quanti feron

7/26/2019 Quanti Feron

1/9

PLoS One.2009 Dec 14;4(12):e8257.

IFNgamma response to Mycobacterium

tuberculosis, risk of infection and disease inhousehold contacts of tuberculosis patients

in Colombia.

del Corral H, Par SC, !arn "D,!arn D!, L#$e% L,Henao H!, !ar&ne% ',lla L,

*arrera L+, Or&% *L, a-re% !, !on&e C/,Oendo !C, ran3o L!, ao +,3rre

C, *&a-an&e , *elle /', Doo 6, !ea ,raldo !, *rennan P/, oledo /,

rele% !P, oa C, arca L+.

Source

r$o de $de-olo3a, n $l-onar? &erclo $a&en& are a& =3= r@ o>

!?coac&er- &erclo n>ec&on and earl? deae deca&on o>

nd &erclo deae a derale 3oal >or &erclo con&rol.n&er>eronA3a--a releae aa? () n3 $ec>c !. &erclo an&3en $roec&on de&ec&on. dd&onall?, &=e le

+"3a--a $rodced n re$one &o &=ee an&3en -a? =aor 21. o> ncden&

cae. "o 3n>can& d>>erence a >ond e&een $o&


2/9

re$onder &o C+PA10 (H 1.82 95 C 0.79A4.20 $ J 0.1). Hoecan& &rend >or

&erclo del &o e&al= &erclo n>ec&on

$re? &=oe a& =3=e& r@ o> deae. '=e =3= &erclo

ncdence a-on3& c=ldren $$or& ad-n&ra&on o> c=e-o$ro$=?laF &o c=ld con&ac&

re3ardle o> *C or !DL"M

P!CD: P!C27881EE

+ree P!C r&cle

-a3e >ro- &= $lca&on.See all -a3e (4) +ree &eF&

+ro-:

PLoS One. 2009; 4(12): e8257.

Pl=ed onlne 2009 Dece-er 14. do: 10.1E71Kornal.$one.0008257

Co$?r3=&KLceneee& $er-on &o ree

Clc@ on -a3e &o enlar3e
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20011589/?tool=pubmedhttp://www.ncbi.nlm.nih.gov/pmc?term=20011589%5BPMID%5D&report=imagesdocsumhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788133/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788133/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788133/figure/pone-0008257-g001/http://www.ncbi.nlm.nih.gov/pmc/about/copyright.htmlhttp://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20011589/?tool=pubmedhttp://www.ncbi.nlm.nih.gov/pmc?term=20011589%5BPMID%5D&report=imagesdocsumhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788133/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788133/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788133/figure/pone-0008257-g001/http://www.ncbi.nlm.nih.gov/pmc/about/copyright.html


3/9

Figure +

S&d? $ro>le.

HHC J Hoe=old con&ac&, J +"N eleae a?, 'S' J 'ercln S@n 'e&, SP J

orce $o$la&on, C+PA10 J Cl&re +l&ra&e Pro&enA10.

=&&$:KK.nc.nl-.n=.3o


4/9

6e@@[email protected] "oec&ed ndec&on. '=ere>ore, & >cl& &o da3noe L'* n /a$an, =ere *C

ec&, c= a

&ec=ncal or nec&n3 PPD or -earn3 &=e 'S' re$one, &=e nece&? o> a

re&rn &er PPD nec&on, and &=e

oo&er e>>ec& &=ro3= renec&on o> PPD. !ore recen&l?, a ne da3no&c -e&=od &=a& can

oec& n 'S', an&+O" '*A2 (+'A2), =a een deeronA3a--a (+"A3a--a), !& n>ec&on da3noed. Snce

S'A and C+PA10 are aen& >ro- all !. o "'!

ncldn3 !. ae &ran o> "'!, +'A2 no& a>>ec&ed

? $ror *C "'! n>ec&on. !oreo +"A

3a--a can e carred o& ? -ac=ne on &=e neF& da? >ollon3 &=e lood dra, -ore

oec&>ec& n +'A2 a PPD no& nec&ed, nor &o re 'S' decred =ere. +ro- a clncal &ral o> +'A2 n =c= &=e

ec& ere -earA$o&


5/9

=aore, a &=e de $read o> +'A2 &e&n3 n

con&ac& nec& con&er !& n>ec&on, and &=e e>>ec& o>

&rea&-en& >or ' or L'* are no& >ll? nder&ood. '=e e=a +'A2 n n>an& or

c=ldren no& nder&ood e&=er. $ecall? n n>an&, &=e $role- o> &=e lood or &=e +'A2 &e& &=e -aor e. Be are or@n3 on &=ee e &o $roor +'A2 er, and =o$e &=a& e can con&r&e &o ' con&rol.

P!D:

17154047P!ed A ndeFed >or !DL"M

http://www.ncbi.nlm.nih.gov/pubmed/17154047

6e@@[email protected] +e;8(2):101A12.

#he clinical application of 0uantiferon #

12% its usefulness and limitations/.

r&cle n /a$aneeM

Sa&o S,"a3a H.

Source

De$ar&-en& o> !edcal Oncolo3? and --nolo3?, rada&e Sc=ool o> !edcal Scence,"a3o?a C&? nor &=e den&>ca&on o>

&erclo n>ec&on ecae o> & =3= le &l&?. & ell @non &=a& +' &-la&e

$er$=eral lood l?-$=oc?&e n !. &ercloA$ec>c $ro&en, and &=a&

n>ec&on den&>ed ? -earn3 &=e n&er>eronA3a--a releaed. n&er$re&a&on o> +'

rel& &=ere>ore d>>cl& n --no$$reed ec& n =o- &=e >nc&on o>

--noco-$e&en& cell, ncldn3 l?-$=oc?&e, $$reed, -a@n3 & d>>cl& >or &=e- &o

$rodce n&er>eronA3a--a. '=ere a =3= ncdence o> &erclo a-on3 =e-odal?
http://www.ncbi.nlm.nih.gov/pubmed/17154047http://www.ncbi.nlm.nih.gov/pubmed/21404654http://www.ncbi.nlm.nih.gov/pubmed/21404654http://www.ncbi.nlm.nih.gov/pubmed?term=%22Sato%20S%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Nagai%20H%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Nagai%20H%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/17154047http://www.ncbi.nlm.nih.gov/pubmed/21404654http://www.ncbi.nlm.nih.gov/pubmed?term=%22Sato%20S%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Nagai%20H%22%5BAuthor%5D


6/9

$a&en&. & =a een conec&red &=a& &=e e o> $oer>l --no$$reollon3 @dne? &ran$lan&a&on rel& n a =3= r@ o> &erclo. Ho +' rel&

c=an3e --eda&el? >ollon3 @dne? &ran$lan&a&on an eF&re-el? n&ere&n3 e&on. n

recen& ?ear, an ncrean3 n-er o> n&&&on =al >or den&>?n3 =e&=er $a&en& =aec&on e>ore &=e ad-n&ra&on o> an&A'"+ an&odeQ n $ar&clar, -an?r=e-a&od ar&=r& $a&en& -a? =a &= l-&a&on =en

$er>or-n3 +' on --no$$reed $a&en&. & alo -$or&an& &=a& e nder&and &=e

clncal $ara-e&er n>lencn3 +' rel& (c= a l?-$=oc?&e con&). '=e -ord&? ra&e

o> &erclo =3= a-on3 =eal&=care or@er, $ar&clarl? nre. n-er o> &de

=aor -on&orn3 &=e =eal&= o> =eal&=care or@er &ll no& >ll?

nder&ood. n &= ?-$o-, e ll dea&e =o >ar +' can e ed and &=e eF&en& o> &

e>lne nder eFce$&onal crc-&ance. (1) Ho do e -ana3e @dne? &ran$lan&

rec$en& &= la&en& &erclo n>ec&onQ: "or=@o O'O ('ran$lan& Sr3er?, "a3o?aDan ed Cro Ho$&al) & nclear =e&=er an&+O"Aecond 3enera&on (+'A2)

e>l >or da3no&c creenn3 and >ollo $ o> la&en& &erclo n>ec&on (L'*) n

--no$$reed @dne? &ran$lan& (6'F) rec$en&. '=e +'A2 aa? &=a& nclded

re$one &o -&o3en &-la&on a $er>or-ed e>ore and -on&= a>&er 6'F. "on

re$onder a 0 (0) a& aelne, E (E) a& -on&=. e$one &o -&o3en &-la&on a

9.7 RKA 5.E K-L a& aelne &er 6'F ($ J 0.29). +'A

2 a e>l creenn3 &e& >or L'* and ac&

n&ernal !edcne, c= !edcal Sc=ool o> !edcne) 'o de&er-ne &=e $o& L'*

n $a&en& n3 &=e +'A2 &e&, e d> le> a& 0.1 K-l (loer c&o>>

le>ec&ed ? &=e &rea&-en& o> !'G, and &=e ncdence o> nde&er-na&e rel& a lo. '=e

+'A2 a e>l co-$ared &o 'S' e>ore ad-n&ra&on o> '"+ n=&or n $a&en&,

ecae o> $eror $ec>c&? o> +'A2. (E) Clncal $ara-e&er &=a& n>lence &=e

en& 'Acell aa?: Har?@ ("a&onal Ho$&al Or3an%a&on 'o@?o

"a&onal Ho$&al) '=e de&ec&on o> &erclo ('*) n>ec&on n co-$ro-ed =o& een&al >or '* con&rol, & ' cell aa? -3=& e n>lenced ? &=e de3ree o> cellA-eda&ed

--no$$reon. '=e rela&on=$ e&een --noco-$e&ence and $ec>c n&er>eron

(+")A3a--a re$one n =ole lood an&+O"A'* old (+') ncer&an. --neA

rela&ed clncal ndca&or aoca&ed &= &=e de3ree o> an&3enA$ec>c +"A3a--a

$rodc&on ere anal?ed n3 a lar3e --nolo3call?Anelec&ed $o$la&on &= o lood l?-$=oc?&e n '* $a&en& a 3n>can&l?

aoca&ed &= $ec>c +"A3a--a $rodc&on n a lnear re3reon -odel. Sen& 2

+"A3a--a eleae a?, +' and LSPO', $ar&l? de$end on $er$=eral l?-$=oc?&e

con&. & lo l?-$=oc?&e con& cond&on, LSPO' aa? $eror &o =ole lood +'

>or de&ec&n3 &erclo n>ec&on. (4) an&+O" '*A2 a-on3 &a>> n &=e =o$&al

o> "a&onao Ho$&al Or3an%a&on: S- O, C==ro "SHO, 6en@e S!,!aa?o= !"CH, 'o-o-aa 'S*O, &o S'O, Oa- 'O6",


7/9

'a@e= !!O!, 'a@?a 6SB ("a&onal Ho$&al Or3an%a&on !na-A

6?o&o "a&onal Ho$&al)

3)(3OS"%

'o nec&on ra&e o> &erclo a-on3 &a>> or@n3 n &=e =o$&al o>"HO.

M"#&O'%

e&onnare ere en& &o &=e =o$&al and &=e re$one ere anal?%ed.

("S)*#%

-on3 &=e &a>> or@n3 n &=e =o$&al &= &erclo ard, $o&

an&+O" '*A2 a .9, $roale $o&> or@n3 n &=e =o$&al &=o& &erclo ard, $o&>

eearc=


8/9

3ersistently ele4ated # cell interferon5

responses after treatment for latent

tuberculosis infection among health care-orkers in India% a preliminary report

Madhukar 3aiE,1,2T, (a6nish !oshi1,2, Sandeep 'ogra2, 'eepak 7 Mendiratta2, 3ratibha

Narang2,7eertan 'heda4and Shriprakash 7alantri2

T Corre$ondn3 a&=or: !ad=@ar Pa -ad=$aer@ele?.ed

&=or >>la&on

1D $de-olo3?, Sc=ool o> Plc Heal&=, n Cal>orna, *er@ele?,

S

2De$ar&-en& o> !edcne U !croolo3?, !a=a&-a and= n&&&e o> !edcal Scence,

Seorna, San +rancco, S

4Cen&re >or n>ec&o Deae and n&erna&onal Heal&= '=e o?al +ree and n &=e Crea&


9/9

Abstract

ackground

' cellAaed n&er>eronAN (+"AN) releae aa? () are noor la&en&

&erclo n>ec&on (L'*). & =a een 33e&ed &=a& ' cell re$one -a? e correla&ed&= ac&eral rden and, &=ere>ore, -a? =aered -on&= o>

ona%d ("H) $reerence

a no& 3n>can& (P J 0.10). '=e &=rd +'A aa? con&ned &o e $o& 10

$ar&c$an&, &= $er&en&l? ele

quanti feron

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