCCION DEL ARBOL BILIAR
SINDROMR DE DUBIN- JOHNSON
SINDROME ROTOR
Hiperbilirrubina
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UROBILINOGENO Y LA BILIRRUBINA EN LA ORINA
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NUCLEÓTI
DOS
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PURINAS Y PIRIMIDINAS• Donadores y aceptores de G.
fosforilo.• Compuestos heterocíclicos.
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NUCLEÓSIDOS • Base nitrogenada + Azúcar.
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• Ribonucleosidos: D-Ribosa
(Enlaces Beta N- glucosídico)• Desoxirribonucleósido: 2-Desoxi-
D-Ribosa
(Enlaces Beta N- glucosídico)
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• Purinas: N9• Pirimidinas: N1
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MONONUCLEÓTIDOS• Nucleósidos con G. fosforilo
esterificado a un G. hidroxilo del azúcar.
(Enlaces anhídridos de ácido)• Forman nucleósidos difosfatos y
trifosfatos.
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BASES NITROGENADAS
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PURIN
AS
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ADENINA
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GUANINA
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P
IRIM
IDIN
AS
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CITOSINA
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URACILO
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TIMINA
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ACIDO DESOXIRRIBONUCLEICO ADN
• Adenina + Guanina + Citosina + Timina
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ACIDO RIBONUCLEICO ARN
• Adenina + Guanina + Citosina + Uracilo
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FUNCIONES FISIOLÓGICAS• ATP• GTP• CTP• GMPC
• AMPC
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CONSIDERACIONES CLÍNICAS• Citarabina: Quimioterapias de
Cáncer.• Azatioprina: Trasplante de
Órganos. • Alopurinol: Hiperuricemia.
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GRACIAS!