previo 2. manejo, sexado y marcado de animales de laboratorio

8/18/2019 Previo 2. Manejo, Sexado y Marcado de Animales de Laboratorio

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CUESTIONARIO PREVIO

UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICOFACULTAD DE ESTUDIOS SUPERIORES CUAUTITLAN

DEPARTAMENTO DE CIENCIAS BIOLÓGICASSECCIÓN BIOQUÍMICA Y FARMACOLOGÍA HUMANA

LABORATORIO DE FARMACOLOGÍA

Previo No. 2 MANEJO, SEXADO, MARCADO, DISTRIBUCIÓN YVÍAS DE ADMINISTRACIÓN EN ANIMALES DE LABORATORIO.

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'"(#r1% $ro(e&i)ie%!o" -'e re&' (#% el Go i%0li+i&o # lo" #%i)#le".Se re(5# # (#!e+/ri(#)e%!e ('#l-'ier # '"o o #(!o &e (r'el& (o% lo" #%i)#le"

* "e le" $ro('r#r1% l#" )e3ore" (o%&i(io%e" &e vi, ri%&1%&ole" #l 0i%#l &e l#)i")# '%# )'er!e r1$i * "i% &olor.

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Lo" r#!o%e" "e #lo3#% e% (#3#" o 3#'l#" e"$e(i#l)e%!e &i"eG#" $#r# 0#(ili!#r "'ie%e"!#r, $'e&e% "er &e )e!#l o &e $l1"!i(o $oli$ro$ile%o, $oli(#r o%#!o,

$olie"!ire%o * $ol*"'l0#%o , $rovi"!#" &e !#$#" &e #(ero i%o:i le (o% o "i% 0il!ro.El $olie"!ire%o e" !r#%"$#re%!e * re"i"!e #l #'!o(l#v#&o * # l# )#*or4# &e&e"i%0e(!#%!e". El $olie"!ire%o * el $oli$ro$ile%o %o re"i"!e% !e)$er#!'r# elev#".L# #l!'r# &e l#" $#re&e" &e l# (#3# %o &e e "er )e%or &e 72,@ ().De e !e%er l#" "i+'ie%!e" (#r#(!er4"!i(#"68Pro$or(io%#r e"$#(io #&e('#&o, "er (err#&o, "e+'ro * $ro!e+erlo &e l#"#)e%# #" e:!er%#".8 Ser #&e('#&o e% ve%!il#(i/%.8 Ser re"i"!e%!e #l l#v#&o, &e"i%0e((i/% * e"!erili #(i/% 0re('e%!e. 8Per)i!ir l# o "erv#(i/% &el #%i)#l.8 Te%er $i"o" * $#re&e" 01(ile" &e li)$i#r "'$er0i(ie" li"#" * (o% !#$# re)ovi le&e re3#" o $er0or#.8 M#%!e%er"e e% 'e%#" (o%&i(io%e" &e '"o.8H#(ili!#r el #((e"o &e lo" #%i)#le" #l #+'# * #li)e%!o.8No $re"e%!#r or&e" (or!#%!e" o $ro*e((io%e" -'e $'e% (#'"#r le"io%e"

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3#'l#" o (#3#" &e e "er #$ro$i#&o $or e3e)$lo, e% el (#"o &e r#!o%e" #&'l!o", "ere-'iere '%# "'$er0i(ie )4%i)# &e ()2 $or #%i)#l. El re-'eri)ie%!o )4%i)o e"-'e el #%i)#l &i"$o%+# &e e"$#(io "'0i(ie%!e $#r# )over"e * $#r# e:$re"#r l#"$o"!'r#" %or)#le" &e (o%&'(!# * "o(i# ili&, &e e !e%er 01(il #((e"o #l #+'# *#li)e%!o * &e e !e%er '% 1re# "'0i(ie%!e (o% )#!eri#l &e le(5o li)$io * "i%o "!1('lo" $#r# )over"e * &e"(#%"#r. E% l# "i+'ie%!e !# l# "e )'e"!r# l#"re(o)e%(io%e" &el e"$#(io #"i+%#&o # roe&ore" #lo3#&o" e% +r'$o" "i "e#lo3#% i%&ivi&'#l)e%!e o e:(e&e% lo" $e"o" li"!#&o", $o&r4#% re-'erir &e )1"e"$#(io, &e #('er&o (o% el (ri!erio $ro0e"io%#l * &e e:$erie%(i#.L&/7o o /a3aLo" le(5o" "er1% &e )#!eri#l # "or e%!e !#l (o)o l# vir'!# &e )#&er#, l# (oro%!#)oli &el )#4 )#rlo , e!(. li re" &e $olvillo, #ler+e%o" * "'"!#%(i#" !/:i(#".De e% "er e"!erili # le". L# vir'!# )1" #&e('# e" l# &e $i%o l#%(o, "e+'i$or l# &e !or%illo. Se &e e !e%er e"$e(i0i(#(io%e" &e (#li& &e l# vir'!# $#r# "'#&-'i"i(i/%, !#le" (o)o6


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8 No "er %o(ivo. 8C#$#(i& &e # "or(i/% 8 No "e re(o)ie% el '"o &e vir'!#$ro(e&e%!e &e (e&ro o (#o #A$%a & b&b) aEl #+'# &e e "er $o!# le * "')i%i"!r#r"e li re)e%!e &'r#%!e !o l# vi &el#%i)#l, $'e&e "er e% 0r#"(o" e e&ero" &e vi&rio o &e $oli(#r o%#!o. El #+'#

&e e "er #(i&i0i(#, e"!erili # )e&i#%!e #'!o(l#ve o $or ) !o&o &e 0il!r#(i/%. Ali)e%!o6 &ie!#" * Re-'eri)ie%!o" El #li)e%!o e" el )#!eri#l $ri)#rio # $#r!ir &el('#l "e v#% # 0or)#r * re%ov#r lo" !e3i&o" * e"!r'(!'r#" (or$or#le", !#%!o l#"%'ev#" (o)o l#" *# e:i"!e%!e", -'e &e e% "er re)$l# #" &e i&o #l &e"+#"!e.L#%'!ri(i/% e" &e!er)i%#%!e e% lo" e"!#&o" "'(e"ivo" &e (re(i)ie%!o * $ro&'((i/% &e lo"#%i)#le", &e #54 -'e 5#*# #li)e%!o" e"$e(40i(o" $#r# (# e"$e(ie * 5#"!# $#r# (#e!#$# &e "' vi. L'e+o &e "' #&-'i"i(i/%, "e &e e !e%er ('i&o e% el !r#%"$or!e,#l)#(e%#)ie%!o * )#%i$'l#(i/% &el #li)e%!o $#r# re&'(ir #l )4%i)o l# i%!ro&'((i/% &ee%0er)e&e", $#r1"i!o" * ve(!ore" $o!e%(i#le" &e e%0er)e&e" $or e3e)$lo, i%"e(!o" *o!r#" $l#+#" * (o%!#)i%#%!e" -'4)i(o". Se &e e (o%!#r (o% '% $ro(e&i)ie%!o $#r# l##&-'i"i(i/% &e #li)e%!o * lo" re-'i"i!o" -'e e"!e &e e re'%ir, !#le" (o)o6

8Co)$o"i(i/%, -'e &e er1 (' rir l#" %e(e"i&e" &e (re(i)ie%!o, +e"!#(i/%,l#(!#%(i# * )#%!e%i)ie%!o &el r#!/%. 8De e "er #+r# le #l $#l#r * &i+e"!i le8Te%er 0e(5# &e el# or#(i/% * (#&'(i&.8Cer!i0i(#&o &e #%1li"i" -'4)i(o $ro:i)#l * )i(ro iol/+i(o $or (# lo!e.8E"!#r li re &e 5#ri%# &e $e"(#&o, #&i!ivo", &ro+#", 5or)o%#", #%!i i/!i(o",$e"!i(i" * (o%!#)i%#%!e" $#!/+e%o".8El #li)e%!o e% 0or)# &e $elle! &e e !e%er l# (o%"i"!e%(i# re-'eri, $#r# evi!#r $er&i &el #li)e%!o * el #%i)#l $'e (o%"')irlo.

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El )#(ro#) ie%!e e" el e"$#(io i%)e&i#!o #l )i(ro#) ie%!e * e" l# "#l# &e#lo3#)ie%!o e% "' 1) i!o +e%er#l. L# #l!er#(i/% &e lo" 0#(!ore" &el )#(ro#) ie%!e$ro&'(ir1 (#) io" e% el )o&elo #%i)#l * (o% ello, l# )o&i0i(#(i/% &el !i$o &ere"$'e"!#, * #')e%!o &e l# v#ri# ili& &e lo" re"'l!#&o" e%!re o &e%!ro &e lo"l# or#!orio" &e e:$eri)e%!#(i/%

A)r& ; .&14)la/)01Lo" #) ie%!e" &e"!i%#&o" # l# $ro&'((i/% &e #%i)#le", e% "' i%!erior, &e e%$o"eer ve%!il#(i/% (o% $re"i/% $o"i!iv# &e #ire re"$e(!o # lo" $#"illo" o 1re#"e:!eriore", )#%!e%ie%&o l#" +r#&ie%!e" &e $re"i/%, &e !#l 0or)# -'e "e evi!# el

i%+re"o &e $#!/+e%o" &e"&e el e:!erior. E% (#"o &e $o"eer '% io!erio &e &o le$#"illo (o% lo(#le" (e%!r#le" (ir('l#(i/% li)$i# * "'(i# , l# +r#&ie%!e &e $re"i/%"er1 &el li)$io 5#(i# el "'(io. L# ve%!il#(i/% e" i)$or!#%!e $#r# (o%!rol#r l#5')e&, (#lor, +#"e" !/:i(o". Se &e e +e%er#r e%!re 7> # 2 re(#) io" &e #ire 5or#. Lo" "i"!e)#" &e #ire #(o%&i(io%#&o o ve%!il#(i/% %o $o&r1% "er (o)$#r!i&o"(o% o!r#" 1re#", "er1% e:(l'"ivo" $#r# el "e(!or io!erio * (o% 0#(!ore" (o%!rol#&o"&e !e)$er#!'r# * 5')e&.


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T&3!&ra4%ra ; 7%3& a r&la4).aL#" e:i+e%(i#" &e !e)$er#!'r# $#r# r#!o%e" "o% &e 2 # 2> KC * l# 5')e&rel#!iv# #) ie%!#l e%!re < * @ . L#" (o%&i(io%e" #) ie%!#le" e% -'e "e (r4#% *e:$eri)e%!#% lo" #%i)#le" i%0l'*e% &e(i"iv#)e%!e e% l#" re"$'e"!#" # lo"&i0ere%!e" !r#!#)ie%!o". Si "e re-'iere re"$'e"!#" e"!#%ri #", l#" (o%&i(io%e"

e% -'e "e )#%!ie%e% lo" #%i)#le" &e e% "er 0i3#".I14&1() a & l%' ; 4)!o & )l%3)1a/)01Lo" #) ie%!e" &e (ri#% # &e e% (o%!#r (o% l# l' #r!i0i(i#l, $rovi"!# &e l1)$#r#"0l'ore"(e%!e" !i$o l' &4#, (o% i%(i&e%(i# o li('#, (o% '%# il')i%#(i/% )1:i)# &e;2; l': # '% )e!ro &el $i"o &e 0or)# !#l, -'e !o" l#" 3#'l#",i%&e$e%&ie%!e)e%!e &e "' ' i(#(i/%, re(i #% i%!e%"i&e" "i)il#re" &e l' . L#il')i%#(i/% &e e &i"!ri 'ir"e #&e('#)e%!e # !r#v " &e l# "#l# &e #lo3#)ie%!o *"er lo "'0i(ie%!e $#r# l#" $r1(!i(#" &e )#%!e%i)ie%!o, i%"$e((i/% * ie%e"!#r &ee"!o", "i% (#'"#rle" "i+%o" (l4%i(o" # lo" #%i)#le". T#) i % &e e $ro$or(io%#r (o%&i(io%e" "e+'r#" &e !r# #3o $#r# el $er"o%#l. L# il')i%#(i/% e" i)$or!#%!e

$#r# l# re+'l#(i/% &el (i(lo e"!r#l * re$ro&'(!ivo. Se re(o)ie% 72 5or#" l' 72 5or#"o"('ri&, lo ('#l "e $ro+r#)# (o% '% relo3 !e)$ori #&or.

R%) oLo" r#!o%e" "o% )'* "e%"i le" #l r'i&o * $'e&e% $er(i ir 0re('e%(i#" &e "o%i&o -'e "o%i%#'&i le" $#r# el "er 5')#%o, $or lo -'e el $er"o%#l &e e !r#!#r &e )i%i)i #r l#+e%er#(i/% &e r'i&o i%%e(e"#rio. El r'i&o e:(e"ivo e i%!er)i!e%!e "e $'e&e )i%i)i #r(#$#(i!#%&o #l $er"o%#l e% )o&o" #l!er%#!ivo" # l#" $r1(!i(#" -'e $ro&'(e% r'i&o. Lo"r#&io", (el'l#re", #l#r)#" * o!ro" +e%er#&ore" &e "o%i&o, #'% (o% #'ri('l#re" o#'&40o%o", %o &e e% '"#r"e e% l#" "#l#" &e #lo3#)ie%!o &e #%i)#le". Se $er)i!e '% %ivel)1:i)o &e r'i&o &e > &e(i ele", "i e"!o" "o% )#*ore" !ie%e e0e(!o" %o(ivo" (o)o e"!r "* $ro le)#" &e 0er!ili&.

OlorEl olor e" o!ro 0#(!or -'e #0e(!# #l r#!/%, e" $or ello -'e %o "e &e e '!ili #r &e"i%0e(!#%!e"-'e e)#%e% olore", -'e "e#% irri!#%!e" * )'(5o )e%o" &e"o&ori #%!e", &e%!ro &e lo"#) ie%!e" &el io!erio. L# $er(e$(i/% &e #)o%i#(o e% el #) ie%!e e" '% i%&i(#&or &e"#!'r#(i/% &el le(5o, $or lo -'e "e re(o)ie% !e%er $ro+r#)#" &e (#) io &e le(5o"e+ % l# $o l#(i/% -'e "e )#%e3e. Por e3e)$lo, "e (o%o(e -'e el 5o) re e" (#$# &e$er(i ir 7 $$) &e #)o%i#(o &el #) ie%!e &el r#!/% * "!e $'e&e $er(i ir &e"&e 2> $$)&e #)o%i#(o.

:6 Cla()9)/a la( .#a( & a 3)1)(4ra/)01 & lo( 9 r3a/o( ; a1o4a &@&3!lo(& /a a %1a & &lla( & a/%&r o a

a= S)4)o & a!l)/a/)01

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b= S)4)o !or o1 & !a(aE14&ral"Or#l Re(!#l "' li%+'#lPar&14al"I%!r# o('l#r, !/$i(#, i%!r#!e(#l, i%!r#ve%!ri('l#r "' ('!1%e#/= Ra!) &' & a//)01E14&ral" I17ala4or)o(S'"$e%"i/%, 3#r# e, eli:ir, $olvo, (#$"'l#, !# le!#

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:6 D&(/r)b& lo( &.&14o( 4&r &4#l)/o!or .#a )17ala4or)a

Se $ro&'(e '% e"!#&o &e i%(o%"(ie%(i# )e&i#%!e l# #&)i%i"!r#(i/% &e !er e!4li(o#%e"! "i(o

Pri)ero &e e)o" "# e" -'e l# #%e"!e"i# "e &ivi&e e% 0#"e" -'e i%(l'*e% #l $#ro'l #r.


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E4a!a III6 #%e"!e"i# -'ir r+i(#, -'e "e "' &ivi&4# e% ('#!ro $l#%o", (o% $ro+re"iv#$ r&i &e (o%(ie%(i# * &e re0le3o", re+'l#ri #(i/% &e l# re"$ir#(i/% * &e$re"i/%(re(ie%!e &e e"!# #(!ivi& * rel#3#(i/% )'"('l#r. L# )#*or $#r!e &e l#"i%!erve%(io%e" -'ir r+i(#" &e 4#% re#li #r"e e% lo" $l#%o" 28; &e e"!# e!#$#.

E4a!a IV6 $#r1li"i" 'l #r, (o% &e$re"i/% (e%!r#l +e%er#li # -'e #0e(!# # lo"(e%!ro" 'l #re" 5#"!# el $#ro re"$ir#!orio.

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