8/9/2019 sk grlen immun yetmezlikler

1/5

8/9/2019 sk grlen immun yetmezlikler

2/5

dhfj fhporwbw dhwpwrafkpf`r* Bw bgbgkhgr`g mfsfpj chk mflpfhfrj`fj cpcbfrgj

pgkrfrhfsfj |gsf fr gjlgkycsdj -WRPC( dpcp( ycj~cp( brdjcp( bf~gj ujadjc#( jf`crgj

yguycy( agjgjncp( yghhcp dhfbchagkpg`cr* Pgkrfrhfsfj cymfh( fr |frcighhf( w~fa drfh

kfj`c`f bch`crchacpcr* Fpduck mfypfhkhfr -mgg~s cjlfjp( go~gaf( o`f cjpdhgrfjy# jf`cr

`gch`cr*Gjlgkycsdjw dhfj mfypfhfr`f gjlgkycsdjhfr grkgj`gj pg`f|c g`chaghc`cr* Mfypfhfrj

bf~hfrj`f urdlchfkpck fjpcbcdpck kwhhfjhafy ogrgkgbchcr* Ic``c gjlgkycsdjhfr dhfj |gsf

fjpckdr ig|fb dk ~fsl dhfjhfr`f c|co

9 fs ydjrf ygrwa Co |g fjpckdr ig|fuhfr pgkrfr `ggrhgj`crchaghc`cr*

Mfypfhfrj dw 2 sf ic|frj`f `~ghagkpg fjifk bf~ mfypfhfr`f 7 sfjf mfppf `fmf

chgrc sfhfrf kf`fr `g|fa g`gbchagkpg`cr* Bcrhckpg CoF `kh bwhwjfj mfypfhfr`f

yghgkpcl CoF gkyckhcc oghcgbchagkpg`cr* Mfypfhfr`f kgycj pfj fjifk CoO `~gscjcj

jdrafhg jagycj`gj ydjrf kdjwhfbchagkpg`cr*

CoO ywborwu gkyckhccCoO ywborwuhfrj`fj bcr |gsf bcrkfjj 2Y@ fhpj`f( pdpfh CoO `~gscjcj jdrafh |gsf

jdrafhg sfkj ~gs`g dhafy chg kfrfkpgrc~g`cr*

Jdrafh uduwhfysdjwj sfkhfk '25 ycj`g CoO ywborwu gkyckhcc bgkhgj`cc

bghcrpchagkpg`cr* Bw bcrgshgrcj dwjhww fygaupdafpck dh`wwj`fj bw `wrwa mfypfhk

`gch khcjck hfbdrfpw|fr bwhowywjw pfrcl gpagkpg`cr* Khcjck dhfrfk jgahc dhfj CoO

ywborwu gkyckhcc( pgkrfrhfsfj gjlgkycsdj |g fjpckdr sgpag~hcc chg bcrhckpg`cr* Mfypfhfrj

dwj`f pgkrfrhfsfj rgyucrfpw|fr gjlgkycsdj ag|iwppwr* CoO ywborwu gkyckhcc `cgr CS

hgrg `g -CoF gkyckhcc( fpfkyc!pghfjncgkpf~c ocbc#ghck g`gbchcr*

CoO ywborwu gkyckhcc bwhfjfj mfypfhfr ccj`g CoO0( CoO2( CoO9 |g CoO6cj yrfy chg '05(

'2=( ' 6?( ' 60 drfjj`f dh`ww bch`crchacpcr* Bcr`gj lf~hf ywbowbwj bcr`gj `k

dhafy |gsf CoF gkyckhcc chg bcrhckpghcc yk orhagkpg cr*

CoO0 gkyckhccj`gj ydjrf diwkhfr`f gj yk orhgj CoO2 ywborwu gkyckhcc( grckcjhgr`g

cyg CoO9 ywborwu gkyckhcc`cr* Yghgkpcl CoO6 gkyckhcc ygsrgkpcr* CoO0 gkyckhccjcj mga

grckcj mga diwkhfr`f '65!25 sg kf`fr bwhwjfbch`cc bch`crchagkpg`cr( ogjghhckhg

khcjck jgac sdkpwr* Fjifk bcrhckpg pgkrfrhfsfj ujadjc |g brdjcgkpf~c bwhwjfj

|fkfhfr bch`crchacpcr( bw mfypfhj jg`gjc dhafkpfj dk afrkgr dhfrfk kfbwh g`chacpcr*

CoO2 gkyckhcc pgkrfrhfsfj gjlgkycsdjhfrhf gj yk bcrhckpg bwhwjfj ywborwu gkyckhcc`cr |g

CoF |g$|gsf CoO0 gkyckhcc ghck g`gbchcr* Bw mfypfhfrj dwjhwwj`f yugyclck fjpckdr

sfua bd~wkhww ag|iwppwr* diwkhfr f orhgj CoO2 gkyckhcc < sfj fhpj`fkc diwkpf

YIOM `gj cschgagjcj bcr ufrfy dhfrfk drpfsf kfbchcr( `dhfsyshf bw sfhfrj fhpj`f

pfj kdsafk ~dr`wr* Mga grckcj mga diwkhfr`f bfkpgrcsgh ufpdngjhgrhg pgkrfrhfsfj

ydhwjwa ycypgac gjlgkycsdjhfr -dpcp( ycj~cp( brdjcp# j uhfj`f`r* Ic``c ycypgack

gjlgkycsdjhfr `fmf f~`r( mfypfhfrj bcrdw fpduckpcr( fypafpck brdjcp ghck g`gbchcr*CoO2 gkyckhcc ~ghhckhg kk diwkhfr`f ~fafjhf ~ghgbchcr*

8/9/2019 sk grlen immun yetmezlikler

3/5

Yghgkpcl CoO6 gkyckhcc `fmf fr gjlgkycsdjhfrhf bcrhckpg`cr |g grckcjhgr`g `fmf lf~hf`r*

CoO6 gkyckhcc pdpfh CoO `~gscjg `g sfjyafkpf |g CoO ywborwu gkyckhcc pfjajf pfa

wsafafkpf`r*

Ygaupdafpck CoO9 gkyckhcc dhfj mfypfhfrj dwjhwwj`f bcrhckpg `cgr ywborwu

gkyckhckhgrc ag|iwppwr*

CoO ywborwu pfscjc bcrdk sgr`g sfuhfbch`cc; bcr |gsf bcr`gj lf~hf ywborwu`khjj yk bwhwjfbchgigc |g fjpckdr sfua gkyckhcc sdkyf khcjck jgacjcjdhaf` bf~ mgkcahgrig csc bchcjag`cc ccj CoO ywborwu gkyckhck pfjy dhafyogrgkgj`gj lf~hf -d|gr!`cfojdyg# kdjwhafkpf`r* CoO ywborwu pfscjc csc ypfj`fr`c~gg`chagac bcr pgyp dh`ww( sf |g uduwhfysdjhfrhf chochc jdrahfr csc bchcjag`cc( |glfrkh gpjck orwuhfr`f ogjgpck |frsfysdjhfr bwhwjfbch`cc ccj `g pfj kdsafk ~drdhafkpf`r*

CoO fhporwuhfr fjpckdr sfua `glgkpc bwhfjfj mfypfhfr`f( yghgkpcl CoF gkyckhccj`g( |gI\C@jcj grkgj jgac dh`ww jhgj mfypfhfr`f ggrhgj`crchaghc`cr*

Mfypf fygaupdafpck cyg |gsf fjpckdr sfua jdrafhyg pg`f|c ogrgkagagkpg |g caaj

sgpag~hckhc dhfrfk kfbwh g`chagagkpg`cr* Pgkrfrhfsfj |g krdjck gjlgkycsdjw dhfj

mfypfhfr`f cyg kdrwswiw fjpcbcsdpck kwhhfjhafh`r* Gjlgkycsdjhfr fjpcbcsdpckhgrhg

kdjprdh fhpjf fhjfasdryf( fr ygaupdahfr |fryf c|co |grchaghc`cr -mfypfhfrj sfkhfk

'65wj`f ogrgkagkpg`cr#*

CoO2 ywborwu gkyckhcc diwkhfr`f gj yk orhgj ywborwu gkyckhcc ckgj ( CoO9 ywborwu

gkyckhccjcj grckcjhgr`g gj yk orhgj gkyckhck dhafy diwkhfrj gj f~j`fj bcr

orwbwj`f ywborwu gkyckhckhgrcjcj `~gh`ccjc `j`ragkpg`cr* ~ghhckhg kdauhgp`gchyg ywborwu gkyckhcc 65 sfj fhpj`fkc diwkhfr`f yudjpfj cschggbchagkpg`cr* Co

ywborwu gkyckhckhgrc bf~ diwkhfr`f |g ~ghhckhg grckcjhgr`g `g|fa g`gbchagkpg |g

I\C@ sg chgrhgsgbchagkpg cr* Mfjoc mfypfhfr`f ogcic mfjoc mfypfhfr`f kfhi dhfif( |gsf

I\C@sg ac `jgigcjc pfmacj gpagk ~dr`wr* Bwj`fj `dhfs Co |g CoO ywborwu

`ggrhgj`crchaghgrcjcj ugrcd`ck dhfrfk sfuhafy ogrgkhc`cr*

Yghgkpcl fjpckdr sfua gkyckhcc>

kc sfj ~grcj`gkc mfypfhfr`f pgkrfrhfsfj bfkpgrcsgh gjlgkycsdjhfr( udhcyfkkfrcp

fjpcngjhgrcj dwjf ig|fbj dhafafy |gsf `k dhafy( ygrwa CoO |g CoOywborwuhfrjj jdrafh |gsf skygk dhafy( urdpgcj fjpcngjhgrg ig|fbj jdrafh dhafy chg

kfrfkpgrc~g`cr* Bw ~ghhckhgr 0= fsj fhpj`f lc~sdhdnck dhfrfk orhgj `wrwaf

bgj~gagkpg`cr*

Yghgkpcl fjpckdr gkyckhcc mgpgrdngj bcr orwu mfypfhkpr* 2!< sf frfyj`f bwhwjfj pcuc

udhcyfkkfrcp fyjf ckc sfj fhpj`f orhgj lc~sdhdnck ig|fuy~hj fbfrph gkhc

dhfbchcr |g ~fafjhf `~ghgbchcr* Mfypfhfr`fj bcr kya cyg YIOMj bcr ufrfy dhfrfk

drpfsf kfbchcr* Udhcyfkkfrcp fjpckdrhfrj dw CoO2 orwbwj`f dh`wwj`fj ywborwu

gkyckhcc |gsf CoF gkyckhcc frfprhafh`r*

8/9/2019 sk grlen immun yetmezlikler

4/5

Yghgkpcl fjpckdr gkyckhcc bwhwjfj mfypfhfrj bcrdw 2!? sf frfyj`f`r |g dw

yudjpfj dhfrfk `~ghagkpg`cr* Bshgig diwkhfr`f pfkcupg fjpckdr ig|fuhfr

pgkrfrhfjafh( ygaupdafpck grckcjhgr I\C@g `ja sjj`gj c~hgjaghc`cr* F~

yfs`f mfypf I\C@jcj grkgj jgacjc pgaych gpagkpg`cr*

Yghgkpcl CoF gkyckhccCoO ywborwu gkyckhcc chg bcrhckpg |gsf pgk bfjf CoF `kh chg kfrfkpgrc~g`cr*Mfypfhfr fygaupdafpck dhfbchgigc ocbc pgkrfrhfsfj bfkpgrcsgh gjlgkycsdj( dpdcaajcpg(kdhhfogj |fykhgr mfypfhk( fpduc( ofyprdcjpgypcjfh ycypga pwpwhwaw( afhcojcpg bwhwjfbchcr*Fjpc CoF fjpckdrhfr dhwfbchagkpg |g CoF cgrgj rjhgrhg fjflhfkpck rgfkycsdjdhfbchagkpg`cr*

Yk Orhgj `gckgj caaj sgpag~hck -I\C@#Ygaupdafpck urcagr caaj sgpag~hckhgr frfyj`f gj yk orhgj caaj sgpag~hckdhfrfk bchcjagkpg`cr* I\C@ |g yghgkpcl CoF gkyckhccjcj fsj fchg`g orhgbchagycawmpgagh drpfk ogjgpck pgaghhgrc dh`wwjf cfrgp gpagkpg`cr* Mgr sfpf orhgbchagkhgbcrhckpg gj yk 7!65 |g 25!95 sfhfrj`f drpfsf kp( grckcjhgr`g yk orhgj bcrcaaj sgpag~hck dh`ww bchcjagkpg`cr*Ygrwa CoO( CoF `~gshgrc `k CoA `gckgj`cr* Mcudofafohdbwhcjgacjcj pcu |g`grgigyc `gckgjhck oypgragkpg`cr* Mgpgrdngj bcr orwu mfypfhk dhwu lfrkh `glgkphgrhgdrpfsf kafkpf`r*

Pgkrfrhfsfj gjlgkycsdjhfr `j`f ofyprdcjpgypcjfh pwpwhwa( hgjldc` mcugrprdlc(dpdcaaj mfypfhkhfr( afhcojfjyc cjyc`fjyj`f frp( orfjwhdafpd~ hg~sdjhfrj |frhbfhif ~ghhckhgrcjc dhwpwrafkpf`r*

KFSJFKHFR>

Fomfadmfaaf`c F( Admfaaf`c N( Ufr|fjgm J( gp fh Urdorgyycdj dl Yghgipc|g CoF

@glcicgjis pd Idaadj \frcfbhg Caawjd`glcicgjis Cjp Frim Fhhgros Caawjdh

255=;60?>=?32Fpkcjydj FR( Rdclafj IA* Hd ygrwa caawjdohdbwhcj O2 hg|ghy cj cjlfjis ifj bg

prfjycgjp* Ug`cfprciy* 255?;625-9#>g709!?*

Bdjchhf LF( Bgrjypgcj CH( Kmfj @F gp fh* Urfipcig ufrfagpgr ldr pmg `cfojdycy fj`

afjfogagjp dl urcafrs caawjd`glcicgjis* Fjj Fhhgros Fypmaf Caawjdh* 2557;30-7

Ywuuh 6#>6! fj

wu`fpg lrda pmg Cjpgrjfpcdjfh Wjcdj dl Cawjdhdocifh Ydicgpcgy Urcafrs

Caawjd`glcicgjis @cygfygy Ihfyyclcifpcdj Idaacppgg*N Fhhgros Ihcj Caawjdh*

255?;625-0#>??

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Atkinson%20AR%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Roifman%20CM%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17952897&ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17952897&ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Roifman%20CM%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Atkinson%20AR%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus

8/9/2019 sk grlen immun yetmezlikler

5/5

Ypcgma GR*Pmg ldwr adyp idaadj ug`cfprci caawjd`glcicgjicgy* N Caawjdpd}cidh*

255=;7 -2#>22?!90*

Bfhhd B* Urcafrs caawjd`glcicgjis `cydr`gry> Fjpcbd`s `glcicgjis * N Fhhgros Ihcj

Caawjdh* 2552;653> 7=6!736

Agspy C( Bdyywsp ]( Urdgyafjy A( @g Bdgik* Cydhfpg` CoO9`glcicgjis cj imch`rgj> pd

prgfp dr jdp pd prgfp4 Ifyg urgygjpfpcdj fj` rg|cg dl pmg hcpgrfpwrg* Ug`cfpr Fhhgros

Caawjdh 255 6?> 700775*

Ucifr`( I( Uwgh F( Bwypfafjpg N(gp fh* Urcafrs caawjd`glcicgjicgy fyydicfpg` cpm

ujgwadidiifh cygfyg 2559;9- 076!073

http://www.ncbi.nlm.nih.gov/pubmed/18569394?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumhttp://www.sciencedirect.com/science/journal/00916749http://www.sciencedirect.com/science/journal/00916749http://www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%236840%232002%23998909995%23317220%23FLT%23&_cdi=6840&_pubType=J&view=c&_auth=y&_acct=C000038678&_version=1&_urlVersion=0&_userid=691275&md5=c310fceab19dbe5d9ff339453823d3ffhttp://www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%236840%232002%23998909995%23317220%23FLT%23&_cdi=6840&_pubType=J&view=c&_auth=y&_acct=C000038678&_version=1&_urlVersion=0&_userid=691275&md5=c310fceab19dbe5d9ff339453823d3ffhttp://www.sciencedirect.com/science/journal/00916749http://www.sciencedirect.com/science/journal/00916749http://www.ncbi.nlm.nih.gov/pubmed/18569394?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum