quinidine toxicity
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Quinidine is indicated for atrial fibrillation and flutter,and life-threatening ventricular arrhythmia.
Optimalserum concentrationsare in the range of 2.0
to 5.0 mcg/mL, with toxicity apparent at levels > or=6.0 mcg/mL.
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The half life of quinidine is 6 to 8 hours, and the druglacks any significant active metabolites.
Physiologic processes that generally reduce hepatic
metabolism and renal clearance increase serumquinidine levels
while co-medication with cytochrome p450 (CYP)enzyme inducers enhances clearance and results in
lower blood concentrations.
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Treating and preventing certain abnormal heartrhythms.
Quinidine sulfate is an antiarrhythmic.
It works by stabilizing the heart rhythm in conditionsin which the heart is beating too fast or in an irregularrhythm (Antiarrhythmic effect).
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Myasthenia Gravis Complete Heart Block
Partial Heart Block
Prolonged Q-T Interval on EKG
Chronic Heart Failure
Abnormally Low Blood Pressure
Emphysema, Liver Problems
Kidney Disease, Psoriasis Poisoning by the Drug Quinidine
Poisoning by the Heart Medication Digitalis
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Heart Rhythm Problems from Digitalis or Digoxin Condition of Increased Mast Cells
Problems with Food Passing Through the Esophagus
Anemia from Pyruvate Kinase and G6PD Deficiencies
Low Amount of Magnesium in the Blood
Low Amount of Potassium in the Blood
Delay in Activation of the Left Ventricle of the Heart
Defect in Heart's Electrical Intra-ventricularConduction
Decreased Blood Platelets
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QUINIDINE TOXICITYThe toxic reaction of the
body to the substance,possibly via allergic
reaction or overdose.
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ECGchanges
Heartblock
Asystole
Ventriculartachycardia Ventricularfibrillation
Syncope
Seizures
Coma
Death
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Symptoms of toxicity (cinchonism) include :
Tinnitus
light-headedness
prematureventricularcontractionsAtrio-ventricularblock.
Gastrointestinaldistressis a frequent side effect,which becomes more severe and is associated with
nausea and vomiting at higher drug concentrations.
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Verapamiland Quinidine interaction
Alti-Verapamiland Quinidine interaction
Calan and Quinidine interaction
Calan SRand Quinidine interaction Chronovera and Quinidine interaction