sterili(bpd)

8/6/2019 sterili(bpd)

1/10

Storlllzsonofblorcsctorstodlz6on s hl pl@E. ct 6nd.ini |net dab c e condt i \^itchh tot6[,r,svotd ttlvtng ldooqanl3ms.t 16 nabsotdr ondi . a^d, nprrcric,ltb on dorlrltch s.pprcrchedn temso! achiovin!n a@eprebt6robablliryt thdab3.n6o, vtabteoEenisms.n n6 onbn tbior6acrJresign,roritizauonas heeapplicslions:

\"1'"di

Pr6sre.iliationlqlipn.nrslvaintenanet stedte pe.aungondtuons

h rhy, lhb mrns hathaving mued rh6latl.e6ssary ro prevent nlly or Mrnja0 infedtnspeiod rplaniopeEtion. ! i-'eaD|e lganbms r .bsent isnicoorgan'smsdudng he onti.e

Sieiliz.lion en be adievsd by:


2/10

Itdairy,blolochnologyndphtm.cou cal indusldosolhor b6n6lit3ol a *l! d3sl9n6dCtP plgnl Inchd6s:opodtot s.l6ty (op66lou 6|0 nol Gqullld L 'nt" lenls andvoBsotso cl.!n ft6m and potsntcLlni.g mr|6d.h do not n6d lo bo h.ndlod bvoDto!s),and do\4.lin6 (f .nv) b.teen producl runs / trcduct chdng.owr ls

rhe rechnologyl CIP Cleaninsrn-Pla@)ndSIP sleili:alon_rn_Place)s obviolslvimporrad to many indusl.ies including food dairv beveEge nutdedilbiotechnolosyhamaediel cosmellc e'llh andpeGonal re indusl'iesnwhlchthepocessing ustake lacena hygie^icraseplic ftnonmenl

Cleaninq.ln_PlaceClPlctP tcloanln+lac6)k a melhod f cleaninghe nle,jor6uda@s l pipesvessels'p@5s equipmentnda$ciatedfiings wilhout isassemblvp to the 1950s'dosedsystems re disassembledndcleanedmanuallv-headvenlol clP Ms aboono indusfi;s hatneodedcquenl ntm.lcleaninq fbeir prolEsses ine the1e5os,CIPha;;iwd lt' includsulli auionated FtemswiltrprogmMblo loqic@ntolle6,rnulip6bltln; bnks.seNo.s,valvesneaterchangers ataacquisilionandspe.i.l9 des-Eoedpirytozle syslemsslmplemanuallypeBt\td lP 6vslnsn 6!rrbe oLiidh G;6irlt ' " '. , . r , : r i i , . . ! - . IclP standsor'cbailt|g in Pli.' ands widelv sedn all s orpro'essnd6tries'r ha3b6ndeEloped.rMii-Equ:Em6orhatpo$ lrdctrvtalllg T u:detroentb o gainmdimum@d beoftsclP @!Bs Etie9 olerrpos h to imov lolids.id bededa6m Esse\ andPlpem* ln &e fooderddd"k@3fls"r,{.ff.j;iir"",..'.,'.,, . . ! i,

' :Th askof AbmtntlindiD@ssanl orclea'ings Lne consLmingndwherea1|.eniryE @qulted,t bemB dangercus lt wee feaslble l all ClP allo6 pr@ss denland rDewotko b cleaned tween .oss runswilhout herequlemerl o dismantleor enter ie quiphont t @n be6nied olt with Lromaled r nanlal syslens5nd s arriable nd eptable pocss hat meels he.l ngenlhygiene egulationspecialvprevalenln he ood,ddnkandphamaeutlEl IndGtn6.


3/10

Thonalonry t cl6anin9nd 3rorlti:ingiqutdsoednctp sysremsr6atrati r crdba66dnd h6clP svdemw t altow ccurstoo6in9, hs conconkdtodt6rntnogont,nonna hto wat.r ogrt6a tos.tBngth otuuor.ubto orcbEntngroc5sDtanlThis otutions h6n sed htn hoptanloctasnnd , nsqssary.nl'e ihesyslemonorb lhene{ oroduclionun

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BenetilsofCleanlnon Plac6lclplCloa.lDo . Placehashrny bengits o h6 endihplementi.gCleanlrOh Pl&o ,|el

user.soineoflrE hain Easons or- Salety peratoB fenorequied to e.rerplenro iean r- Dffclll lo ecessa.eas n b. ct66ned- PEduclionoln lihe bed,n Fdud unss mr,tnised- Cleaninglstscanbe rduceduGtanltatiyy Erycting reanng- Water onslnplions Educed s clearing rctes redlsqned o-fte deening ystemln be utyulcma.bdholEf@educhgEbour quiernenls- AulornaledIP y6tem!angtwEuq.shtedndFnled 6nd 6peEbbt6 uahysssu.sne- A,rldnatedtp EFrerslan FoJide r:itraia oqginsorquarnyssuane-

:@::us l4irn:m.rMd. & nornodobehsndrodyope..roE

- Uso r cleantng teEts is horoefiocnty onrotredeing Ctp3ysren


4/10

IIIltIiiII

ln s te i!-.ul.tionvs|onr ho 'loenln{lint6dLrcodo thoplanlobs closned lsolutlDns nraderp n an oxlsmal ankthonb rcclrculalednd oPp6d p as lEquldunlil

rhe lsanhg ycl. compleloWhenhedele'oenllean6@mdel6ll s h6nnolrnelio

tnoen4l Ec.rculaironvsbn!Jse esswaler clean'ngetelsisbulEquGgralercapUr u ayana,n"ote crromsta'@s avbeunsuil'btdue o do$ @nlsmin'onfton one Prcess lo anothor'we @n ll requied @idjate 6as for th66 tvpes@frparcd o .n xislingsvstem o demonsrat6polenli'l @3t savinssand pavback

SvstenDesldn. t*,* a*'t" -*ri"ram ro, a Cl'lnlns In Pbcoststen s'lh6r"danln!EqulEme' d ch pDcs* vossr'F.cloB o b@nsldsedal l"il'fr*:E" :rthe odtsB ves.lsi .!and;d or cl6eningoquled lhqavsllable leanrnglrn6 ne vp

'd detesnt c '6-6 'us6dol cleanlns medium .nd wnotlEr rsclo!- --" "- : *,1"vMlh his Inronna{oneanr'shesdscanDe 6roc1ed" ''l ih6:'fsilirim;d"descdbedsbN Thi. then do$ pumps o DeseEc{ed o m'tc$ lhe fioii;n& &uld

lor the head5and lhe type ol ceaningnalenal oe'ngLseo The moduloEe

'nd@nfiguEfon c5n also be el@ aled lrcm th! 'iiromalan, '. ' , , i | : ,1 , , .'"rl iel:''r' '

' l r in ' !


5/10

An erampleof a throo.tenkClernlno n placesvgtemThsr6arothreoholding anks,whicha mounbd n d 6taintos! toot band,Tho snksala nonnslly bulk@ustic aok,dillr6 doreqont sn| and ish volof ank.Thoopadtyof 6aolr ank s slculslod cco.dingo tho nlriat ystem oqutcmonrs 6sc bodabovet. lho casol the burkdeanlno huidrank h6cuftomermayatso6p.city ho anrr izato 6uttoprimun eliveryuanrities.u|kcbanlngiquid s nomIy dlivEdo aconnecfion oint oubide the p@ss ptantand puinped o rh6 sror.ge tank by ihedefverywhicr.Heating n be Epecitiedo. the but| ctsa.ing iquidahkdependjng nilr. p.ope.liesor the clean'ngagenr lagging and ctaddingcn atso be ,itrdtorlmprord neroy mcie.cy-

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The bnlkcleaningiquidaspumpd rhedereqe.lalon! with water o maksup3 batctof dele|lent,ofoclivat a higheremperatue.I lhi. is rhecase tplrr6 he.r ;xchengs io bd t totank beloreach cteaning yctThe deterggnts nom.lty more

murd rhe. be pumpedhough aIne reqlird temperatlro.

, ..,,1:l!ii'.en$htihecteaningeteqenrsnoftnalyGrared" porc"nr"q"trhe!"anlnsi" '1, .. lgentb6hgusedusuauyilhgarer). thenajor8 orcas6 $rs sbetw.n , and, . 1,0% y.vorume.hs are vaddusmelhodsot achieving h. requiEdsir.ngth buttho . . ,,, rr S{.Dah. r,Eqodsae a)udry a posinedrsctraEeump hm rnrheaias;; br a .) ".,toalc'Iaidm andb) usiig a condudivty rcbao Ead rhe rrensflioi rh6daersc,jt, ,_ . *., I (!hi6r onlyeffedivewih alkatis, oracids).The6nducrjvi9p6be iE ored rnm.; . --;, recidlalion/scsEnge.ine,

TheglriemshoM allo$ tnedere|gedo bo lsddtai.d lhirjgh th. hearordEngerudll lt rBach* heoptimumemp.fatue.Thehetexchdgerhbutdbc dsiqnedo suir.th empeEtule op l. a r6ciutalion6y!tem.

. $/henIhe dete.gen!s eady tor B! the pbces w*el ro b cteaned s seteridand . ., rne Gysrehwill run hrcuqha cleanlnootrte. A prB jn6. w t b6clnied out tiEt uslng ...srl6. frcn he nnsewater ank.ThedeteEentwil lhen b cyded hrouoh he oess6yBlm erobeingetumd o lho dereEontank A tina,dBe w'[ lhen beca4iedoutagain dngwler honthedn* walerank.


6/10

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Oolondif,gn.uslomor qelcdonl3 hl! d6tOonl.n thonb.6_o!od b{lkcloanirr!thuld b.lns adloda3 no@ssarvo malnloinheroquiEdcl.aninsd.onclh bvw! or hopFvtoudymbdlonod ondudivitv obo ll mry b. ufldosnabb sohd 63$ lo @s0do!6rlont nsnothrPanol $e proesl 6ttl6m due o crosr contamln.llon l lhl! wo.orh6 c.se tho debrge.l u/ouldb6 dumpod o d.ain alid !s6 ll n F not prsclical odirchd!6 lho dsts'!nl to d6in 6G n alksli/acldhsn m dn m3lalra 5v{0m to

theclP systems beingsed to cle8n .umberot ves$ls the. o !'feglard lheve$els/planlnol beingclanedt iB ncessaryo havea safe valveor sidil'r svslemThedouble e.i (bod andbleed)v.lves 6hownh'e a chaftberbelween lvov'lvDseats. ,!hen heval is open huid w now hrough ryhenl is cl6ed the chamb"betw6onhe !t{o Ne seatshas an oPnpan so ihel anv cleaningiquldpassingthoulh lhe nlel66iwi[ ddln out ol thechember nd c.mt eu6o contaminatio. llh6oulletsideol hslveAnolhrnerhodof ensunnghat thetb s no @nlamin.tion f olherpioess li.es dldngoleenings to ose a seing bend l platesy.tmwtre d dired connodlons nadftrln tls CIP &ed.lo lh pipeline eding the pocess plant o b clned, Prolimitv!r,ltcaEsnay be usedwftn h slvingbend o eNu thar he cofiectpatnb 6electedbefoe vel!sc.n botlend ndcle.ningdaded

. . . . , . {F.oces3Control "i*' .iYThe6nt@l orct ;dn! ini lci iFreos en varv rcn eimpbmanuel pEuonorvrrynracaeorb.orrif!ftuiluct "*n ope.aro,t",r"ces hodosisnr heco.ltrclsvste'n ii v#';ffir;; b ul pocessbeinscleaned ndrhe@!lome6@uments. 't i h

.ve$et Cteanil_qj. rr ..theE aB a rietv ol difeen(.PEv dvi6sdependantn . vadet ol taclo6 hdudingc'Pilalchaning ime,ss6l5i2e. Ptavvpandsoil ype


7/10

Fl{d soriv a.ll!Fl,dpraybalb16 lowcosr,owmarnronsncd.bul us. l 9hvolum$olwalor.Ctoanhg nesE3 mal@s. hesetemshava tixedspreyprirelnw3!l is badly oil6d rhasmatedetakod n.

Theyoporato t otuprEsurd2b.r)long8nd a,Eo6ndso b,bout2"anoaE notr6a[ysuir8blo henhc

v-,$' ,\ ;

' rL: i . i i . . , . , r , . ,ii,ii";n riiiirni'n.iad- r-.-erv.s".raTnes erd3 6 highgssue unik,hth [email protected] deariaq he3nEn6r ep|tar,@sl36 invotvedburtuIy Indexed oveEE; d bng ra.ge usnq towvorums ol Eter 6nddelergonr itl compeB.tefor hi.

. :.i i,]r.,.,-...-l'tff.frtq,1 .t.{il-"'


8/10

SonvPalterngsomoot tho common3pEt patl6m3 vall.bl6.indlvidualBqul.6m6nts nd n lhe caseol Laq.of rheve6sel an bo rvoidod rnocs$a.y

i:,i - r| .ut Il'1."s-i

Sterilizationn PlaceSlP)lntroductionWrn pbe6s equipmeit Eacl'e! comneroiaLkle pllpotion!, lhe sterilEalionotessentialni6 by .ltodavinE beomes lmpEdicaland 6omemoansol slrilizhg rreequlpmenln .n! is n6ded.Sudl Installelom, n oder to coftply $dlh GMP, musl edEslgn,nsiarr.tion,nd opeEliohallyqualilid oa. lo, andoq and h GtedlEatonproco$ m6t bvaridald.o, hee is a 6hon nttDducliono th 6redliz.tlon In Pl.ce(slP) addauonEceduB. : . - . : r .

, i : r . i ) ini ,* ,r , .Oetailsof Sterillrrtion In Place slPla {ili r, . , I , i , ,rA stedrt ruon In Pl.coiP) {ndallEtlonil u;ualv.omPd!. oneor moreplMssng equipment.uar ar a roinenroiirio d 6inrlil,sat sep"cto'hadesG,@n@cted y dqidstaint*s slealorflenbleTeton@lined iphg'

: I i i IThe ndrhtion wll be capableof $lthstandino teampBsure up 1o,sav 20 psi6'[email protected] he l2l' to 125'c Enge Thee sill bea 5uPplv' 'ot steao suhabled ihe prce


9/10

*IFtt!IIl!IItIIIIliIt!tt"IN.iIII

Docltnqlrtificsllonot a stp instaltalon il equ]E contimrton tE! !h. procescqulpm6nl, lp6md(, and 3toamupptyoqllpm6ntm..t ploiot 6fclfica(oruormare6ls6nd orprAsuroand emporrluequalily l ho5team,vtrich tt boLrsed. hisin s dodicatodcl6a;-sto.m" eneratorhe

,6isrance. ton on mu{ b6patdo tiouslaflyman6tat tho3l6am gor6rat6dsreammayabopassa mtdljtt.r beroe

hstattrtimqlafirrcaliont a @tkesignedSlpsysteheilt involveodi;hg lh6prope,insretbtiont hepro.oss quiprnenrld @ftect iriilsand@nncrionsora[ pipo yD.k,inclLdingnsudngnatplqpr.ondensa!6dEinage anocd/i Thestritirng ydo s .then ur Sblm under Bssu.e p6sd hrcuOhheenur srr0atio{j/hflolowind

o&e. d4ign sspecrsof the equipme,t nlendedor stp wil inctdo e.su,ins that ]llestean en each a padsot the equiphdnt n conlactwithproductand hat ah is noltppd n rheplartdudng6tditt rion.Finaly, empratuFensorsmuslbesit\edfere theywil r6pr6ent etiabtyheslateotih6oquipmodunr/gheste.itiatoncyde.

rheescapodair hroughropdy,acednA n hepiplng .onn eqrhftentThse@ s 8re6!a[y prcte.ld.by taam4sistantb.clenlt tittes.


10/10

' i t ' j|lt ot atr,and nar h6 coldnsalodt''n T16 oE66tFd rioll{6llo^ cYcl hoJh'

'' I atMvt vlcld!t'tl'6 Indl0'lo6ithtmum md frs{mufi thils on the slam pEssum. hdicatod smp6slu|d' tnd' oxpoours me wlll b s6l ll sppropdale ho linal svldenoeol tht v'liditv ol th8.bdE Uon |ocati maybe acnbv6dbt runnlng@lturEm6diun hough th' 3ledlized!d up n mitation f thmsnulaclongpocess66and hon ncuballno la|! nuhbe orm.1i6smpld3, t thoe.ti6 balch to ensoE no bactodal mw{h@uG

h any e!.1, ihe regularmanlfaclue ot p.oductbalches wr"ch passe.dobnn |eds anr poesslng in the stP pltnt nill @nli'm Po or

sterili(bpd)

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