rectal cancer: poster session reviewmedia.aiom.it/userfiles/files/doc/aiom-servizi/... · sara...
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Rectal cancer:
Poster Session Review
AIOM PostASCO GI
Roma, 5-6 febbraio 2016
Sara Lonardi SS Trattamento Multidisciplinare Tumori Colorettali - UOC Oncologia Medica 1
Dipartimento di Oncologia Clinica e Sperimentale
Istituto Oncologico Veneto – IRCCS, Padova
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Rectal Cancer Poster Session
Estimation of risk
Combined-modality treatment
Prognostic factors
Fields of improvement
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Estimation of risk (#716)
Combined-modality treatment
Prognostic factors
Fields of improvement
Rectal Cancer Poster Session
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Nomogram for prediction of response to neoadjuvant CRT
Methods: Data from 309 patients enrolled in FOWARC study.
Pre-treatment clinical parameters collected to build a nomogram for pCR
Zhang J et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 716)
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Univariate/multivariate analysis of pretreatment parameters
Zhang J et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 716)
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Nomogram for prediction of response to neoadjuvant CRT
Zhang J et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 716)
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Estimation of risk (#716)
Combined-modality treatment
(#691, #657, #677, #737, #713)
Prognostic factors
Fields of improvement
Rectal Cancer Poster Session
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Same overall survival
Better local control
Reduced toxicity
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Sineshaw HM et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 691)
Stage II/III rectal adenocarcinoma within the National Cancer Data Base
undergoing surgery between 2004-2012 were analyzed (n=66197).
Treatment patterns in the US over the past decade
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OS in st II-III rectal cancer by treatment
Sineshaw HM et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 691)
5-yr OS:
NACRT:
72.4%
surgery and adj CRT: 70.9%
surgery alone: 44.9%
definitive CRT: 48.8%
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Effect of combined neoadjuvant chemoradiation on OS
Stage II/III rectal adenocarcinoma within the National Cancer Data Base
undergoing surgery between 2006-2012 were analyzed (n=32978).
Sun Z et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 657)
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Stage II/III rectal adenocarcinoma within the National Cancer Data Base
undergoing surgery between 2006-2012 were analyzed.
Sun Z et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 657)
62%, 69%, 71%, 74%,
5y-OS
Effect of combined neoadjuvant chemoradiation on OS
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Treatment impact on outcomes vs surgery alone
Sun Z et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 657)
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Sun Z et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 657)
CRT impact on outcomes vs chemo/Rt alone
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Optimal timing for curative surgery after CRT
Retrospective study on LARC (cT3-4N0-2M0) receiving preoperative CRT followed by
TME from 2003 to 2014, at 8 institutions in Korea (n=1786).
Kwak YK et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 677)
Primary EP:
to evaluate the period of
highest downstaging and
ypCR rates to determine the
optimal timing for surgery
after CRT.
Downstaging rates peaked between 6 and 7 weeks and declined afterwards.
ypCR rates increased from 5 to 6 weeks and decreased after 9 to 10 weeks.
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Optimal timing for curative surgery after CRT
Complete tumor regression: 9.1% vs.13.2%, p = 0.004
Sphincter preservation rates: 89.9% vs. 92.4%, p = 0.078
No statistically significant difference regarding OS and DFS
Kwak YK et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 677)
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Pachón Olmos V et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 737)
Retrospective study on LARC (cT3-4N0-2M0) receiving preoperative CRT followed by
TME from 2003 to 2011, single Institution (n=171).
Surveillance and timing of surgical resection after CRT
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Pachón Olmos V et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 737)
Timing of surgical resection after CRT and outcome
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Lorimer PD et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 713)
NCDB Retrospective study on non-metastatic rectal cancer (2004-2011) who
underwent neoadjuvant therapy followed by surgical resection (n=7,859)
The incidence of pCR was associated with favorable tumor factors (size, grade, T
classification), demographics (insurance status) as well as treatment factors (time
between radiation and surgery and institutional volume).
pCR rates after neoadj tx: an analysis of the NCDB
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Estimation of risk (#716)
Combined-modality treatment
(#691, #657, #677, #737, #713)
Prognostic factors (#575, #661, #693)
Fields of improvement
Rectal Cancer Poster Session
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Sprenger et al,J Clin Oncol 34, 2016 (suppl 4S; abstr 575)
Host immune response prognostic role after CRT
mRNA and protein expression of the B- and T-cell chemokines CXCL13 and
CXCL9 in LARC undergoing preoperative CRT and surgery (n=77)
Intratumoral mRNA expression levels of the T-cell activator CXCL9 (p < 0.001) as
well as the B-cell chemokine CXCL13 (p < 0.01) were inversely correlated with the
development of distant metastasis.
Patients with high CXCL9 (p < 0.0001) or CXCL13 expression (p < 0.01) had a
significantly prolonged DFS.
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Integration of strategies in rectal cancer
Kim H et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 661)
Pts treated with nCRT followed by curative radical surgery (n=141)
LPLN before nCRT: 16 pts.
Group 1: 7 pts showing disappearance of LPLN after nCRT
Group 2 9 pts showing persistance of LPLN after nCRT
Group 1: similar oncologic outcome with ypTNM stage II (P = 0.761 ).
Group 2: tendency of worse oncologic outcome than ypTNM stage III (P = 0.135)
P = 0.058
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Outcome prediction by cTNM stage vs ypTNM stage
Pts treated with nCRT followed by curative radical surgery (n=141)
cTNM stage did not demonstrate any correlation with DFS
(cII % vs cIII %, P = 0.266).
Kim H et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 693)
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Outcome prediction by cTNM stage vs ypTNM stage
3-year DFS by ypTNM:
- ypI, 87.9%;
- ypII, 67.8%;
- ypIII, 53.3%
Kim H et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 693)
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Estimation of risk (#716)
Combined-modality treatment
(#691, #657, #677, #737, #713)
Prognostic factors (#575, #661, #693)
Fields of improvement (#502, #673)
Rectal Cancer Poster Session
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Fields of improvement
Acute and late
toxicities Improved
survival
Clinical
benefit
Reduce distant
metastases
Optimize
local control
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Risk/benefit balance improvement
Acute and late
toxicities
Clinical
benefit
Neoadjuvant /
Consolidation /
adjuvant CT
intensification of
concurrent CRT
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Phase II trial of perioperative chemotherapy using
FOLFOX with panitumumab for LARC
Multicenter phase II trial on clinical stage III, kRAS wt rectal cancer
Primary outcome: response rate of the primary lesion measured by T2
weighted sagittal image of magnetic resonance imaging.
Ota M et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 502)
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Ota M et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 502)
Between January 2012 and December 2014, 42 out of 43 patients completed
preoperative chemotherapy
There was no progressive disease in the 42 patients
All of the 43 participants underwent resection without mortality or severe
complications.
Phase II trial of perioperative chemotherapy using
FOLFOX with panitumumab for LARC
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Induction treatment with FOLFOXIRI + bev CRT + bev:
The phase II TRUST trial
LARC at < 12 cm from the anal verge
N+ or cT4 or high risk cT3 (MRI criteria)
Primary endpoint is 2-year disease-free survival (DFS).
Vivaldi C et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 673)
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Patients characteristics
Vivaldi C et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 673)
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Induction treatment toxicities
Vivaldi C et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 673)
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Induction treatment toxicities
Vivaldi C et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 673)
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Concomitant chemoradiation
Vivaldi C et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 673)
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Activity
Vivaldi C et al, J Clin Oncol 34, 2016 (suppl 4S; abstr 673)