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    THE BODY

    Constantly reacting and

    adjusting

    HOMEOSTASIS

    ENVIRONTMENTAL

    CHANGES

    InternalExternal

    STIMULI

    BRAIN

    SPINAL

    CORD

    NERVES

    Sensed & conveyed

    the messages

    (inputs)

    INTEGRATION

    analyzed

    combined

    compared

    coordinated

    MUSCLES

    (skeletal/smooth/cardiac)

    GLANDS (endocrine/exocrine)NERVES

    HOMEO-STASIS

    (afferent)

    (efferent)

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    HOMEOSTASIS (Lat. homois : same; stasis : standing still)

    A state of inner balance and stability in the body, which remains

    relatively constant despite external environmental changes

    CNS

    (brain &

    spin. cord)

    PNS

    (periph. NS)

    SOMATIC

    NS

    AFF.

    (SENSORY)

    DIVISON

    VISCERAL

    NS

    EFF.

    (MOTOR) DIV.

    (AUTONOMIC NS)

    SYMPATHETIC

    NS

    PARASYMP.

    NS

    (Comple-

    ment each

    other)

    (aff. div.)

    (eff. div.)

    aff. eff.

    aff. div.*

    eff. div.**

    Responds to stress andemergency situations)

    Conserves & restorebody resources

    stimulates voluntarymuscles

    processes

    sensory input

    * Processessensory input from

    visceral organ

    ** triggers

    response in

    involunt. musc.& glands

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    Complicated structures and interrelationships

    Convergence and divergence

    (the flow of info.)

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    NEURONS (NERVE CELLS):

    STRUCTURAL AND FUNCTIONAL UNITS

    OF THE NERVOUS SYSTEM

    NEURONS (NERVE CELLS):

    ARE SPECIALIZED TO TRANSMIT IMPULSES:

    - FROM SHORT TO RELATIVELY LONG DISTANCES

    - FROM ONE PART OF THE BODY OR CENTRAL NERVOUS

    SYSTEM TO ANOTHER

    HAVE TWO IMPORTANT PROPERTIES:

    1. EXCITABILITY (the ability to respond to stimuli)

    2. CONDUCTIVITY (the ability to conduct a signal)

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    CLASSIFICATION OF FUNCTIONAL

    COMPONENTS OF NERVES

    The functional components of the neurons and their fibers

    of peripheral nervous system may be clasified as follows:

    1. GENERAL SOMATIC AFFERENT (GSA) FIBERS:

    carry sensory information from somatic tissues

    (skin, voluntary/skeletal muscles, joints, connective tissues)

    to the CNS

    2. GENERAL VISCERAL AFFERENT (GVA) FIBERS:

    carry information from the visceral organs to the CNS

    CNS GENERAL /SOMATIC

    RECEPTORS

    CNS VISCERORECEPTORS

    (aff.)

    (aff.)

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    3. GENERAL SOMATIC EFFERENT (GSE) FIBERS:

    carry nerve impulses from CNS to the most of the

    voluntary/skeletal muscles of the body

    (- the muscles contract

    - the muscles derived from masses of cells called

    myotomes)

    4. GENERAL VISCERAL EFFERENT (GVE) FIBERS:

    carry impulses from the CNS that modify the activities

    of the heart, smooth muscles (included vasa), and glands

    (the fibers of autonomic nervous system)

    CNS EFFECTORS:

    SKELETAL MUSCLES

    (eff.)

    CNSEFFECTORS:

    SMOOTH/VASA & CARDIAC

    MUSLES.,GLANDS

    (eff.)

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    5. SPECIAL VISCERAL EFFERENT (SVA) FIBERS:

    carry impulses from the brain to the voluntary

    muscles derived from embryonic branchiogenic

    (gill) arches

    (this visceral musculature is found in the jaw,

    muscles of facial expression, pharynx, and larynx

    6. SPECIAL SOMATIC AFFERENT (SSA) FIBERS:

    carry neural information from the receptors of the

    olfactory (smell), optic (sight), auditory (hearing),

    vestibular (balance), and gustatory (taste)

    systems to the CNS

    CNS EFFECTORS:

    BRANCHIAL/VISCERAL MUSC.

    (eff.)

    CNSRECEPTORS:

    SPECIAL SENSORYORGANS

    (aff.)

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    SENSORY/AFFRENT SYSTEM

    (CNS RECEPTOR)

    * COLLECTING

    * PROCESSING

    EXTERNAL

    (somatosensory)

    RECEPTORS

    INTERNAL

    (viscerosensory)

    RECEPTORS

    (Info)

    Tension, blood pressure,

    pressure, chemical

    composition of the blood

    (hormones, glucose, CO2,

    ions/electrolytes)

    (events/stimuli)

    CONTACT

    (pain, temp., touch, pressure)

    DISTANT

    (sound, light, odours)

    (INFO.)

    (CNS) RECEPTOR

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    MOTOR/EFFERENT SYSTEM

    ( CNS EFFECTOR)

    VISCEROMOTORIC VISCERA, VASA

    Smooth muscles

    Myocardium

    ExocrineEnzymes

    Glandular cells

    EndocrineHormones

    MOTOR/

    AFFERENT

    SYSTEM

    SOMATOMOTORIC SKELETAL MUSCLES

    (INFO.)

    EFFECTORS

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    Three functional classes of neurons: 1. Afferent neuron,

    2. Interneuron (in the CNS), and 3. Efferent neuron

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    DIVISIONS OF THE NERVOUS SYSTEM

    NERVOUS SYST.

    (neurons: 1011

    neuroglia: 1012)

    CNS

    PNS

    BRAIN

    (encephalon)

    SPINAL CORD

    (medulla spinalis)

    CRANIAL NERVES:12 pairs

    (from the brain)

    SPINAL NERVES: 31 pairs

    (from the spinal cord)

    VISCERAL

    unconscious)

    SOMATIC

    (conscious)

    AFFERENT

    EFFERENT

    (AUTONOMIC)

    SYMPATHETIC

    PARASYMPATHETIC

    Somatic tissues

    (skeletal muscles,skin, bones)

    smooth & cardiac

    muscles, glands

    Smooth & cardiac muscles, glands

    (structural)

    (functional)

    Within the

    cranial cavity

    Within the

    vertebral canal

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    SPINAL NERVES (31)

    Cervical (8: C1-C8)

    Thoracal (12: T1-T12)

    Lumbar (5: L1-L5)

    Sacral (5: S1-S5)

    Coccygeal (1: co.)

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    Principal parts of the

    brain (medial aspect)

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    PERIPHERAL NS:

    CRANIAL NERVES(N IN XII)

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    AUTONOMIC NS*

    SYMPATHETIC NS

    Center:

    thoracolumbar

    PARASYMPATHETIC NS

    Center: cranisacral

    *ANS: unconscious

    component of the NS

    (regulates the internal

    organs/viscera)

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    NEURON

    (NERVE CELL) STRUCTURAL AND FUNCTIONAL UNIT OF NS*

    SOMA (cell body)

    (collective: gray matter/sustantia grisea)

    COMPONENT

    DENDRITES

    PROCESSES

    AXON (collective: white matter/

    substantia alba)

    TERMINALSYNAPSE

    (contact with

    other neuron/

    effector cells)

    Fig. 1-2

    *NEURON:

    Specialized to receive info.

    Transmits electrical

    impulses (action potentials)

    Influences other effector

    tissues (neuron, muscle (skeletal,smooth, cardiac, glands)

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    Axon

    Collateral

    Axon

    terminal

    Cell body/soma

    NEURON (EM SCANNING)

    Nucleus

    Axon hillock

    Dendrite

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    CELLULAR

    COMPONENTS

    OF A NEURON

    SYNAPSES (interne ronal contacts)

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    SYNAPSES (interneuronal contacts)

    1. Axosomatic 2. Axodendritic 3. Axoaxonic 4. Dendrodendritic

    Axon terminal

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    CONVERGENCE & DIVERGENCE

    PRESYNAPTI

    INHIBITION

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    Types of neuron:

    1. Unipolar

    2. Bipolar

    3.Pseudounipolar

    4. Multipolar

    HOW NEURONS COMMUNICATE

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    HOW NEURONS COMMUNICATE

    TO EACH OTHER ?

    SYNAPSE

    CONSISTS OF:

    -Presynaptic

    element (part of

    axon terminal)

    -Synaptic

    cleft/space

    -Postsynaptic

    region (receptor at

    the postsynaptic

    membrane of the

    innervated neuronor effector

    structure)

    Electrochemical communication:action pot. propagation (electrical) + chemical (NT) transmission

    Neurotransmitter (NT)

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    SPINAL CORD

    INSIDE THE VERTEBRAL COLUMN

    (in the vertebral canal)

    31 SEGMENTS

    31 PAIRS OF SPINAL NERVES CERVICAL (C) : 8

    THORACAL (T) : 12

    LUMBAR (L) : 5

    SACRAL (S) : 5

    COCCYGEAL (Co) : 1 CONTAINS: - SENSORY FIBERS

    - MOTOR NEURONS

    - ASCENDING/DESCENDING FIBERS

    (PATHWAYS/TRACTS TO AND FROM THE BRAIN)

    REFLEX CENTER

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    CROSS-SECTION OF THE SPINAL CORD

    Gray matter (substantia grisea)

    White matter (substantia alba)

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    BRAIN

    The largest organ of the bodyComposed of soft tissue (jelly) Needs strict protection

    In adult: 1,300 g

    Mushroom-shaped

    Medial aspect of

    the brain

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    BRAIN

    BRAIN STEM DIENCEPHALON CEREBRUM CEREBELLUM

    MEDULLA

    OBLONGATAPONS

    MESENCEPHALON

    THALAMUS

    HYPOTHALAMUS

    CEREBRAL

    CORTEX

    BASAL

    GANGLIA

    A

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    Surface anatomy of the brain (A. lateral & B. medial)

    AB

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    PROTECTION & COVERINGS

    OF CNS (protection against injury)

    PROTECTION

    1. BONES: - CRANIAL BONES (CRANIUM) (for the brain)

    - VERTEBRAL COLUMN (for the spinal cord)

    2. MENINGES: - CRANIAL MENINGES (surround the brain)

    - SPINAL MENINGES (surround the spinal cord)

    3. CEREBROSPINAL FLUID (CSF)

    - Circulates through the subarachnoid space

    - Formed by filtration and secretion from CHOROID PLEXUSES

    (network of capillaries); located in the ventricles of the brain

    BLOOD-BRAIN BARRIER (BBB): - permits certain substances to

    enter the CSF but prohibits the others Protects the brain and

    spinal cord from harmful substances

    - formed by various components : astrocyte end feet, capillary

    basal membr. & capillary endothelial cells (nonfenestrata)

    MENINGES &

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    MENINGES &

    CEREBROSPINAL

    FLUID (CSF)/LIQUORCEREBROSPINALIS (LCS)

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    CEREBAL VENTRICLES

    1. Lateral ventricles (right/left, in

    the cerebral hemispheres)

    2. Third ventricle (between

    right& left diencephalon)

    3. Aqueductus cerebri (Sylvius)

    4. Fourth ventricle (ventral to

    cerebellum, dorsal to ponsand med. Obl.)

    CSF CIRCULATION

    Choroid plex. (in the V Lat. + V III)

    V III Cerebral aqueductV IV ( For. Magendie , For.

    Lushka) Subarachnoid space

    (around the brain + spinal cord)

    Arachnoid granulations

    vv. emmissariae V.

    jugularis int. Cor

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    BASAL NUCLEI/GANGLIA

    1.LENTICULAR

    NUCLEUS

    2.CAUDATE

    NUCLEUS

    3.AMYGDALA

    (function:

    limbic

    system)

    a. PUTAMEN

    b. GLOBUSPALLIDUS

    1

    2

    3

    Thalamus

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