For users of

Differin® Gel 0.1%

Read before you use the drug.

Continuity is important in acne treatment.Continue the treatment so that your skin will become less likely to get pimples.

　　/　　 （　　）　　 ：Your next scheduled hospital visit

Distributor2019年12月作成A1219AY-NJ5041605

You should regularly wash your face twice daily, in the morning and in the evening. It is important for you to wash your face softly without scrubbing it strongly in order not to pop pimples. When you choose a facial cleanser, choose a non-comedogenic product (a product confirmed to be less likely to cause pimples) or a hypoallergenic one.

step1 step2 step3

Watch the video to see how to wash your face. Useful information

Do you know how to wash your face in the correct way?

Wash your face by covering it with spongy foam.

Rinse away the foam with warm water so that your entire face is cleansed.

Pat your face dry with a soft towel.

Medical institution name

How to apply Differin Gel

How a pimple forms

Website providing information about acne

Acne treatment-assisting application

1 2

Expected changes from continuous treatment

Start of the treatment At 3 months At ≥ 1 year

＊The course of treatment differs for each patient.

Period where aggressive treatment is required for currently existing pimples

Period where recurrence should be prevented to maintain a good condition

RecurrenceRecurrence

Continuity is important in acne treatment.Keep using the drug for the first 3 months.If you stop the treatment halfway, you may repeatedly get pimples.Continuous treatment with patience will allow you to have a chance to achieve the skin that is less likely to have pimples.

Large

Small

Continuity is important in acne treatment. Acne is a disease that develops in a pore.

Number of pimples

Continuity is the father

of success.

It is important for you to continue the treatment in

order to prevent the recurrence of acne.

Organ which secretes sebum (sebaceous gland)

Cutibacterium acnes

Normal pore

Photographs provided by Dr. Yoichi Nishimura, director of the Nishimura Dermatology Clinic and Dr. Hiroko Ichimiya, director of the Ichimiya Dermatology Clinic

1　Origin of a pimple 　 (microcomedo)

2　Whitehead/blackhead 　 pimple (comedo)

3　Red pimple

4　Purulent pimple

5　Postinflammatory redness/acne scar

What is happening in the pore?

Sebum secretion is increased by the effect of sex hormones or by other factors. The increased sebum starts to accumulate in a pore. Microcomedo that cannot be seen from the outside is present around a visible pimple.

This is a condition where sebum cannot leave through the pore because of clogging. You can feel a textured surface when you touch a whitehead/blackhead pimple. A whitehead/black-head pimple looks slightly elevated.

Cutibacterium acnes, which loves eating sebum, proliferates in the pore.Cutibacterium acnes attracts an inflammatory substance which causes inflammation. The color of the pimple is changed to red by inflammation.

If inflammation is further aggravated, the wall of the expanded pore gets ruptured. Inflammation spreads to the surrounding tissue and causes yellow pus.

After inflammation subsides, redness may remain in some cases.This redness usually disappears over time.On the other hand, acne scars with bumps and dips will less frequently resolve once they form.

Pimples develop not only on the face but also on the chest and back. If you have any annoying pimples, do not hesitate to consult your doctor.

Acne scarPostinflammatory redness

Proliferative Cutibacterium acnes

Substance that causes inflammation

2 3

1 2

Expected changes from continuous treatment

Start of the treatment At 3 months At ≥ 1 year

＊The course of treatment differs for each patient.

Period where aggressive treatment is required for currently existing pimples

Period where recurrence should be prevented to maintain a good condition

RecurrenceRecurrence

Continuity is important in acne treatment.Keep using the drug for the first 3 months.If you stop the treatment halfway, you may repeatedly get pimples.Continuous treatment with patience will allow you to have a chance to achieve the skin that is less likely to have pimples.

Large

Small

Continuity is important in acne treatment. Acne is a disease that develops in a pore.

Number of pimples

Continuity is the father

of success.

It is important for you to continue the treatment in

order to prevent the recurrence of acne.

Organ which secretes sebum (sebaceous gland)

Cutibacterium acnes

Normal pore

Photographs provided by Dr. Yoichi Nishimura, director of the Nishimura Dermatology Clinic and Dr. Hiroko Ichimiya, director of the Ichimiya Dermatology Clinic

1　Origin of a pimple 　 (microcomedo)

2　Whitehead/blackhead 　 pimple (comedo)

3　Red pimple

4　Purulent pimple

5　Postinflammatory redness/acne scar

What is happening in the pore?

Sebum secretion is increased by the effect of sex hormones or by other factors. The increased sebum starts to accumulate in a pore. Microcomedo that cannot be seen from the outside is present around a visible pimple.

This is a condition where sebum cannot leave through the pore because of clogging. You can feel a textured surface when you touch a whitehead/blackhead pimple. A whitehead/black-head pimple looks slightly elevated.

Cutibacterium acnes, which loves eating sebum, proliferates in the pore.Cutibacterium acnes attracts an inflammatory substance which causes inflammation. The color of the pimple is changed to red by inflammation.

If inflammation is further aggravated, the wall of the expanded pore gets ruptured. Inflammation spreads to the surrounding tissue and causes yellow pus.

After inflammation subsides, redness may remain in some cases.This redness usually disappears over time.On the other hand, acne scars with bumps and dips will less frequently resolve once they form.

Pimples develop not only on the face but also on the chest and back. If you have any annoying pimples, do not hesitate to consult your doctor.

Acne scarPostinflammatory redness

Proliferative Cutibacterium acnes

Substance that causes inflammation

2 3

Many patients experience irritation soon after they start to use Differin Gel. However, such irritation gradually subsides. If you have any annoying signs or symptoms of irritation, do not hesitate to consult your doctor/pharmacist as soon as possible.

Irritative symptoms such as redness, irritation, peeling of the skin, and skin dryness frequently develop within 2 weeks after you start to use Differin Gel. The irritative symptoms are temporary and gradually subside. If you have any annoying irritative signs or symptoms, do not hesitate to consult your doctor/pharmacist as soon as possible.

3 4 You may experience irritation soon after you start to use Differin Gel.

Side effects of Differin Gel

Photographs provided by Dr. Hiroko Ichimiya, director of the Ichimiya Dermatology Clinic

See the section “For patients who have annoying irritation and/or skin dryness” on Page 6.

When does irritation develop? Measures you can take against irritation and skin dryness

Sun

7

14

21

28

Mon

1

8

15

22

29

Tue

2

9

16

23

30

Wed

3

10

17

24

31

Thu

4

11

18

25

Fri

5

12

19

26

Sat

6

13

20

27

START!

Be careful about the signs and

symptoms in the first few weeks after you start to use the drug.

Differin Gel controls the keratinization process* of the skin to alleviate clogged pores.It cleans clogged pores, the cause of repeated pimples, and is effective against whitehead pimples and red pimples.

Differin Gel controls keratinization of the skin to alleviate

clogged pores.

Figure of a pore with a red pimple

Cutibacterium acnes

Substance that causes inflammation

Differin Gel is a drug used to alleviate clogged pores.

How Differin Gel works

＊Process from birth to cuticle of the celles that from the skin surface

Irritative symptoms will gradually subside in most cases. If you have any annoying signs or symptoms of irritation, do not hesitate to consult your doctor.

Redness/irritation

Irritative symptoms

Peeling of the skin/skin dryness

4 5

Many patients experience irritation soon after they start to use Differin Gel. However, such irritation gradually subsides. If you have any annoying signs or symptoms of irritation, do not hesitate to consult your doctor/pharmacist as soon as possible.

Irritative symptoms such as redness, irritation, peeling of the skin, and skin dryness frequently develop within 2 weeks after you start to use Differin Gel. The irritative symptoms are temporary and gradually subside. If you have any annoying irritative signs or symptoms, do not hesitate to consult your doctor/pharmacist as soon as possible.

3 4 You may experience irritation soon after you start to use Differin Gel.

Side effects of Differin Gel

Photographs provided by Dr. Hiroko Ichimiya, director of the Ichimiya Dermatology Clinic

See the section “For patients who have annoying irritation and/or skin dryness” on Page 6.

When does irritation develop? Measures you can take against irritation and skin dryness

Sun

7

14

21

28

Mon

1

8

15

22

29

Tue

2

9

16

23

30

Wed

3

10

17

24

31

Thu

4

11

18

25

Fri

5

12

19

26

Sat

6

13

20

27

START!

Be careful about the signs and

symptoms in the first few weeks after you start to use the drug.

Differin Gel controls the keratinization process* of the skin to alleviate clogged pores.It cleans clogged pores, the cause of repeated pimples, and is effective against whitehead pimples and red pimples.

Differin Gel controls keratinization of the skin to alleviate

clogged pores.

Figure of a pore with a red pimple

Cutibacterium acnes

Substance that causes inflammation

Differin Gel is a drug used to alleviate clogged pores.

How Differin Gel works

＊Process from birth to cuticle of the celles that from the skin surface

Irritative symptoms will gradually subside in most cases. If you have any annoying signs or symptoms of irritation, do not hesitate to consult your doctor.

Redness/irritation

Irritative symptoms

Peeling of the skin/skin dryness

4 5

You need to store the drug at room temperature (between 1℃ and 30℃).

How widely you should apply the drugYou are recommended to apply the drug by spreading it around pimples in consideration of the presence of microcomedones*1. Once you get used to the irritation, try to apply 1 FTU*2 of the drug to the entire face.

Instructions from the doctor

Protect your skin from sunburn

Store the drug at room temperature

5

For patients who have annoying irritation and/or skin dryness

Precautions for use of Differin Gel

Confirm how and where to apply the drug.

1 FTU

Use the drug according to the instructions from your doctor/pharmacist.

You will be more sensitive to irritation while you are using Differin Gel. You need to protect your skin from sunburn.

For pregnant or breastfeeding patients

You must not use Differin Gel if you are or may be pregnant.

＊After Differin Gel of a dose greater than that used in acne treatment was administered to pregnant laboratory animals, abnormalities of the bones/organs were noted in some of their children.

You are expected to avoid using Differin Gel while you are breastfeed-ing. If you necessarily use the drug, stop breastfeeding.

Washyourface

Applysunscreen （　　　　）Apply

makeup

ApplyDifferin

Go tobed

Morning

Night

If you haveannoying skindryness

Moisturizeyourskin

Apply yourconcomitantmedication(s)

Apply yourconcomitantmedication(s)

Apply yourconcomitantmedication(s)

Apply yourconcomitantmedication(s)

How to app ly D i f f e r in Ge l

Softly apply the drug to the affected areas without rubbing. Avoid applying the drug to the eyes, lips, mucosa, and wounds. Wash your hands after you finish the treatment.

Moisturizing the skinIf you have annoying skin dryness, you are recommended to moisturize your skin with a non-comedogenic product (a product confirmed to be less likely to cause pimples).

Washing the drug away

If you have irritation, you are recommended to wash the drug away with water.

Apply Differin Gel once daily after washing your face.

＊1 Microcomedo The origin of a pimple that cannot be seen 　　 from the outside. See Page 3 for the details.

＊2 FTU(f ingertip unit) The length from the tip to the first joint of the index finger

One FTU (approximately 0.5 g) is a guide for the amount apply to the entire face.

Eyes Acne wound

Once daily

You can see an example of how to apply the drug correctly in the video. ＞＞＞

6 7

You need to store the drug at room temperature (between 1℃ and 30℃).

How widely you should apply the drugYou are recommended to apply the drug by spreading it around pimples in consideration of the presence of microcomedones*1. Once you get used to the irritation, try to apply 1 FTU*2 of the drug to the entire face.

Instructions from the doctor

Protect your skin from sunburn

Store the drug at room temperature

5

For patients who have annoying irritation and/or skin dryness

Precautions for use of Differin Gel

Confirm how and where to apply the drug.

1 FTU

Use the drug according to the instructions from your doctor/pharmacist.

You will be more sensitive to irritation while you are using Differin Gel. You need to protect your skin from sunburn.

For pregnant or breastfeeding patients

You must not use Differin Gel if you are or may be pregnant.

＊After Differin Gel of a dose greater than that used in acne treatment was administered to pregnant laboratory animals, abnormalities of the bones/organs were noted in some of their children.

You are expected to avoid using Differin Gel while you are breastfeed-ing. If you necessarily use the drug, stop breastfeeding.

Washyourface

Applysunscreen （　　　　）Apply

makeup

ApplyDifferin

Go tobed

Morning

Night

If you haveannoying skindryness

Moisturizeyourskin

Apply yourconcomitantmedication(s)

Apply yourconcomitantmedication(s)

Apply yourconcomitantmedication(s)

Apply yourconcomitantmedication(s)

How to app ly D i f f e r in Ge l

Softly apply the drug to the affected areas without rubbing. Avoid applying the drug to the eyes, lips, mucosa, and wounds. Wash your hands after you finish the treatment.

Moisturizing the skinIf you have annoying skin dryness, you are recommended to moisturize your skin with a non-comedogenic product (a product confirmed to be less likely to cause pimples).

Washing the drug away

If you have irritation, you are recommended to wash the drug away with water.

Apply Differin Gel once daily after washing your face.

＊1 Microcomedo The origin of a pimple that cannot be seen 　　 from the outside. See Page 3 for the details.

＊2 FTU(f ingertip unit) The length from the tip to the first joint of the index finger

One FTU (approximately 0.5 g) is a guide for the amount apply to the entire face.

Eyes Acne wound

Once daily

You can see an example of how to apply the drug correctly in the video. ＞＞＞

6 7

For users of

Differin® Gel 0.1%

Read before you use the drug.

Continuity is important in acne treatment.Continue the treatment so that your skin will become less likely to get pimples.

　　/　　 （　　）　　 ：Your next scheduled hospital visit

Distributor2019年12月作成A1219AY-NJ5041605

You should regularly wash your face twice daily, in the morning and in the evening. It is important for you to wash your face softly without scrubbing it strongly in order not to pop pimples. When you choose a facial cleanser, choose a non-comedogenic product (a product confirmed to be less likely to cause pimples) or a hypoallergenic one.

step1 step2 step3

Watch the video to see how to wash your face. Useful information

Do you know how to wash your face in the correct way?

Wash your face by covering it with spongy foam.

Rinse away the foam with warm water so that your entire face is cleansed.

Pat your face dry with a soft towel.

Medical institution name

How to apply Differin Gel

How a pimple forms

Website providing information about acne

Acne treatment-assisting application