2004

KetonesQ 0350 Reduction of 1,2-Dicarbonyl Compounds Mediated by the Combination of Phos-

phine and Lewis Acid. — Several 1,2-diketones are efficiently reduced by a combi-nation of PPh3/AlBr3 in the presence of 1 equivalent of water to afford α-hydroxy car-bonyl compounds in good yields. Keto thioester (VI) is selectively reduced at the thioester function. — (KIKUCHI, S.; HASHIMOTO*, Y.; Synlett 2004, 7, 1267-1269; Dep. Chem. Biotechnol., Grad. Sch. Eng., Univ. Tokyo, Hongo, Tokyo 113, Japan; Eng.) — Klein

42- 094