samarkandi 2005

BA CKGROUND AND OB JECTI VE: METHODS: RESULTS: DISCUSSION: PubMed Commons home Eur J Anaesth esiol. 2005 Mar;22( 3):189-96. Melatonin vs. midazolam premedicatio n in chil dren: a double-blin d, placebo-controlled study. Samarka ndi A , Nagu ib M, Riad W, Thal aj A, Alotibi W, Aldammas F, Albassam A. Abstr ac t Unlike midazolam, melatonin premedication is not associated with cognitive imp airment in adul ts despite its anxiolytic properties. The use of mel atonin as a premed icant in children has not been reported. This randomized, double-blind, placebo-controlled study compared the perioperative effects of different doses of melatonin and midazolam in children. Seven group s o f children (n = 15 in eac h) w ere randomly assigned to receive one of the following premedicants. Midazolam 0.1, 0.25 or 0.5 mg kg(-1) orally, melatonin 0.1, 0.25 or 0.5 mg kg(-1) orally each mixed in 15 mg kg(-1) acetaminophen, or placebo only (15 mg kg(-1) acetaminophen). Anxiety and temperament w ere evalu ated befor e and after administration of the study d rug, on separation f rom parents and on the introduction of the anaesthesia mask. At week 2 postoperatively , the behaviour of the child ren was measured by the Post Hospitalization Behavi our Questio nnaire. Melatonin or midazolam each in doses of 0.25 or 0.5 mg kg (- 1) were equall y eff ective as premedicants in allev iating separation anxiety and anxiety as soc iated with the introduction of the anaesthesia mask. A tr end w as noted fo r midazolam to prolong rec overy times as the dosage increas ed. The use of mel atonin w as as socia ted w ith a low er incidence ( P = 0.049) of excitement at 10 min postoperatively , and a lower incidence (P = 0.046) of sleep disturbance at week 2 postoperatively than that observed with midazolam and control groups. No postoperative excitement was noted in the melatonin groups at 20, 30 and 45 min. Melatonin w as not only as ef fec tive as mid azolam in al leviatin g preoperative anxiety in child ren, but it was also as soc iated wi th a tendency towards fas ter r ecover y , low er incidence of excitement postoperatively and a lower incidence of sleep disturban ce at week 2 postoperatively . PMID: 1585 2991 [Pu bMed - ind ex ed for MEDLIN E] PubMed Common s Ab stract 1 Aut ho r i nf or mati on Publication T ypes, MeSH T erms, Subs tances Link Out - more resources Melaton in vs. midazolam premedicat ion in children: a dou ble-blind, pl... ht tp://www.ncbi.nlm.nih.gov/p ubm ed/15852991 1 of 2 10/11/2015 2:35 PM

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7/23/2019 samarkandi 2005

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BACKGROUND AND OBJECTIVE:

METHODS:

RESULTS:

DISCUSSION:

PubMed Commons home

Eur J Anaesthesiol. 2005 Mar;22(3):189-96.

Melatonin vs. midazolam premedication in children: a double-blind,placebo-controlled study.

Samarkandi A , Naguib M, Riad W, Thalaj A, Alotibi W, Aldammas F, Albassam A.

Abstract

Unlike midazolam, melatonin premedication is not associated with

cognitive impairment in adults despite its anxiolytic properties. The use of melatonin as a premedicant in

children has not been reported. This randomized, double-blind, placebo-controlled study compared the

perioperative effects of different doses of melatonin and midazolam in children.

Seven groups of children (n = 15 in each) were randomly assigned to receive one of the

following premedicants. Midazolam 0.1, 0.25 or 0.5 mg kg(-1) orally, melatonin 0.1, 0.25 or 0.5 mg kg(-1)

orally each mixed in 15 mg kg(-1) acetaminophen, or placebo only (15 mg kg(-1) acetaminophen). Anxiety

and temperament were evaluated before and after administration of the study drug, on separation from

parents and on the introduction of the anaesthesia mask. At week 2 postoperatively, the behaviour of the

children was measured by the Post Hospitalization Behaviour Questionnaire.

Melatonin or midazolam each in doses of 0.25 or 0.5 mg kg(-1) were equally effective as

premedicants in alleviating separation anxiety and anxiety associated with the introduction of theanaesthesia mask. A trend was noted for midazolam to prolong recovery times as the dosage increased.

The use of melatonin was associated with a lower incidence (P = 0.049) of excitement at 10 min

postoperatively, and a lower incidence (P = 0.046) of sleep disturbance at week 2 postoperatively than

that observed with midazolam and control groups. No postoperative excitement was noted in the

melatonin groups at 20, 30 and 45 min.

Melatonin was not only as effective as midazolam in alleviating preoperative anxiety in

children, but it was also associated with a tendency towards faster recovery, lower incidence of

excitement postoperatively and a lower incidence of sleep disturbance at week 2 postoperatively.

PMID: 15852991 [PubMed - indexed for MEDLINE]

PubMed Commons

Abstract

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