7/29/2019 PP Clarithromycin

1/2

PP Clarithromycin

Kelas Macrolides

MoA

Clarithromycin menghambat sintesis protein dengan menempel pada 50s ribosomal

subunits. Aktivitas melawan streptococci danstaphylococci dan spesies lainsepertiB. catarrhalis, L. spp, C. trachomatisandU. urealyticum.Farmakokinetik

Absorption: GI tract (oral).

Distribution:Distribusi luas, ASIMetabolism:Hepatic dikonversi menjadi 14-hydroxyclarithromycin dan metabolitlain

Excretion:via bile menjadi feses; via the urine (20-30% as unchanged, 10-15% as14-hydroxyclarithromycin and other metabolites).3-4 hr and 5-7 hr (elimination

half-life)

Indikasi

danDosis OralSusceptible infections

Adult:250 mg bid increased to 500 mg bid for severe infections if necessary for 7-14 days.

Child:7.5 mg/kg bid for 5-10 days.

Oral

Respiratory tract infections

Adult:250 mg bid increased to 500 mg bid for severe infections if necessary for 7-14 days.

Child:7.5 mg/kg bid for 5-10 days.

OralSkin and soft tissue infections

Adult:250 mg bid increased to 500 mg bid for severe infections if necessary for 7-14 days.

Child:7.5 mg/kg bid for 5-10 days.

Oral

Mycobacterium avium complex infectionsAdult:500 mg bid in combination with other antimycobacterials.Child:7.5 mg/kg bid; to be used with other antimycobacterials. May increase doseto 15 mg/kg (max: 500 mg) bid.

OralLeprosyAdult:500 mg daily as part of an alternative multidrug therapy.

Oral

Eradication of H. pylori associated withpeptic ulcerdiseaseAdult:500 mg bid; given in combination with another antibacterial and either aproton pump inhibitor or H2-receptor antagonist for 7-14 days.

Child:1 yr: 7.5 mg/kg bid; may be given with another antibacterial and a proton

http://mims.com/Indonesia/diagnoses/info/1362http://mims.com/Indonesia/diagnoses/info/1756http://mims.com/Indonesia/diagnoses/info/1756http://mims.com/Indonesia/diagnoses/info/1362

7/29/2019 PP Clarithromycin

2/2

pump inhibitor for 7 days.

Intravenous

Respiratory tract infections

Adult:500 mg bid for 2-5 days. Dose to be infused over 60 minutes in a 0.2%solution; revert to oral therapy whenever possible.

Child:1 mth-12 yr: 7.5 mg/kg every 12 hr. Dose to be given via infusion intoproximal vein.

Intravenous

Skin and soft tissue infectionsAdult:500 mg bid for 2-5 days. Dose to be infused over 60 minutes in a 0.2%solution; revert to oral therapy whenever possible.

Child:1 mth-12 yr: 7.5 mg/kg every 12 hr. Dose to be given via infusion intoproximal vein.

Intravenous

Susceptible infections

Adult:500 mg bid for 2-5 days. Dose to be infused over 60 minutes in a 0.2%solution; revert to oral therapy whenever possible.

Child:1 mth-12 yr: 7.5 mg/kg every 12 hr. Dose to be given via infusion intoproximal vein.

Kontraindikasi

Hypersensitivity. Patients receiving terfenadine, astemizole, pimozide, cisapride and

ergot derivatives. Pregnancy; history of acute porphyria.

Side Effect

GI upset, glossitis, stomatitis, altered taste; headache, dizziness, hallucinations,

insomnia, other CNS effects; rash; hepatic dysfunction,

Potentially Fatal: Pseudomembranous colitis, anaphylaxis, Stevens-Johnsonsyndrome.

Drug Interaction

May potentiate oral anticoagulant action. May elevate serum-digoxin concentration.

Potentially Fatal:Increases plasma concentrationsofterfenadineorastemizole. Increases the risk of ventricular arrhythmias inpatients with preexisting cardiac diseases.

Special Precaution Renal and hepatic impairment; macrolide cross-resistance; lactation, children

Sumber : mims.com

http://mims.com/Indonesia/interaction/Search/clarithromycin%7Cterfenadinehttp://mims.com/Indonesia/interaction/Search/clarithromycin%7Castemizolehttp://mims.com/Indonesia/interaction/Search/clarithromycin%7Castemizolehttp://mims.com/Indonesia/interaction/Search/clarithromycin%7Cterfenadinehttp://mims.com/Indonesia/interaction/Search/clarithromycin%7Castemizole