state of the biotechnology industry in japan biotechnology of japan mitsuru miyata, the excutive...

The Next Challenges

in Biotechnology of Japan

Mitsuru Miyata,

The excutive leader writer,

Nikkei Business Publications,Inc.

宮田満日経BP社

Global Forum on Biotechnology, OECD, Nov.12,2012

Outline

Current status of BT and Pharma in Japan

History :National Policy to promote BT

Top down Policy does not go well now.

The Next Challenges of BT in Japan

For Last minutes, critical problems in

Biotechnology in Japan

5.3 trillion yen ＊Instruments/Reagents(3.1)

＊Bioinformatics (2.2)

Tools/Informatics

8.4 trillion yen

＊Pharmaceuticals

＊Medical devices

Medical

6.3 trillion yen

＊Functional Foods (3.2)

＊Others (3.1)

4.2 trillion yen ＊Bio-process (3.6)

＊Biomass (0.2)

＊Bioremediation (0.4)

Environment/Energy

Foods

Total

25 trillion yen

Expected market in 2010 on “National BT Strategy ”

21 25 trillion yen = 220 bil. dollars

Real Bio Market in Japan

Over 2.4Tyen in 2010

( in M\ )

Pharma in Japan are failing down

Patent expiration of Major Product

Emerging Technology

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1150Byen in 2010,

Import surplus of Therapeutics

Emerging Technology Information

Center、All Right Reserved,

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Publications,Inc.2003

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Lost decade of Japanese

Biophartherapeutics

(山口ら、09年）

Reasons of the first failure

in Biotechnology in Japan

Conservative culture

Bad and Poor Science Policy

Gap between industry and Academy

Poor venture financing and activity

Poor Public Acceptance especially to GMO



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The New strategy for

national growth by DPJ

Dec.39,09 Av.3% GDP Growth until 2020

GDP 650 T Yen in 2020 (473T Yen,2009)

Unemployment rate less than 4%



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Goal :Job Creation for Brain workers

No one believes the policy in Japan

Energy/Environment Health/Medical/Care



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Research Institutes of Big Pharma.

Disappeared in Japan

But,

Big Pharma may loose

good opportunities of

Bio Innovation in Japan

New type of biotechnological research based on Japanese culture ----Full Length cDNA Project

not enough money and human resources for whole human

genome analysis in Japan From 1997, focusing research on full length cDNA due to less than 1% of genome

Now, We have about 30,000 cDNA Applying to Targeted Proteomics to find the function of genes and make them patentable.

Full Length cDNA Project leads to

Innovation of iPS Cell

Full Length cDNA Project leads to

Innovation of iPS Cell

20th Nov,2007 Human iPS Cell

2006, Murine iPS Cell Established

4Genes Introduced Oct3/4、Sox2、（c-

Myc）、Klf4 ,selected from cDNA Database

New type of biotechnological research based on

Japanese culture Personalized Medicine

Hap- map Program

Genomic Cohort study

From 2003,

the national program

collecting DNA and MR

from 300,000 patients

GWAS can find genes with high risk of diseases

Disease Risk gene

50万個のSNPが並んでる〔鎌谷、2008）

Poteligent CH Engneering

Eradication fucose from IgG

Poteligeo Launched

29 May in 2012 Kyow Kirin

antiCCR4 Mab with modified Sugar chains/

Adult T Cell Leukemia



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The only one commercial plant

for recombinant hAlbumin

Oct. 2007 operation

Pichia based Fermentation plant

New type of biotechnological research based on Japanese culture Bioelectronics/Nanobiology

Bio Computer



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Super Computer “KEI” began

operation in Sept. of 2012

Molecular Dynamics

Protein/Ligand Simulation with KEI

Virtual Drug Discovery

3.5PFLOPSの京コンピュータ上で、1.315PFLOPSの性能を達成効率 37%

細胞混雑下でのタンパク質動態シミュレーション

1.8億原子、カットオフ

これまで行われたタンパ

ク質の分子動力学シミュ

レーションで最高の性能

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※本成果は、グランドチャレンジプロジェクト「次世代生命体統合シミュレーション」の一環であり、早期の成果創出の要求に基づきマシン割り当てに特別な配慮をいただいて実現したものです。

New type of biotechnological research based on Japanese culture

----Functional Food

Food for enhancing health , based on research of traditional dishes in Japan

Our longevity is partly due to Japanese food

More than 2000M$ for functional food market Modern Biotechnology is applied to study and to understand healthy element in food at molecular level

March 11th ,2011

East Japan Earthquake and Tsunami



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Big Money to RecoverTohoku area

Some in Advanced Medicine

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Tohoku Medical Megabank

15.8Byen（2011）＋5.6Bye（2012）

3Generation Genome Cohort、150,000people

Multi Omics Research Center

Fukushima Drug Discovery Platform

25.8Bye for 10years from 2012


Fukushima Pref. Med. Examination 2Mpeople

We need risk money

for emerging companies

Source: OECD 1999-2004, IVC

Research Center 2004



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Failure to Get Public Acceptance

to GMO in last 2decades

Almost everyone believe no GMO in Japan

The largest importer of GMO on the globe is

Japan

Japanese travelers love to eat rPapaya

in Hawaii

nether in Japan

Future of Japanese Bioindustry

Hoping Bright Future

By Continuous Scientific Innovation

By Fusing BT,ICT, NT and ET

By Combining Innovation , Precise

Manufacturing and Design

By Creating and Financing Smart Bioventure

Companies

BY Alliance with Global Talent and Brain

The Last Critical Question:

Can we pay for Next Biotechnological

Inovation?

10.0% of GDP for Healthcare

1000TYen National Debt

The fastest aging society on the globe.

The Final Option →VAT or DEAD/Debt Austria ２０．０１%

France ２０．６１%

Italy ２０．０１ %

Germany １６．０１%

England １７．５%

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Contact::

[email protected]

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