SCLEROSING AGENTS SCLEROSING AGENTS

Dr Taj Khan Dept. of Pharmaceutical Chemistry, Oriental College of Pharmacy, Sanpada, New Mumbai.

IntroductionIntroductionSCLEROSING AGENTSSCLEROSING AGENTSsodium morrhuatesodium morrhuateSodium tetradecyl sulfate (STS)Sodium tetradecyl sulfate (STS)

Sclerosis:Sclerosis: - Abnormal hardening of body tissue.- Abnormal hardening of body tissue. -In medicine, -In medicine, sclerosissclerosis (also spelled (also spelled

sclerosussclerosus ( (GreekGreek "hard") is the stiffening "hard") is the stiffening of a structure, usually caused by a of a structure, usually caused by a replacement of the normal organ-specific replacement of the normal organ-specific tissue with tissue with connective tissueconnective tissue..

Introduction Introduction SCLEROSING AGENTS:SCLEROSING AGENTS:Definition:Definition: are substances that cause a marked tissue are substances that cause a marked tissue

irritation or thrombosis with subsequent irritation or thrombosis with subsequent local inflammation and tissue necrosis local inflammation and tissue necrosis resulting in fibrosis and tissue contraction. resulting in fibrosis and tissue contraction. e.g. e.g.

sodium morrhuate,sodium morrhuate, Sodiumtetradecylsulfate(STS).Sodiumtetradecylsulfate(STS).

Sclerosing agents:Sclerosing agents: are some injections which are given to are some injections which are given to

irritate and damage the wall of a vein irritate and damage the wall of a vein resulting in its occlusion eg. Closing. This resulting in its occlusion eg. Closing. This is done in the case of varicose veins, is done in the case of varicose veins, haemorrhoids. haemorrhoids.

Varicose veinsVaricose veins : veins that have become : veins that have become enlarged and twisted. The term commonly enlarged and twisted. The term commonly refers to the veins on the leg, although refers to the veins on the leg, although varicose veins can occur elsewhere.varicose veins can occur elsewhere.

varicose veinsvaricose veins

varicose veinsvaricose veins

SCLEROSING AGENTSSCLEROSING AGENTS

sodium morrhuate Injection:sodium morrhuate Injection: -It is a sterile solution of the sodium salts of -It is a sterile solution of the sodium salts of

the fatty acids of Cod Liver Oil having the fatty acids of Cod Liver Oil having 50mg of sodium morhuate per ml. 50mg of sodium morhuate per ml.

An antimicrobial agent (NMT 0.5%) and An antimicrobial agent (NMT 0.5%) and ethyl/ benzyl alcohol (NMT 3%) is usually ethyl/ benzyl alcohol (NMT 3%) is usually added. added.

is prepared by the saponification of is prepared by the saponification of selected Cod Liver Oils.selected Cod Liver Oils. Morrhuate Sodium occurs as a pale-Morrhuate Sodium occurs as a pale-yellowish, granular powder with a slight yellowish, granular powder with a slight fishy odour and is soluble in water and in fishy odour and is soluble in water and in alcohol.alcohol.Use: As sclerosing agent, for varicose Use: As sclerosing agent, for varicose veins.veins.

Sodium tetradecylsulfateSodium tetradecylsulfate(STS)(STS)

It is It is 7-ethyl-2-methyl-4-undecanyl sulfate 7-ethyl-2-methyl-4-undecanyl sulfate sodium salt. Sotradecolsodium salt. Sotradecol

- is a sclerosant drug, used in the treatment is a sclerosant drug, used in the treatment of varicose and spider veins of the leg, of varicose and spider veins of the leg, during the procedure of sclerotherapy.during the procedure of sclerotherapy.

Being a detergent‐based chemical, its Being a detergent‐based chemical, its action is on the lipid molecules in the cells action is on the lipid molecules in the cells of the vein wall, causing destruction of the of the vein wall, causing destruction of the internal lining of the vein and eventual internal lining of the vein and eventual sclerosis of the vein.sclerosis of the vein.It is used in concentrations ranging from It is used in concentrations ranging from 0.1%to3% for this purpose.0.1%to3% for this purpose.