Review of the PTR-ToF technique

Detection limit: < 1 pptvSensitivity: > 1000 (up to 2500) cps/ppbv (Benzene)Mass Resolution: > 6000 (up to 10,000)

Mass resolution > 6000 (up to 10,000) m/Δm (FWHM)

Response time 100 ms

Sensitivity > 1000 (up to 2500) cps/ppbv for m/z 79 @ Resolution > 6000> 2000 (up to 4500) cps/ppbv for m/z 181 @ Resolution > 6000

Detection limits (LoD) < 10 pptv (averaged over 60 sec) m/z 79< 1 pptv (averaged over 60 sec) for m/z 181

Linearity range 1 pptv - 0,5 ppmv

Pulse frequency up to 200 kHz

Adjustable flow 50 -1000 sccm

Inlet system heating range up to 180°C (2nd inlet system and other inlet options on request)

Reaction chamber heating range 40 - 120°C

Dimensions (w x h x d) 60x110x80 cm

Weight < 175 kg

Power requirements 100-115/200-230 V, max 1500 W

Technical Specifications:

Uses of the device for breath

• Real-Time Breath Analysis with PTR-MS• Breath-Markers for Smoking• Biomarkers for Lung-Cancer• Pharmacokinetics• Monitoring metabolic processes

ProjectsName BAMOD

Acronym Breath-gas analysis for molecular-oriented detection of minimal diseases

Type of funding EU Project, 6th Framework Program (FP6)

Duration 2004 - 2009

Project Website http://eu-proposal.voc-research.at/

Kohl, I., et al., "First observation of a potential non-invasive breath gas biomarker for kidney function.", J Breath Res, vol. 7, no. 1: Ionimed Analytik GmbH, Eduard Bodem Gasse 3, A-6020 Innsbruck, Austria., pp. 017110, Mar, 2013. LINK

Herbig, J.., et al., "Breath Analysis with PTR-MS: More breath markers for lung cancer", 5th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 31-33, 2011. LINK

Another project• development of nano-sensors for medical breath analysis. PTR-MS

technology complements the sensor information and develops a novel calibration device for sensor characterization. The acronym LCAOS is derived from Lung Cancer detection with an Artificial Olfactory System. In this project novel types of sensors, based on chemically-sensitive field effect transistors (FETs), will be developed and employed for breath analysis. The goal is a cheap and hand-held device for the detection of volatile biomarkers for lung cancer in breath.

• PTR-MS is used in the project to identify breath markers, with the aim to develop smaller, sensor based systems for these markers. We contribute our expertise in breath analysis and PTR-MS technology.

Different methods

Problematic concentration data due to binary bonding site

Gas detection on chip

Might be good for one use - disposable

More info

• http://www.ionicon.com/applicationshowcases/medical-applications